IL95321A - תולדות 4-מותמרות של g-)h]-014- פנותיאזין-01-איל(אלקיל[ -2-אוקסו-1-אוקסא-8-אזאספירו ]4,5[ דקאן, הכנתן ותכשירי רוקחות המכילים אותן - Google Patents
תולדות 4-מותמרות של g-)h]-014- פנותיאזין-01-איל(אלקיל[ -2-אוקסו-1-אוקסא-8-אזאספירו ]4,5[ דקאן, הכנתן ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL95321A IL95321A IL9532190A IL9532190A IL95321A IL 95321 A IL95321 A IL 95321A IL 9532190 A IL9532190 A IL 9532190A IL 9532190 A IL9532190 A IL 9532190A IL 95321 A IL95321 A IL 95321A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- group
- defined above
- oxo
- derivative
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 title claims description 7
- SEUNTAIZLCAWDW-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decan-2-one Chemical class O1C(=O)CCC11CCNCC1 SEUNTAIZLCAWDW-UHFFFAOYSA-N 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 91
- 238000000034 method Methods 0.000 claims abstract description 42
- 230000008569 process Effects 0.000 claims abstract description 31
- 239000002253 acid Substances 0.000 claims abstract description 27
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims abstract description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 12
- 239000001257 hydrogen Substances 0.000 claims abstract description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 9
- 125000002837 carbocyclic group Chemical group 0.000 claims abstract description 7
- 125000003118 aryl group Chemical group 0.000 claims abstract description 4
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- 208000020016 psychiatric disease Diseases 0.000 claims abstract description 3
- 208000026935 allergic disease Diseases 0.000 claims abstract 2
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- 239000000654 additive Substances 0.000 claims description 7
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- GVZFMFFUAZKMOB-UHFFFAOYSA-N 4-ethynylpiperidin-4-ol Chemical class C#CC1(O)CCNCC1 GVZFMFFUAZKMOB-UHFFFAOYSA-N 0.000 claims description 6
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- 239000000969 carrier Substances 0.000 claims description 6
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- VWADBHVASFOEHX-UHFFFAOYSA-N 1-(4-hydroxypiperidin-4-yl)ethanone Chemical class CC(=O)C1(O)CCNCC1 VWADBHVASFOEHX-UHFFFAOYSA-N 0.000 claims description 4
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- 238000002156 mixing Methods 0.000 claims description 2
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- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 claims 4
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- 239000000460 chlorine Substances 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
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- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical group C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- 125000004561 phenothiazin-10-yl group Chemical group C1=CC=CC=2SC3=CC=CC=C3N(C12)* 0.000 claims 1
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
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- 238000001704 evaporation Methods 0.000 description 19
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- 230000008020 evaporation Effects 0.000 description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU894093A HU204529B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95321A0 IL95321A0 (en) | 1991-06-30 |
| IL95321A true IL95321A (he) | 1994-02-27 |
Family
ID=10966862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9532190A IL95321A (he) | 1989-08-10 | 1990-08-09 | תולדות 4-מותמרות של g-)h]-014- פנותיאזין-01-איל(אלקיל[ -2-אוקסו-1-אוקסא-8-אזאספירו ]4,5[ דקאן, הכנתן ותכשירי רוקחות המכילים אותן |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0414422B1 (he) |
| JP (1) | JPH0377885A (he) |
| KR (1) | KR950001022B1 (he) |
| AT (1) | ATE103921T1 (he) |
| AU (1) | AU623545B2 (he) |
| DD (1) | DD299427A5 (he) |
| DE (1) | DE69007905T2 (he) |
| DK (1) | DK0414422T3 (he) |
| ES (1) | ES2052181T3 (he) |
| HU (1) | HU204529B (he) |
| IL (1) | IL95321A (he) |
| NZ (1) | NZ234845A (he) |
| ZA (1) | ZA906301B (he) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| HU204530B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
| KR940003491B1 (ko) * | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| HU204054B (en) * | 1989-08-10 | 1991-11-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same |
| FR2691459B1 (fr) * | 1992-05-25 | 1995-06-09 | Adir | Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| JP5767429B2 (ja) | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | 固体分散剤中の結晶化阻害剤 |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| EP1672973B1 (en) | 2003-09-26 | 2013-01-09 | Sony Computer Entertainment Inc. | Portable electronic device |
| CN100497346C (zh) | 2004-02-10 | 2009-06-10 | 弗·哈夫曼-拉罗切有限公司 | 趋化因子ccr5受体调控剂 |
| EP2142555A1 (en) | 2007-03-29 | 2010-01-13 | F. Hoffmann-Roche AG | Heterocyclic antiviral compounds |
| CA3094481A1 (en) | 2018-04-06 | 2019-10-10 | Camp4 Therapeutics Corporation | Phenothiazine derivatives and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256404A (en) * | 1968-06-07 | 1971-12-08 | Dainippon Pharmaceutical Co | 0-oxa-3,8-diazaspiro(4,5)decan-2,4-diones |
| DE2118339A1 (de) * | 1971-04-15 | 1972-10-26 | Yoshitomi Pharmaceutical Industries Ltd, Osaka (Japan) | Pipendinspiroverbindungen |
| US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
| FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
-
1989
- 1989-08-10 HU HU894093A patent/HU204529B/hu not_active IP Right Cessation
-
1990
- 1990-08-09 AT AT90308785T patent/ATE103921T1/de not_active IP Right Cessation
- 1990-08-09 NZ NZ234845A patent/NZ234845A/en unknown
- 1990-08-09 DK DK90308785.6T patent/DK0414422T3/da active
- 1990-08-09 DE DE69007905T patent/DE69007905T2/de not_active Expired - Fee Related
- 1990-08-09 JP JP2209359A patent/JPH0377885A/ja active Pending
- 1990-08-09 ES ES90308785T patent/ES2052181T3/es not_active Expired - Lifetime
- 1990-08-09 DD DD90343353A patent/DD299427A5/de not_active IP Right Cessation
- 1990-08-09 AU AU60802/90A patent/AU623545B2/en not_active Ceased
- 1990-08-09 IL IL9532190A patent/IL95321A/he not_active IP Right Cessation
- 1990-08-09 ZA ZA906301A patent/ZA906301B/xx unknown
- 1990-08-09 EP EP90308785A patent/EP0414422B1/en not_active Expired - Lifetime
- 1990-08-09 KR KR1019900012255A patent/KR950001022B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE103921T1 (de) | 1994-04-15 |
| DE69007905D1 (de) | 1994-05-11 |
| NZ234845A (en) | 1992-03-26 |
| IL95321A0 (en) | 1991-06-30 |
| EP0414422B1 (en) | 1994-04-06 |
| AU623545B2 (en) | 1992-05-14 |
| DK0414422T3 (da) | 1994-05-16 |
| DE69007905T2 (de) | 1994-07-21 |
| ZA906301B (en) | 1991-06-26 |
| KR910004633A (ko) | 1991-03-29 |
| ES2052181T3 (es) | 1994-07-01 |
| KR950001022B1 (ko) | 1995-02-07 |
| JPH0377885A (ja) | 1991-04-03 |
| HUT55784A (en) | 1991-06-28 |
| EP0414422A2 (en) | 1991-02-27 |
| EP0414422A3 (en) | 1991-07-24 |
| DD299427A5 (de) | 1992-04-16 |
| AU6080290A (en) | 1991-02-14 |
| HU204529B (en) | 1992-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |