IL97002A - A process for the enantioselective synthesis of oxyindoles converted to alkyl used as intermediates in the preparation of physostigmine - Google Patents
A process for the enantioselective synthesis of oxyindoles converted to alkyl used as intermediates in the preparation of physostigmineInfo
- Publication number
- IL97002A IL97002A IL9700291A IL9700291A IL97002A IL 97002 A IL97002 A IL 97002A IL 9700291 A IL9700291 A IL 9700291A IL 9700291 A IL9700291 A IL 9700291A IL 97002 A IL97002 A IL 97002A
- Authority
- IL
- Israel
- Prior art keywords
- oxindole
- enantiomers
- mixture
- solvent
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46988290A | 1990-01-22 | 1990-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL97002A0 IL97002A0 (en) | 1992-03-29 |
| IL97002A true IL97002A (en) | 1994-10-21 |
Family
ID=23865415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9700291A IL97002A (en) | 1990-01-22 | 1991-01-22 | A process for the enantioselective synthesis of oxyindoles converted to alkyl used as intermediates in the preparation of physostigmine |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0438796B1 (sh) |
| JP (1) | JPH0757747B2 (sh) |
| KR (1) | KR0175933B1 (sh) |
| AT (1) | ATE170173T1 (sh) |
| AU (1) | AU631957B2 (sh) |
| CA (1) | CA2034668A1 (sh) |
| CZ (1) | CZ278815B6 (sh) |
| DE (1) | DE69032595T2 (sh) |
| DK (1) | DK0438796T3 (sh) |
| ES (1) | ES2120407T3 (sh) |
| HK (1) | HK1011993A1 (sh) |
| HR (1) | HRP930321B1 (sh) |
| HU (2) | HU9801313D0 (sh) |
| IE (1) | IE910194A1 (sh) |
| IL (1) | IL97002A (sh) |
| LT (1) | LT3982B (sh) |
| NZ (1) | NZ236837A (sh) |
| PH (1) | PH30059A (sh) |
| PT (1) | PT96534B (sh) |
| RU (1) | RU2072354C1 (sh) |
| SG (1) | SG52631A1 (sh) |
| YU (1) | YU9891A (sh) |
| ZA (1) | ZA91410B (sh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE125254T1 (de) * | 1989-09-19 | 1995-08-15 | Hoechst Roussel Pharma | Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen. |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| US5840915A (en) * | 1990-01-22 | 1998-11-24 | Hoechst Marion Roussel, Inc. | Process for the enatioselective synthesis of intermediates used |
| US5521320A (en) * | 1990-01-22 | 1996-05-28 | Hoechst-Roussel Pharmaceuticals Incorporated | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
| US6596870B2 (en) * | 2000-07-13 | 2003-07-22 | Brandeis University | Asymmetric synthetic methods based on phase transfer catalysis |
| US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
| US9126995B2 (en) * | 2011-11-08 | 2015-09-08 | Nissan Chemical Industries, Ltd. | Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound |
| KR102061180B1 (ko) * | 2012-03-14 | 2019-12-31 | 머크 샤프 앤드 돔 코포레이션 | 비대칭 상 이동 촉매로서의 비스-4급 신코나 알칼로이드 염 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578509A (en) | 1983-04-01 | 1986-03-25 | Merck & Co., Inc. | Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis |
| US4791107A (en) | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| ATE125254T1 (de) * | 1989-09-19 | 1995-08-15 | Hoechst Roussel Pharma | Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen. |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| EP0794975B1 (en) | 1994-11-28 | 2000-02-09 | Minnesota Mining And Manufacturing Company | Articles exhibiting durable colour and/or fluorescent properties |
-
1990
- 1990-12-28 EP EP90125644A patent/EP0438796B1/en not_active Expired - Lifetime
- 1990-12-28 AT AT90125644T patent/ATE170173T1/de not_active IP Right Cessation
- 1990-12-28 DE DE69032595T patent/DE69032595T2/de not_active Expired - Fee Related
- 1990-12-28 SG SG1996007048A patent/SG52631A1/en unknown
- 1990-12-28 ES ES90125644T patent/ES2120407T3/es not_active Expired - Lifetime
- 1990-12-28 DK DK90125644T patent/DK0438796T3/da active
-
1991
- 1991-01-18 NZ NZ236837A patent/NZ236837A/xx unknown
- 1991-01-21 JP JP3078153A patent/JPH0757747B2/ja not_active Expired - Lifetime
- 1991-01-21 IE IE019491A patent/IE910194A1/en not_active IP Right Cessation
- 1991-01-21 HU HU9801313A patent/HU9801313D0/hu unknown
- 1991-01-21 CA CA002034668A patent/CA2034668A1/en not_active Abandoned
- 1991-01-21 PH PH41878A patent/PH30059A/en unknown
- 1991-01-21 YU YU9891A patent/YU9891A/sh unknown
- 1991-01-21 CZ CS91123A patent/CZ278815B6/cs not_active IP Right Cessation
- 1991-01-21 RU SU914894301A patent/RU2072354C1/ru active
- 1991-01-21 ZA ZA91410A patent/ZA91410B/xx unknown
- 1991-01-21 HU HU91210A patent/HUT56539A/hu unknown
- 1991-01-21 KR KR1019910000934A patent/KR0175933B1/ko not_active IP Right Cessation
- 1991-01-21 PT PT96534A patent/PT96534B/pt not_active IP Right Cessation
- 1991-01-21 AU AU69496/91A patent/AU631957B2/en not_active Ceased
- 1991-01-22 IL IL9700291A patent/IL97002A/en not_active IP Right Cessation
-
1993
- 1993-03-11 HR HRP-98/91A patent/HRP930321B1/xx not_active IP Right Cessation
- 1993-12-20 LT LTIP1629A patent/LT3982B/lt not_active IP Right Cessation
-
1998
- 1998-12-14 HK HK98113299A patent/HK1011993A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6949691A (en) | 1991-07-25 |
| SG52631A1 (en) | 1998-09-28 |
| PH30059A (en) | 1996-11-08 |
| EP0438796B1 (en) | 1998-08-26 |
| DE69032595D1 (de) | 1998-10-01 |
| HRP930321A2 (en) | 1996-08-31 |
| PT96534B (pt) | 1998-07-31 |
| ZA91410B (en) | 1991-10-30 |
| HK1011993A1 (en) | 1999-07-23 |
| JPH0757747B2 (ja) | 1995-06-21 |
| LTIP1629A (en) | 1995-07-25 |
| ES2120407T3 (es) | 1998-11-01 |
| JPH04342566A (ja) | 1992-11-30 |
| DE69032595T2 (de) | 1999-03-25 |
| DK0438796T3 (da) | 1999-05-25 |
| EP0438796A3 (en) | 1992-03-18 |
| HRP930321B1 (en) | 1999-02-28 |
| HU9801313D0 (en) | 1998-08-28 |
| ATE170173T1 (de) | 1998-09-15 |
| AU631957B2 (en) | 1992-12-10 |
| CA2034668A1 (en) | 1991-07-23 |
| HU910210D0 (en) | 1991-08-28 |
| CZ278815B6 (en) | 1994-07-13 |
| NZ236837A (en) | 1993-03-26 |
| YU9891A (sh) | 1994-06-24 |
| LT3982B (en) | 1996-06-25 |
| KR0175933B1 (ko) | 1999-03-20 |
| KR910014349A (ko) | 1991-08-31 |
| RU2072354C1 (ru) | 1997-01-27 |
| IE910194A1 (en) | 1991-07-31 |
| PT96534A (pt) | 1991-10-15 |
| CS9100123A2 (en) | 1991-09-15 |
| IL97002A0 (en) | 1992-03-29 |
| HUT56539A (en) | 1991-09-30 |
| EP0438796A2 (en) | 1991-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0438796B1 (en) | Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine | |
| US5274117A (en) | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine | |
| US5521320A (en) | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine | |
| JP5822880B2 (ja) | （７ｓ）−１−（３，４−ジメトキシビシクロ［４．２．０］オクタ−１，３，５−トリエン−７−イル）ｎ−メチルメタンアミンの酵素的合成方法、並びにイバブラジン及びその塩の合成における適用 | |
| US5387695A (en) | Process for the chemical resolution of 5-alkoxy-substituted (+)-1,3-dimethyloxindolylethylamines | |
| US5840915A (en) | Process for the enatioselective synthesis of intermediates used | |
| De Tullio et al. | First preparative enantiomer resolution of pirlindole, a potent antidepressant drug |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| MM9K | Patent not in force due to non-payment of renewal fees |