IL106860A - בידור, איפיון ורצף חלבוני של רספטור הורמוני המשחרר את הורמון הגדילה ושכפול הגן המקודד עבור רספטור הורמוני המשחרר את הורמון הגדילה - Google Patents

בידור, איפיון ורצף חלבוני של רספטור הורמוני המשחרר את הורמון הגדילה ושכפול הגן המקודד עבור רספטור הורמוני המשחרר את הורמון הגדילה

Info

Publication number
IL106860A
IL106860A IL10686093A IL10686093A IL106860A IL 106860 A IL106860 A IL 106860A IL 10686093 A IL10686093 A IL 10686093A IL 10686093 A IL10686093 A IL 10686093A IL 106860 A IL106860 A IL 106860A
Authority
IL
Israel
Prior art keywords
receptor
ghrh
growth hormone
releasing hormone
nucleic acid
Prior art date
Application number
IL10686093A
Other languages
English (en)
Other versions
IL106860A0 (en
Original Assignee
Thorner Michael O
Gaylinn Bruce David
Zysk John Ronald
Lynch Kevin
Harrison Jeffrey Keith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/946,232 external-priority patent/US5591641A/en
Priority claimed from US07/947,672 external-priority patent/US5612470A/en
Priority claimed from IL10611293A external-priority patent/IL106112A/he
Application filed by Thorner Michael O, Gaylinn Bruce David, Zysk John Ronald, Lynch Kevin, Harrison Jeffrey Keith filed Critical Thorner Michael O
Publication of IL106860A0 publication Critical patent/IL106860A0/xx
Publication of IL106860A publication Critical patent/IL106860A/he

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
IL10686093A 1992-09-15 1993-08-31 בידור, איפיון ורצף חלבוני של רספטור הורמוני המשחרר את הורמון הגדילה ושכפול הגן המקודד עבור רספטור הורמוני המשחרר את הורמון הגדילה IL106860A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/946,232 US5591641A (en) 1992-06-23 1992-09-15 Nucleic acid encoding the growth hormone releasing hormone receptor
US07/947,672 US5612470A (en) 1992-06-23 1992-09-18 Nucleic acid encoding the growth hormone releasing hormone receptor
IL10611293A IL106112A (he) 1992-06-23 1993-06-23 בידוד ואפיון של רספטור הורמוני המשחרר את הורמון הגדילה

Publications (2)

Publication Number Publication Date
IL106860A0 IL106860A0 (en) 1993-12-08
IL106860A true IL106860A (he) 1999-08-17

Family

ID=27130233

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10686093A IL106860A (he) 1992-09-15 1993-08-31 בידור, איפיון ורצף חלבוני של רספטור הורמוני המשחרר את הורמון הגדילה ושכפול הגן המקודד עבור רספטור הורמוני המשחרר את הורמון הגדילה

Country Status (12)

Country Link
EP (1) EP0591697B8 (he)
JP (1) JP3393159B2 (he)
KR (1) KR100342153B1 (he)
AT (1) ATE202141T1 (he)
AU (1) AU673188B2 (he)
DE (1) DE69330329T2 (he)
DK (1) DK0591697T3 (he)
ES (1) ES2159512T3 (he)
GR (1) GR3036486T3 (he)
IL (1) IL106860A (he)
NZ (2) NZ248602A (he)
PT (1) PT591697E (he)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2634926B2 (ja) * 1990-04-19 1997-07-30 シャープ株式会社 かな漢字変換装置
US5852187A (en) * 1992-06-23 1998-12-22 The University Of Virginia Patent Foundation Molecular cloning of the ovine pituitary growth hormone releasing hormone receptor
US5973114A (en) * 1992-06-23 1999-10-26 The University Of Virginia Patent Foundation Isolation and characterization of the growth hormone releasing hormone receptor
AU2003238032A1 (en) * 2002-06-24 2004-01-06 Bayer Healthcare Ag Regulation of human growth hormone-releasing hormone receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2085362A1 (en) * 1990-06-29 1991-12-30 Arthur M. Felix Histidine substituted growth hormone releasing factor analogs
US5288621A (en) * 1990-12-14 1994-02-22 Cornell Research Foundation, Inc. Pituitary TRH receptor
US5225543A (en) * 1991-03-28 1993-07-06 American Cyanamid Company Receptors method for purification of g protein-linked
US5973114A (en) * 1992-06-23 1999-10-26 The University Of Virginia Patent Foundation Isolation and characterization of the growth hormone releasing hormone receptor
WO1994007915A1 (en) * 1992-09-28 1994-04-14 Northwestern University New growth hormone releasing hormone receptor protein

Also Published As

Publication number Publication date
AU4734093A (en) 1994-03-24
JP3393159B2 (ja) 2003-04-07
GR3036486T3 (en) 2001-11-30
EP0591697B8 (en) 2001-11-14
DK0591697T3 (da) 2001-08-27
KR100342153B1 (ko) 2002-11-22
EP0591697B1 (en) 2001-06-13
EP0591697A2 (en) 1994-04-13
IL106860A0 (en) 1993-12-08
DE69330329D1 (de) 2001-07-19
DE69330329T2 (de) 2002-01-03
ES2159512T3 (es) 2001-10-16
KR940007181A (ko) 1994-04-26
ATE202141T1 (de) 2001-06-15
PT591697E (pt) 2001-11-30
NZ248602A (en) 1996-06-25
AU673188B2 (en) 1996-10-31
EP0591697A3 (en) 1994-11-23
NZ272688A (en) 1997-07-27
JPH0769916A (ja) 1995-03-14

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