IL97994A - Their preparation inhibitors and pharmaceutical preparations containing them - Google Patents

Their preparation inhibitors and pharmaceutical preparations containing them

Info

Publication number
IL97994A
IL97994A IL9799491A IL9799491A IL97994A IL 97994 A IL97994 A IL 97994A IL 9799491 A IL9799491 A IL 9799491A IL 9799491 A IL9799491 A IL 9799491A IL 97994 A IL97994 A IL 97994A
Authority
IL
Israel
Prior art keywords
amino
dihydroxy
ylsulfonyl
cyclohexyl
methyl
Prior art date
Application number
IL9799491A
Other languages
English (en)
Hebrew (he)
Other versions
IL97994A0 (en
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL97994A0 publication Critical patent/IL97994A0/xx
Publication of IL97994A publication Critical patent/IL97994A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL9799491A 1990-05-11 1991-04-29 Their preparation inhibitors and pharmaceutical preparations containing them IL97994A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52234990A 1990-05-11 1990-05-11
US56492590A 1990-08-09 1990-08-09
US68366391A 1991-04-15 1991-04-15

Publications (2)

Publication Number Publication Date
IL97994A0 IL97994A0 (en) 1992-06-21
IL97994A true IL97994A (en) 1996-10-16

Family

ID=27414825

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9799491A IL97994A (en) 1990-05-11 1991-04-29 Their preparation inhibitors and pharmaceutical preparations containing them

Country Status (14)

Country Link
US (2) US5310740A (ja)
EP (1) EP0456185B1 (ja)
JP (2) JPH07607B2 (ja)
AT (1) ATE123282T1 (ja)
AU (1) AU646859B2 (ja)
CA (1) CA2041825A1 (ja)
DE (1) DE69110086T2 (ja)
DK (1) DK0456185T3 (ja)
ES (1) ES2075261T3 (ja)
GR (1) GR3017168T3 (ja)
IE (1) IE68045B1 (ja)
IL (1) IL97994A (ja)
MX (1) MX9202877A (ja)
PT (1) PT97631B (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors
US5523289A (en) * 1991-04-15 1996-06-04 Abbott Laboratories Pharmaceutical composition
DE4215874A1 (de) * 1992-05-14 1993-11-18 Bayer Ag Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5298505A (en) * 1992-08-14 1994-03-29 G. D. Searle & Co. Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5252591A (en) 1992-08-14 1993-10-12 G. D. Searle & Company Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5605919A (en) * 1993-02-26 1997-02-25 Takeda Chemical Industries, Ltd. Treatment for viral diseases
IL108924A0 (en) * 1993-03-19 1994-06-24 Ciba Vision Ag Compositions for the treatment of eye diseases
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
US5705524A (en) * 1994-11-04 1998-01-06 Gilead Sciences, Inc. Thiepane compounds
US6034118A (en) * 1994-11-04 2000-03-07 Gilead Sciences, Inc. Thiepane compounds
TR199901765T2 (xx) * 1997-01-23 1999-10-21 F.Hoffmann-La Roche Ag S�lfomid-metalloproteaz inhibit�rleri
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
EP1517682B1 (en) * 2002-06-28 2006-11-02 Speedel Pharma AG Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant
US7819192B2 (en) * 2006-02-10 2010-10-26 Halliburton Energy Services, Inc. Consolidating agent emulsions and associated methods
EP2163245A1 (en) * 2008-09-10 2010-03-17 Novartis Ag Renin inhibitors for the treatment of psoriasis
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812442A (en) * 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
US4906613A (en) * 1985-11-05 1990-03-06 Schering Corporation Antiglaucoma compositions and methods
EP0309766B1 (en) * 1987-09-29 1998-04-15 Banyu Pharmaceutical Co., Ltd. N-acylamino acid derivatives and their use
US4927807A (en) * 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
CA1328333C (en) * 1988-03-04 1994-04-05 Quirico Branca Amino acid derivatives
US5036053A (en) * 1988-05-27 1991-07-30 Warner-Lambert Company Diol-containing renin inhibitors
WO1990005531A1 (en) * 1988-11-21 1990-05-31 Abbott Laboratories Method for treating vascular diseases
DE3839559A1 (de) * 1988-11-24 1990-05-31 Hoechst Ag Renin-hemmende aminodiol-derivate
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
DK0410278T3 (da) * 1989-07-25 1994-05-24 Hoechst Ag Reninhæmmende aminooligohydroxyderivater
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
CA2023099A1 (en) * 1989-09-04 1991-03-05 Quirico Branca Amino acid derivatives
NZ235234A (en) * 1989-09-12 1992-12-23 Hoechst Ag Renin-inhibiting amino acid derivatives and pharmaceutical compositions thereof
US5122514A (en) * 1990-04-23 1992-06-16 Abbott Laboratories Psoriasis treatment
US5089616A (en) * 1991-04-23 1992-02-18 Warner-Lambert Company Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide

Also Published As

Publication number Publication date
JPH05271194A (ja) 1993-10-19
EP0456185B1 (en) 1995-05-31
IL97994A0 (en) 1992-06-21
EP0456185A2 (en) 1991-11-13
DE69110086T2 (de) 1995-12-14
US5310740A (en) 1994-05-10
AU646859B2 (en) 1994-03-10
DK0456185T3 (da) 1995-10-30
JPH07607B2 (ja) 1995-01-11
IE911404A1 (en) 1991-11-20
EP0456185A3 (en) 1992-10-14
MX9202877A (es) 1992-06-30
ES2075261T3 (es) 1995-10-01
PT97631A (pt) 1992-03-31
PT97631B (pt) 1998-08-31
GR3017168T3 (en) 1995-11-30
AU7607791A (en) 1991-11-14
ATE123282T1 (de) 1995-06-15
IE68045B1 (en) 1996-05-15
US5284849A (en) 1994-02-08
DE69110086D1 (de) 1995-07-06
CA2041825A1 (en) 1991-11-12
JPH04279572A (ja) 1992-10-05

Similar Documents

Publication Publication Date Title
AU646859B2 (en) 4-(Piperazinyl, morpholinyl, or thiomorpholinyl) sulphonyl derivatives used as renin inhibitors, compositions and processes for their production
AU630386B2 (en) Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof
US5063208A (en) Peptidyl aminodiol renin inhibitors
AU759492B2 (en) Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
AU639212B2 (en) Non-peptide renin inhibitors
US4749687A (en) Renin inhibitors containing statine or derivatives thereof
AU613956B2 (en) Peptidylheterocycles
PL161527B1 (en) Method of obtaining cycloalkyl substituted derivatives of glutaramide
US5164388A (en) Heterocyclic peptide renin inhibitors
IE904404A1 (en) Pharmaceuticals
SK284915B6 (sk) Trombínové inhibítory a ich použitie
EP0840614A1 (en) Calpain inhibitors for the treatment of neurodegenerative diseases
US4857507A (en) Angiotensinogen analogs
JPH05213873A (ja) 経口活性レニン阻害剤
US4839357A (en) Renin inhibitors containing phenylalanyl-histidine replacements
US5332742A (en) Renin inhibitors
AU616071B2 (en) Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof
US5453488A (en) Amino-substituted heterocycles as renin inhibitors
US5258362A (en) Renin inhibiting compounds
US5219851A (en) Tetrahydroisoquinoline-type renin inhibiting peptides
EP0416393A1 (en) Peptidyl difluorodiol renin inhibitors
HUT52785A (en) Process for producing 1,2-hydroxy-phosphonates and derivatives
HU196833B (en) Process for producing peptide derivatives comprising statine or its derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void
MM9K Patent not in force due to non-payment of renewal fees