IL96225A0 - Substituted n-(imidazolyl)alkyl alanine derivatives - Google Patents
Substituted n-(imidazolyl)alkyl alanine derivativesInfo
- Publication number
- IL96225A0 IL96225A0 IL96225A IL9622590A IL96225A0 IL 96225 A0 IL96225 A0 IL 96225A0 IL 96225 A IL96225 A IL 96225A IL 9622590 A IL9622590 A IL 9622590A IL 96225 A0 IL96225 A0 IL 96225A0
- Authority
- IL
- Israel
- Prior art keywords
- imidazolyl
- substituted
- alanine derivatives
- alkyl alanine
- angiotensin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43211189A | 1989-11-06 | 1989-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL96225A0 true IL96225A0 (en) | 1991-08-16 |
Family
ID=23714819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL96225A IL96225A0 (en) | 1989-11-06 | 1990-11-02 | Substituted n-(imidazolyl)alkyl alanine derivatives |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0427463B1 (fr) |
| JP (1) | JPH03169866A (fr) |
| KR (1) | KR910009669A (fr) |
| CN (1) | CN1051555A (fr) |
| AT (1) | ATE119524T1 (fr) |
| AU (1) | AU641952B2 (fr) |
| CA (1) | CA2028925A1 (fr) |
| DE (1) | DE69017593T2 (fr) |
| FI (1) | FI905481A0 (fr) |
| HU (1) | HU207851B (fr) |
| IE (1) | IE903976A1 (fr) |
| IL (1) | IL96225A0 (fr) |
| MA (1) | MA22096A1 (fr) |
| MY (1) | MY106159A (fr) |
| NO (1) | NO904799L (fr) |
| NZ (1) | NZ235959A (fr) |
| PL (1) | PL287631A1 (fr) |
| PT (1) | PT95802A (fr) |
| ZA (1) | ZA908843B (fr) |
| ZW (1) | ZW16090A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| NZ238688A (en) * | 1990-06-28 | 1992-05-26 | Smithkline Beecham Corp | Substituted histidines: pharmaceutical compositions, preparation and uses thereof |
| NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
| GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| US5364869A (en) * | 1992-03-09 | 1994-11-15 | Abbott Laboratories | Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists |
| FR2689508B1 (fr) * | 1992-04-01 | 1994-06-17 | Fournier Ind & Sante | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
| US5728842A (en) * | 1992-06-30 | 1998-03-17 | Smithkline Beecham Corporation | Substituted imidazolyl-alkylthio-alkanoic acids |
| GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
| GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| RU2009148050A (ru) | 2007-05-24 | 2011-06-27 | Элдраг С.А. (Gr) | 1, (3, )5-замещенные имидазолы, их применение при лечении гипертензии и способы их получения |
| EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2009016514A2 (fr) * | 2007-08-01 | 2009-02-05 | Eldrug S.A. | Composés |
| GR1006917B (el) * | 2007-10-24 | 2010-07-30 | Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε., | Ανταγωνιστες του υποδοχεα της αγγειοτενσινης ιι με βαση την ισταμινη (και παραγωγα αυτης) με ιδιοτητες καταστολης του συμπαθητικου συστηματος και συνθετικες μεθοδοι στη θεραπεια της υπερτασης και αλλων καρδιοαγγειακων ασθενειων. |
| EP2810951B1 (fr) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2905438A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
| CA2905435A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
| PT3004138T (pt) | 2013-06-05 | 2024-06-18 | Bausch Health Ireland Ltd | Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| CA1334092C (fr) * | 1986-07-11 | 1995-01-24 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii |
| IL85556A (en) * | 1987-03-05 | 1994-06-24 | May & Baker Ltd | Method for exterminating pests using a history of 2-phenylimidazole, certain compounds of this type and a process for their preparation |
| CA1338238C (fr) * | 1988-01-07 | 1996-04-09 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
-
1990
- 1990-10-30 CA CA002028925A patent/CA2028925A1/fr not_active Abandoned
- 1990-10-31 AU AU65649/90A patent/AU641952B2/en not_active Ceased
- 1990-11-01 AT AT90311991T patent/ATE119524T1/de not_active IP Right Cessation
- 1990-11-01 DE DE69017593T patent/DE69017593T2/de not_active Expired - Fee Related
- 1990-11-01 EP EP90311991A patent/EP0427463B1/fr not_active Expired - Lifetime
- 1990-11-01 MA MA22267A patent/MA22096A1/fr unknown
- 1990-11-02 ZW ZW160/90A patent/ZW16090A1/xx unknown
- 1990-11-02 MY MYPI90001926A patent/MY106159A/en unknown
- 1990-11-02 IL IL96225A patent/IL96225A0/xx unknown
- 1990-11-05 NZ NZ235959A patent/NZ235959A/xx unknown
- 1990-11-05 IE IE397690A patent/IE903976A1/en unknown
- 1990-11-05 ZA ZA908843A patent/ZA908843B/xx unknown
- 1990-11-05 FI FI905481A patent/FI905481A0/fi not_active IP Right Cessation
- 1990-11-05 NO NO90904799A patent/NO904799L/no unknown
- 1990-11-05 PL PL28763190A patent/PL287631A1/xx unknown
- 1990-11-05 HU HU907025A patent/HU207851B/hu not_active IP Right Cessation
- 1990-11-06 JP JP2302307A patent/JPH03169866A/ja active Pending
- 1990-11-06 KR KR1019900017998A patent/KR910009669A/ko not_active Application Discontinuation
- 1990-11-06 PT PT95802A patent/PT95802A/pt unknown
- 1990-11-06 CN CN90108945A patent/CN1051555A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69017593D1 (de) | 1995-04-13 |
| PT95802A (pt) | 1991-09-13 |
| MA22096A1 (fr) | 1991-12-31 |
| CA2028925A1 (fr) | 1991-05-07 |
| FI905481A0 (fi) | 1990-11-05 |
| EP0427463A1 (fr) | 1991-05-15 |
| HU907025D0 (en) | 1991-05-28 |
| MY106159A (en) | 1995-03-31 |
| NO904799L (no) | 1991-05-07 |
| NZ235959A (en) | 1991-09-25 |
| JPH03169866A (ja) | 1991-07-23 |
| HUT56077A (en) | 1991-07-29 |
| DE69017593T2 (de) | 1995-07-20 |
| HU207851B (en) | 1993-06-28 |
| ZW16090A1 (en) | 1991-02-27 |
| AU6564990A (en) | 1991-05-09 |
| PL287631A1 (en) | 1991-12-16 |
| AU641952B2 (en) | 1993-10-07 |
| CN1051555A (zh) | 1991-05-22 |
| KR910009669A (ko) | 1991-06-28 |
| EP0427463B1 (fr) | 1995-03-08 |
| ZA908843B (en) | 1992-01-29 |
| IE903976A1 (en) | 1991-05-08 |
| NO904799D0 (no) | 1990-11-05 |
| ATE119524T1 (de) | 1995-03-15 |
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| IL96225A0 (en) | Substituted n-(imidazolyl)alkyl alanine derivatives |