IL97481A0 - C-linked pyrazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
C-linked pyrazole derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL97481A0 IL97481A0 IL97481A IL9748191A IL97481A0 IL 97481 A0 IL97481 A0 IL 97481A0 IL 97481 A IL97481 A IL 97481A IL 9748191 A IL9748191 A IL 9748191A IL 97481 A0 IL97481 A0 IL 97481A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- pyrazole derivatives
- linked pyrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/175—Saturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909005354A GB9005354D0 (en) | 1990-03-09 | 1990-03-09 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
IL97481A0 true IL97481A0 (en) | 1992-06-21 |
Family
ID=10672340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL97481A IL97481A0 (en) | 1990-03-09 | 1991-03-08 | C-linked pyrazole derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (15)
Country | Link |
---|---|
US (1) | US5389659A (fr) |
EP (1) | EP0446062A1 (fr) |
JP (1) | JPH0625175A (fr) |
KR (1) | KR920005717A (fr) |
AU (1) | AU636720B2 (fr) |
CA (1) | CA2037872A1 (fr) |
FI (1) | FI911161A (fr) |
GB (1) | GB9005354D0 (fr) |
IE (1) | IE910783A1 (fr) |
IL (1) | IL97481A0 (fr) |
NO (1) | NO910935L (fr) |
NZ (2) | NZ237366A (fr) |
PT (1) | PT96976A (fr) |
TW (1) | TW211004B (fr) |
ZA (1) | ZA911721B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2659655B1 (fr) * | 1990-03-19 | 1992-07-24 | Union Pharma Scient Appl | Nouveaux derives d'oxypyrazole antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
CA2079343A1 (fr) * | 1990-03-30 | 1991-10-01 | Eric E. Allen | Pyrazoles, isoxazoles et isothiazoles substituees |
GB9110623D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
AP254A (en) * | 1991-09-05 | 1993-05-05 | Glaxo Group Ltd | C-Linked pyrazole derivatives. |
WO1993005025A1 (fr) * | 1991-09-06 | 1993-03-18 | Glaxo Group Limited | Derives de pyrazole lies a c |
GB2263638A (en) * | 1992-01-28 | 1993-08-04 | Merck & Co Inc | Substituted pyrazoles, isoxazoles and isothiazoles as neurotensin antagonists |
US5312958A (en) * | 1992-01-31 | 1994-05-17 | Takeda Chemical Industries, Ltd. | Process for producing 4-bromomethylbiphenyl compounds |
EP0577025A3 (fr) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Antagonistes du récepteur d'angiotensine-II pour le traitement et la prophylaxie des maladies coronaires du coeur |
DE69330593T2 (de) * | 1992-12-22 | 2002-06-27 | Takeda Chemical Industries, Ltd. | Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung |
JPH072859A (ja) * | 1993-01-28 | 1995-01-06 | Upjohn Co:The | ピラゾール誘導体およびこれを有効成分とする医薬組成物 |
US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
ES2105939B1 (es) * | 1994-08-02 | 1998-07-01 | Uriach & Cia Sa J | Nuevos pirazoles con actividad antagonista de la angiotensina ii. |
TW418204B (en) * | 1997-03-28 | 2001-01-11 | Dev Center Biotechnology | Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
GB0402262D0 (en) * | 2004-02-02 | 2004-03-10 | Novartis Ag | Process for the manufacture of organic compounds |
US7411082B2 (en) | 2004-03-29 | 2008-08-12 | Cambridge University Technical Services Ltd. | Synthesizing method for compound, and catalyst for synthesis reaction |
WO2005105719A1 (fr) | 2004-04-28 | 2005-11-10 | Cambridge University Technical Services Limited | Procédé pour synthetiser un compose et un catalyseur pour la réaction de synthèse |
US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CA3089569C (fr) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2930674A1 (fr) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP6275689B2 (ja) * | 2013-03-04 | 2018-02-07 | 国立大学法人 東京大学 | 蛍光プローブ |
EP2968439A2 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
-
1990
- 1990-03-09 GB GB909005354A patent/GB9005354D0/en active Pending
-
1991
- 1991-03-08 IE IE078391A patent/IE910783A1/en unknown
- 1991-03-08 EP EP91301933A patent/EP0446062A1/fr not_active Withdrawn
- 1991-03-08 NZ NZ237366A patent/NZ237366A/en unknown
- 1991-03-08 ZA ZA911721A patent/ZA911721B/xx unknown
- 1991-03-08 FI FI911161A patent/FI911161A/fi not_active Application Discontinuation
- 1991-03-08 IL IL97481A patent/IL97481A0/xx unknown
- 1991-03-08 JP JP3069159A patent/JPH0625175A/ja active Pending
- 1991-03-08 US US07/666,746 patent/US5389659A/en not_active Expired - Fee Related
- 1991-03-08 NO NO91910935A patent/NO910935L/no unknown
- 1991-03-08 NZ NZ244221A patent/NZ244221A/en unknown
- 1991-03-08 KR KR1019910003745A patent/KR920005717A/ko not_active Application Discontinuation
- 1991-03-08 PT PT96976A patent/PT96976A/pt not_active Application Discontinuation
- 1991-03-08 CA CA002037872A patent/CA2037872A1/fr not_active Abandoned
- 1991-03-08 AU AU72736/91A patent/AU636720B2/en not_active Ceased
- 1991-03-12 TW TW080101944A patent/TW211004B/zh active
Also Published As
Publication number | Publication date |
---|---|
NO910935L (no) | 1991-09-10 |
PT96976A (pt) | 1991-10-31 |
FI911161A0 (fi) | 1991-03-08 |
IE910783A1 (en) | 1991-09-11 |
AU7273691A (en) | 1991-09-12 |
FI911161A (fi) | 1991-09-10 |
NZ244221A (en) | 1992-11-25 |
CA2037872A1 (fr) | 1991-09-10 |
US5389659A (en) | 1995-02-14 |
NO910935D0 (no) | 1991-03-08 |
EP0446062A1 (fr) | 1991-09-11 |
AU636720B2 (en) | 1993-05-06 |
GB9005354D0 (en) | 1990-05-02 |
JPH0625175A (ja) | 1994-02-01 |
KR920005717A (ko) | 1992-04-03 |
NZ237366A (en) | 1992-11-25 |
TW211004B (fr) | 1993-08-11 |
ZA911721B (en) | 1992-02-26 |
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