IL93156A - A monoclonal antibody to a cell surface glycoprotein antigen that binds to tumors of human tissues and similar antibodies - Google Patents
A monoclonal antibody to a cell surface glycoprotein antigen that binds to tumors of human tissues and similar antibodiesInfo
- Publication number
- IL93156A IL93156A IL9315690A IL9315690A IL93156A IL 93156 A IL93156 A IL 93156A IL 9315690 A IL9315690 A IL 9315690A IL 9315690 A IL9315690 A IL 9315690A IL 93156 A IL93156 A IL 93156A
- Authority
- IL
- Israel
- Prior art keywords
- monoclonal antibody
- antibody
- antigen
- cells
- tumor cells
- Prior art date
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
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Landscapes
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US07/312,640 US5134075A (en) | 1989-02-17 | 1989-02-17 | Monoclonal antibody to novel antigen associated with human tumors |
Publications (2)
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IL93156A0 IL93156A0 (en) | 1990-11-05 |
IL93156A true IL93156A (en) | 1995-07-31 |
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IL9315690A IL93156A (en) | 1989-02-17 | 1990-01-23 | A monoclonal antibody to a cell surface glycoprotein antigen that binds to tumors of human tissues and similar antibodies |
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US (1) | US5134075A (de) |
EP (1) | EP0458878B1 (de) |
JP (1) | JPH04503307A (de) |
KR (1) | KR910700077A (de) |
AT (1) | ATE142108T1 (de) |
AU (1) | AU629617B2 (de) |
CA (1) | CA2010253A1 (de) |
DE (1) | DE69028388D1 (de) |
DK (1) | DK0458878T3 (de) |
FI (1) | FI913891A0 (de) |
GR (1) | GR1000454B (de) |
IL (1) | IL93156A (de) |
NO (1) | NO913211L (de) |
NZ (1) | NZ232554A (de) |
PT (1) | PT93167B (de) |
WO (1) | WO1990009197A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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US5171665A (en) * | 1989-04-17 | 1992-12-15 | Oncogen | Monoclonal antibody to novel antigen associated with human tumors |
IE62496B1 (en) * | 1990-04-19 | 1995-02-08 | Res Dev Foundation | Antibody conjugates for treatment of neoplastic disease |
US5434075A (en) * | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
US5773280A (en) * | 1992-03-20 | 1998-06-30 | The Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
US5994088A (en) * | 1991-03-08 | 1999-11-30 | Board Of Trustees Of The University Of Illinois | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein |
US5342774A (en) * | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
WO1993015405A1 (en) | 1992-01-29 | 1993-08-05 | Sci-Clone, Inc. | Carcinoma associated antigen (sk1) monoclonal antibodies against sk1, methods of producing these antibodies and use therfor |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
AU6162794A (en) * | 1993-01-22 | 1994-08-15 | Hygeia Pharmaceuticals, Inc. | Carcinoma associated antigen (ng1) monoclonal antibodies against ng1, methods of producing these antibodies and use therefor |
US7097839B1 (en) | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
US5589579A (en) * | 1994-07-19 | 1996-12-31 | Cytoclonal Pharmaceutics, Inc. | Gene sequence and probe for a marker of non-small cell lung carinoma |
US5648222A (en) * | 1994-07-27 | 1997-07-15 | The Trustees Of Columbia University In The City Of New York | Method for preserving cells, and uses of said method |
US5935821A (en) * | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
US5977316A (en) * | 1995-01-17 | 1999-11-02 | The Board Of Trustees Of The University Of Kentucky | Monoclonal antibody 1A7 and related polypeptides |
US5612030A (en) * | 1995-01-17 | 1997-03-18 | University Of Kentucky Research Foundation | Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
US6949244B1 (en) | 1995-12-20 | 2005-09-27 | The Board Of Trustees Of The University Of Kentucky | Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof |
US5744585A (en) * | 1995-03-16 | 1998-04-28 | Medenica; Rajko D. | Human monoclonal antibody against lung carcinoma |
US6132730A (en) | 1997-01-22 | 2000-10-17 | Board Of Regents, The University Of Texas System | Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment |
US20020098190A1 (en) * | 1997-06-13 | 2002-07-25 | Malaya Chatterjee | Compositions and methods for treating tumors bearing HMFG and CEA antigens |
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AU750414B2 (en) | 1998-07-13 | 2002-07-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
PT1520588E (pt) | 1998-07-13 | 2015-03-31 | Univ Texas | Usos de anticorpos para amino fosfolípidos para o tratamento do cancro |
US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
US7829064B2 (en) * | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
US20020098516A1 (en) * | 2000-10-03 | 2002-07-25 | Boystown National Research Hospital | Immunodiagnostic determination of usher syndrome type IIA |
ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
DK1414471T3 (da) | 2001-07-17 | 2012-07-16 | Res Dev Foundation | Terapeutiske midler omfattende pro-apoptotiske proteiner |
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CN107428837A (zh) | 2015-04-22 | 2017-12-01 | 免疫医疗公司 | 循环trop‑2阳性癌细胞的分离、检测、诊断和/或鉴定 |
US10195175B2 (en) | 2015-06-25 | 2019-02-05 | Immunomedics, Inc. | Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors |
US20170224837A1 (en) | 2016-02-10 | 2017-08-10 | Immunomedics, Inc. | Combination of abcg2 inhibitors with sacituzumab govitecan (immu-132) overcomes resistance to sn-38 in trop-2 expressing cancers |
JP7379795B2 (ja) | 2016-04-27 | 2023-11-15 | イミューノメディクス、インコーポレイテッド | チェックポイント阻害薬に再発/耐性を示す腫瘍を治療するための抗Trop-2-SN-38抗体薬物複合体の効果 |
WO2018183041A1 (en) | 2017-03-27 | 2018-10-04 | Immunomedics, Inc. | Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor |
WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4713352A (en) * | 1981-08-31 | 1987-12-15 | Sloan-Kettering Institute For Cancer Reseach | Monoclonal antibody panel for early diagnosis and therapy of renal carcinoma |
US4612282A (en) * | 1981-12-15 | 1986-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Monoclonal antibodies reactive with human breast cancer |
US4507391A (en) * | 1982-04-02 | 1985-03-26 | Sloan-Kettering Institute For Cancer Research | Method for detecting the presence of GD3 ganglioside |
US4713351A (en) * | 1983-01-28 | 1987-12-15 | The University Of Rochester | Monoclonal antibody directed to an antigen derived from human ovarian tumors and a radioimmunoassay using the antibody |
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
ZA858371B (en) * | 1984-11-02 | 1987-03-25 | Oncogen | Monoclonal antibodies for human non-small cell lung carcinomas |
US4708930A (en) * | 1984-11-09 | 1987-11-24 | Coulter Corporation | Monoclonal antibody to a human carcinoma tumor associated antigen |
US5185432A (en) * | 1986-02-26 | 1993-02-09 | Oncogen | Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas |
EP0323802A3 (de) * | 1987-12-24 | 1989-07-26 | Sandoz Ag | Gegen Lungenkrebs gerichtete monoklonale Antikörper und Zelloberflächenantigen davon |
US5171666A (en) * | 1988-04-22 | 1992-12-15 | Eli Lilly And Company | Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas |
-
1989
- 1989-02-17 US US07/312,640 patent/US5134075A/en not_active Expired - Lifetime
-
1990
- 1990-01-23 DE DE69028388T patent/DE69028388D1/de not_active Expired - Lifetime
- 1990-01-23 DK DK90903653.5T patent/DK0458878T3/da active
- 1990-01-23 EP EP90903653A patent/EP0458878B1/de not_active Expired - Lifetime
- 1990-01-23 KR KR1019900702278A patent/KR910700077A/ko not_active Application Discontinuation
- 1990-01-23 IL IL9315690A patent/IL93156A/en not_active IP Right Cessation
- 1990-01-23 JP JP2503697A patent/JPH04503307A/ja active Pending
- 1990-01-23 AT AT90903653T patent/ATE142108T1/de not_active IP Right Cessation
- 1990-01-23 WO PCT/US1990/000407 patent/WO1990009197A1/en active IP Right Grant
- 1990-01-23 AU AU51508/90A patent/AU629617B2/en not_active Ceased
- 1990-02-15 PT PT93167A patent/PT93167B/pt not_active IP Right Cessation
- 1990-02-15 NZ NZ232554A patent/NZ232554A/xx unknown
- 1990-02-16 CA CA002010253A patent/CA2010253A1/en not_active Abandoned
- 1990-02-16 GR GR900100121A patent/GR1000454B/el unknown
-
1991
- 1991-08-16 FI FI913891A patent/FI913891A0/fi not_active Application Discontinuation
- 1991-08-16 NO NO91913211A patent/NO913211L/no unknown
Also Published As
Publication number | Publication date |
---|---|
GR1000454B (el) | 1992-07-30 |
CA2010253A1 (en) | 1990-08-17 |
IL93156A0 (en) | 1990-11-05 |
DE69028388D1 (de) | 1996-10-10 |
WO1990009197A1 (en) | 1990-08-23 |
GR900100121A (en) | 1991-06-28 |
NO913211D0 (no) | 1991-08-16 |
PT93167A (pt) | 1990-08-31 |
US5134075A (en) | 1992-07-28 |
NO913211L (no) | 1991-08-16 |
EP0458878A4 (en) | 1992-04-08 |
EP0458878A1 (de) | 1991-12-04 |
ATE142108T1 (de) | 1996-09-15 |
FI913891A0 (fi) | 1991-08-16 |
AU5150890A (en) | 1990-09-05 |
NZ232554A (en) | 1993-01-27 |
PT93167B (pt) | 1996-03-29 |
DK0458878T3 (da) | 1996-09-23 |
EP0458878B1 (de) | 1996-09-04 |
AU629617B2 (en) | 1992-10-08 |
KR910700077A (ko) | 1991-03-13 |
JPH04503307A (ja) | 1992-06-18 |
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