IL95692A - 5-דקאנוליד ו- 5-דודקאנוליד טבעיים ותהליך לייצורם - Google Patents
5-דקאנוליד ו- 5-דודקאנוליד טבעיים ותהליך לייצורםInfo
- Publication number
- IL95692A IL95692A IL9569290A IL9569290A IL95692A IL 95692 A IL95692 A IL 95692A IL 9569290 A IL9569290 A IL 9569290A IL 9569290 A IL9569290 A IL 9569290A IL 95692 A IL95692 A IL 95692A
- Authority
- IL
- Israel
- Prior art keywords
- natural
- decanolide
- olide
- process according
- dodecanolide
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 30
- GHBSPIPJMLAMEP-UHFFFAOYSA-N 6-pentyloxan-2-one Chemical compound CCCCCC1CCCC(=O)O1 GHBSPIPJMLAMEP-UHFFFAOYSA-N 0.000 title claims description 27
- QRPLZGZHJABGRS-UHFFFAOYSA-N xi-5-Dodecanolide Chemical compound CCCCCCCC1CCCC(=O)O1 QRPLZGZHJABGRS-UHFFFAOYSA-N 0.000 title claims description 11
- 238000004519 manufacturing process Methods 0.000 title description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000000758 substrate Substances 0.000 claims description 9
- 239000011942 biocatalyst Substances 0.000 claims description 8
- 230000002210 biocatalytic effect Effects 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- 241000233866 Fungi Species 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- NEDIAPMWNCQWNW-UHFFFAOYSA-N massoia lactone Chemical compound CCCCCC1CC=CC(=O)O1 NEDIAPMWNCQWNW-UHFFFAOYSA-N 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 241000094551 Amyloporia xantha Species 0.000 claims description 3
- 229920000858 Cyclodextrin Polymers 0.000 claims description 3
- 235000007685 Pleurotus columbinus Nutrition 0.000 claims description 3
- 240000001462 Pleurotus ostreatus Species 0.000 claims description 3
- 235000001603 Pleurotus ostreatus Nutrition 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- XPTXKXKPWKNYKB-UHFFFAOYSA-N 5-Hydroxy-2-dodecensaeure-delta-lacton Natural products CCCCCCCC1CC=CC(=O)O1 XPTXKXKPWKNYKB-UHFFFAOYSA-N 0.000 claims 2
- 241001624567 Erronea Species 0.000 claims 1
- 241000995768 Ischnoderma Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 14
- 239000000047 product Substances 0.000 description 10
- 239000002028 Biomass Substances 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 238000006722 reduction reaction Methods 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 5
- 125000000422 delta-lactone group Chemical group 0.000 description 5
- 238000005984 hydrogenation reaction Methods 0.000 description 5
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000222478 Bjerkandera adusta Species 0.000 description 2
- 241000995766 Ischnoderma benzoinum Species 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 241000222640 Polyporus Species 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 150000001728 carbonyl compounds Chemical class 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 125000000457 gamma-lactone group Chemical group 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000036983 biotransformation Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000011916 stereoselective reduction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/205—Heterocyclic compounds
- A23L27/2052—Heterocyclic compounds having oxygen or sulfur as the only hetero atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/24—Synthetic spices, flavouring agents or condiments prepared by fermentation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89202426 | 1989-09-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95692A0 IL95692A0 (en) | 1991-06-30 |
| IL95692A true IL95692A (he) | 1994-12-29 |
Family
ID=8202474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9569290A IL95692A (he) | 1989-09-28 | 1990-09-14 | 5-דקאנוליד ו- 5-דודקאנוליד טבעיים ותהליך לייצורם |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5128261A (he) |
| EP (1) | EP0425001B1 (he) |
| JP (1) | JPH03155792A (he) |
| AU (1) | AU629694B2 (he) |
| CA (1) | CA2025678C (he) |
| DE (1) | DE69024910T2 (he) |
| DK (1) | DK0425001T3 (he) |
| ES (1) | ES2081916T3 (he) |
| GR (1) | GR3019257T3 (he) |
| IL (1) | IL95692A (he) |
| NZ (1) | NZ235317A (he) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1263126B (it) * | 1992-06-22 | 1996-07-30 | Claudio Fuganti | Procedimento per la preparazione di delta lattoni saturi per bioidro-genazione dei corrispondenti composti insaturi naturali mediante microrganismi. |
| JP3564237B2 (ja) * | 1996-08-02 | 2004-09-08 | 長谷川香料株式会社 | δ−デカラクトンの製造方法 |
| EP0899342B1 (en) * | 1997-08-27 | 2004-05-06 | Firmenich Sa | Process for the biotechnological production of Delta-decalactone and Delta-dodecalactone |
| US6117835A (en) * | 1998-04-23 | 2000-09-12 | International Flavors & Fragrances Inc | Process for preparing saturated lactones, products produced therefrom and organoleptic uses of said products |
| WO2004003213A1 (ja) * | 2002-06-28 | 2004-01-08 | Takasago International Corporation | ラクトン類の製造方法 |
| JP4641455B2 (ja) * | 2005-06-17 | 2011-03-02 | ニチコン株式会社 | 電解コンデンサの駆動用電解液 |
| ES2623761B1 (es) * | 2016-01-12 | 2018-01-19 | Centro De Investigacion Biomedica En Red | Composición farmacéutica que comprende 5-dodecanolida, su preparación y su uso |
| CN111635865B (zh) * | 2020-04-24 | 2022-03-29 | 厦门欧米克生物科技有限公司 | 一种生物还原马索亚油制备天然丁位癸内酯及丁位十二内酯的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4020185A (en) * | 1972-06-05 | 1977-04-26 | Borden, Inc. | Starter culture media containing whey |
| CH576239A5 (he) * | 1972-12-18 | 1976-06-15 | Givaudan & Cie Sa | |
| US4110476A (en) * | 1977-01-10 | 1978-08-29 | Johnson/Rhodes Cultured Foods, Inc. | Preparation of liquid and frozen yogurt products |
| US4293573A (en) * | 1979-03-30 | 1981-10-06 | Wisconsin Alumni Research Foundation | Preparation of frozen yogurt |
| US4289788A (en) * | 1979-06-25 | 1981-09-15 | M P Food Technology, Inc. | Instant yogurt composition |
| US4743453A (en) * | 1984-11-13 | 1988-05-10 | Stauffer Chemical Co. | Fermentation of whey to produce propionic acid |
| GB8618351D0 (en) * | 1986-07-28 | 1986-09-03 | Unilever Plc | Lactones |
-
1990
- 1990-09-13 US US07/582,451 patent/US5128261A/en not_active Expired - Fee Related
- 1990-09-14 IL IL9569290A patent/IL95692A/he not_active IP Right Cessation
- 1990-09-14 NZ NZ235317A patent/NZ235317A/xx unknown
- 1990-09-19 CA CA002025678A patent/CA2025678C/en not_active Expired - Fee Related
- 1990-09-27 DK DK90202561.8T patent/DK0425001T3/da active
- 1990-09-27 DE DE69024910T patent/DE69024910T2/de not_active Expired - Fee Related
- 1990-09-27 EP EP90202561A patent/EP0425001B1/en not_active Expired - Lifetime
- 1990-09-27 AU AU63293/90A patent/AU629694B2/en not_active Ceased
- 1990-09-27 ES ES90202561T patent/ES2081916T3/es not_active Expired - Lifetime
- 1990-09-28 JP JP2260333A patent/JPH03155792A/ja active Pending
-
1996
- 1996-03-12 GR GR960400658T patent/GR3019257T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69024910D1 (de) | 1996-02-29 |
| AU6329390A (en) | 1991-04-11 |
| EP0425001A1 (en) | 1991-05-02 |
| GR3019257T3 (en) | 1996-06-30 |
| CA2025678A1 (en) | 1991-03-29 |
| DE69024910T2 (de) | 1996-06-20 |
| CA2025678C (en) | 2001-08-14 |
| US5128261A (en) | 1992-07-07 |
| DK0425001T3 (da) | 1996-05-20 |
| ES2081916T3 (es) | 1996-03-16 |
| IL95692A0 (en) | 1991-06-30 |
| JPH03155792A (ja) | 1991-07-03 |
| NZ235317A (en) | 1993-04-28 |
| AU629694B2 (en) | 1992-10-08 |
| EP0425001B1 (en) | 1996-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |