IL95839A - Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
Quinoline derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL95839A IL95839A IL9583990A IL9583990A IL95839A IL 95839 A IL95839 A IL 95839A IL 9583990 A IL9583990 A IL 9583990A IL 9583990 A IL9583990 A IL 9583990A IL 95839 A IL95839 A IL 95839A
- Authority
- IL
- Israel
- Prior art keywords
- dihydro
- oxo
- methyl
- compound
- chlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Measurement Of Radiation (AREA)
- Holo Graphy (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26278289 | 1989-10-06 | ||
| JP32229089 | 1989-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95839A0 IL95839A0 (en) | 1991-06-30 |
| IL95839A true IL95839A (en) | 1995-03-15 |
Family
ID=26545706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9583990A IL95839A (en) | 1989-10-06 | 1990-09-28 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5223513A (cs) |
| EP (1) | EP0421456B1 (cs) |
| KR (1) | KR910007883A (cs) |
| CN (1) | CN1050715A (cs) |
| AT (1) | ATE116301T1 (cs) |
| AU (1) | AU629048B2 (cs) |
| CA (1) | CA2026890C (cs) |
| DE (1) | DE69015541T2 (cs) |
| FI (1) | FI904915A7 (cs) |
| HU (1) | HUT55364A (cs) |
| IE (1) | IE903454A1 (cs) |
| IL (1) | IL95839A (cs) |
| NO (1) | NO904300L (cs) |
| NZ (1) | NZ235582A (cs) |
| PT (1) | PT95515A (cs) |
| RU (1) | RU2001910C1 (cs) |
| TW (1) | TW205037B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| CA2108014A1 (en) * | 1991-04-26 | 1992-10-27 | Ernest S. Hamanaka | 4-aryl-3-(heteroarylureido)quinoline derivatives |
| WO1993015058A1 (en) * | 1992-01-23 | 1993-08-05 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| TW241258B (cs) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| SK142694A3 (en) * | 1992-05-28 | 1995-06-07 | Pfizer | N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use |
| NO179904C (no) * | 1992-09-04 | 1997-01-08 | Takeda Chemical Industries Ltd | Kondenserte heterocykliske forbindelser og deres anvendelse |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| TW263498B (cs) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| JP2001513560A (ja) * | 1997-08-28 | 2001-09-04 | ブリストル−マイヤーズ スクイブ カンパニー | ４−アリール−３−アミノキノリン−２−オン誘導体カリウムチャンネル調節剤 |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| CA2321237A1 (en) | 1998-02-25 | 1999-09-02 | Masami Muraoka | Pyridone derivatives and process for producing the same |
| EP1133474B1 (en) * | 1998-12-04 | 2007-02-21 | Bristol-Myers Squibb Company | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators |
| HRP20020717A2 (en) | 2000-02-02 | 2003-12-31 | Warner Lambert Co | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders |
| JP4300457B2 (ja) * | 2001-03-02 | 2009-07-22 | 住友化学株式会社 | キノリン−３−カルボン酸化合物の製造方法 |
| HU225777B1 (en) * | 2001-04-30 | 2007-08-28 | Pfizer Prod Inc | Compounds useful as intermediates for 4-aminoquinoline derivatwes and process for producing them |
| EP1667973B1 (en) * | 2003-09-23 | 2013-12-04 | Merck Sharp & Dohme Corp. | Quinoline potassium channel inhibitors |
| AU2012331289B2 (en) * | 2011-11-04 | 2017-07-13 | F. Hoffmann-La Roche Ag | New aryl-quinoline derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1216878B (de) * | 1963-04-02 | 1966-05-18 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins |
| NO133758C (cs) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| JPS555502B1 (cs) * | 1971-07-31 | 1980-02-07 | ||
| US4530931A (en) * | 1983-01-03 | 1985-07-23 | Usv Pharmaceutical Corp. | 8-Quinoline carbanilates for the inhibition of lipolysis |
| EP0166354B1 (en) * | 1984-06-26 | 1992-08-05 | Merck & Co. Inc. | Benzofused lactam compounds and pharmaceutical compositions containing them |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
-
1990
- 1990-09-20 TW TW079107912A patent/TW205037B/zh active
- 1990-09-25 IE IE345490A patent/IE903454A1/en unknown
- 1990-09-25 US US07/587,795 patent/US5223513A/en not_active Expired - Fee Related
- 1990-09-28 IL IL9583990A patent/IL95839A/en not_active IP Right Cessation
- 1990-09-28 AU AU63707/90A patent/AU629048B2/en not_active Ceased
- 1990-10-03 NO NO90904300A patent/NO904300L/no unknown
- 1990-10-04 CA CA002026890A patent/CA2026890C/en not_active Expired - Fee Related
- 1990-10-04 PT PT95515A patent/PT95515A/pt not_active Application Discontinuation
- 1990-10-05 FI FI904915A patent/FI904915A7/fi not_active Application Discontinuation
- 1990-10-05 CN CN90108222A patent/CN1050715A/zh active Pending
- 1990-10-05 EP EP90119128A patent/EP0421456B1/en not_active Expired - Lifetime
- 1990-10-05 DE DE69015541T patent/DE69015541T2/de not_active Expired - Fee Related
- 1990-10-05 AT AT90119128T patent/ATE116301T1/de not_active IP Right Cessation
- 1990-10-05 NZ NZ235582A patent/NZ235582A/en unknown
- 1990-10-05 RU SU904831426A patent/RU2001910C1/ru active
- 1990-10-05 HU HU906360A patent/HUT55364A/hu unknown
- 1990-10-06 KR KR1019900015908A patent/KR910007883A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL95839A0 (en) | 1991-06-30 |
| HUT55364A (en) | 1991-05-28 |
| DE69015541T2 (de) | 1995-06-01 |
| EP0421456B1 (en) | 1994-12-28 |
| US5223513A (en) | 1993-06-29 |
| KR910007883A (ko) | 1991-05-30 |
| AU6370790A (en) | 1991-04-11 |
| DE69015541D1 (de) | 1995-02-09 |
| JPH03223254A (ja) | 1991-10-02 |
| PT95515A (pt) | 1991-08-14 |
| NO904300D0 (no) | 1990-10-03 |
| CA2026890C (en) | 2001-09-18 |
| AU629048B2 (en) | 1992-09-24 |
| FI904915A0 (fi) | 1990-10-05 |
| CA2026890A1 (en) | 1991-04-07 |
| CN1050715A (zh) | 1991-04-17 |
| HU906360D0 (en) | 1991-04-29 |
| TW205037B (cs) | 1993-05-01 |
| IE903454A1 (en) | 1991-04-10 |
| EP0421456A2 (en) | 1991-04-10 |
| EP0421456A3 (en) | 1991-05-29 |
| ATE116301T1 (de) | 1995-01-15 |
| RU2001910C1 (ru) | 1993-10-30 |
| FI904915A7 (fi) | 1991-04-07 |
| NZ235582A (en) | 1992-03-26 |
| NO904300L (no) | 1991-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2026890C (en) | Quinoline derivatives, their production and use | |
| EP0354994B1 (en) | Quinoline derivatives, their production and use | |
| US3702849A (en) | 4-(isoquinolin-1-yl) piperazine-1-carboxylic acid esters | |
| US5700810A (en) | Condensed heterocyclic compounds, their production and use | |
| NO171785B (no) | Analogifremgangsmaate for fremstilling av terapeutisk virksomme kinazolinderivater | |
| CA2071224C (en) | Quinoline derivatives, their production and use | |
| NO794135L (no) | Substituerte 4(3h)-kinazolinoner, fremgangsmaate ved fremstilling og anvendelse av disse | |
| US5278186A (en) | Chromene derivatives, their production and use | |
| US5264454A (en) | Certain 2-oxo-tetrahydro-cycloalkyl-benzopyran-3yl ureas having acyl-CoA-cholesterol acyl transferase inhibitory activity | |
| JPH0710844A (ja) | 縮合複素環化合物、その製造法および剤 | |
| EP0138491A2 (en) | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters | |
| PL88788B1 (en) | Triazolo-isoindole and triazolo-isoquinoline derivatives and their manufacture and uses[gb1477302a] | |
| HINO et al. | Synthesis and pharmacological activities of 3-phenyl-2-(1-piperazinyl) quinolines and related compounds | |
| IE51542B1 (en) | Therapeutic agents | |
| RU1838301C (ru) | Способ получени производного хинолина или его соли | |
| GB2085441A (en) | Therapeutic agents | |
| JP3004041B2 (ja) | キノリン誘導体、その製法および用途 | |
| JPH0753714B2 (ja) | Ａｃａｔ阻害剤、キノリン誘導体及びその製造法 | |
| CA1230123A (en) | 3-alkyl-8-chloro-5,6-dihydrofuro-¬3,2-f|-1,2- benzisoxazole-6-carboxylic acids | |
| KR820000099B1 (ko) | 피리도[2, 1-b] 퀴나졸린 유도체의 제조방법 | |
| Žinić et al. | Synthesis of some 7‐α‐carboxyethyl‐1, 3‐dihydro‐(2H)‐1, 4‐benzodiazepin‐2‐ones | |
| CN101870692A (zh) | 一种新型哌嗪基哒嗪类化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |