IL92054A - Spiro-isoquinoline-pyrrolidine tetra and their analogues, their preparations and pharmaceutical preparations containing them - Google Patents

Spiro-isoquinoline-pyrrolidine tetra and their analogues, their preparations and pharmaceutical preparations containing them

Info

Publication number
IL92054A
IL92054A IL9205489A IL9205489A IL92054A IL 92054 A IL92054 A IL 92054A IL 9205489 A IL9205489 A IL 9205489A IL 9205489 A IL9205489 A IL 9205489A IL 92054 A IL92054 A IL 92054A
Authority
IL
Israel
Prior art keywords
pharmaceutically acceptable
pyrrolidine
tetrone
bromo
formula
Prior art date
Application number
IL9205489A
Other languages
English (en)
Hebrew (he)
Other versions
IL92054A0 (en
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL92054A0 publication Critical patent/IL92054A0/xx
Publication of IL92054A publication Critical patent/IL92054A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL9205489A 1988-10-20 1989-10-19 Spiro-isoquinoline-pyrrolidine tetra and their analogues, their preparations and pharmaceutical preparations containing them IL92054A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26043488A 1988-10-20 1988-10-20
US07/357,563 US4927831A (en) 1988-10-20 1989-05-26 Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
IL92054A0 IL92054A0 (en) 1990-07-12
IL92054A true IL92054A (en) 1994-07-31

Family

ID=26947989

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9205489A IL92054A (en) 1988-10-20 1989-10-19 Spiro-isoquinoline-pyrrolidine tetra and their analogues, their preparations and pharmaceutical preparations containing them

Country Status (9)

Country Link
US (1) US4927831A (ja)
JP (1) JP2888559B2 (ja)
KR (1) KR0143998B1 (ja)
CA (1) CA1337351C (ja)
DK (1) DK170702B1 (ja)
HU (1) HU206211B (ja)
IL (1) IL92054A (ja)
PH (1) PH27278A (ja)
PT (1) PT92025B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428066A (en) * 1989-03-08 1995-06-27 Larner; Joseph Method of reducing elevated blood sugar in humans
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5045544A (en) * 1990-05-21 1991-09-03 American Home Products Corporation N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5093496A (en) * 1990-05-21 1992-03-03 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5081241A (en) * 1990-10-11 1992-01-14 American Home Products Corporation Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5130425A (en) * 1990-10-12 1992-07-14 American Home Products Corporation Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5169948A (en) * 1991-05-22 1992-12-08 American Home Products Corporation Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
ATE248187T1 (de) * 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
CA2362481C (en) * 1999-03-03 2008-11-04 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US6777048B2 (en) 2002-12-18 2004-08-17 Eastman Chemical Company Polyester compositions containing silicon carbide
EP1663193B1 (en) * 2003-09-12 2012-04-04 Merck Serono SA Sulfonamide derivatives for the treatment of diabetes
ATE378047T1 (de) * 2003-09-12 2007-11-15 Serono Lab Benzothiazol-derivate zur behandlung von diabetes
US7947851B2 (en) * 2004-04-07 2011-05-24 Merck Serono Sa 1,1′-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors
EP1778275A2 (en) * 2004-08-12 2007-05-02 Wyeth Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5241587U (ja) * 1975-09-18 1977-03-24
JPS5241586U (ja) * 1975-09-18 1977-03-24
FR2525603A1 (fr) * 1982-04-27 1983-10-28 Adir Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique
FR2544317B2 (fr) * 1983-04-12 1985-07-05 Adir Benzoazacycloalkyl-spiro-imidazolidines et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
US4927831A (en) 1990-05-22
JP2888559B2 (ja) 1999-05-10
IL92054A0 (en) 1990-07-12
CA1337351C (en) 1995-10-17
PH27278A (en) 1993-05-04
PT92025B (pt) 1995-07-18
DK519189A (da) 1990-04-21
DK170702B1 (da) 1995-12-11
HU206211B (en) 1992-09-28
HUT52775A (en) 1990-08-28
JPH02164880A (ja) 1990-06-25
KR0143998B1 (ko) 1998-07-15
HU895335D0 (en) 1990-01-28
KR900006334A (ko) 1990-05-07
PT92025A (pt) 1990-04-30
DK519189D0 (da) 1989-10-19

Similar Documents

Publication Publication Date Title
IL92054A (en) Spiro-isoquinoline-pyrrolidine tetra and their analogues, their preparations and pharmaceutical preparations containing them
EP0365324B1 (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5045544A (en) N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
CA2093793C (en) Alkylidene analogs of 1'-aminospiro¬isoquinoline-4(1h),-3'-pyrrolidine|1,2',3,5'(2h)-tetrones useful as aldose reductase inhibitors
US5130425A (en) Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
CA2093794C (en) 1'-aminospiro¬isoquinoline-4(1h),3-pyrrolidine|-1,2',3,5'-(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors
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IE913604A1 (en) 1'-aminospiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'¹(2h)-tetrones and analogs thereof useful as aldose reductase¹inhibitors
EP0618917B1 (en) 1'-amino-2- (benzothiazolyl)methyl]spiro isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors
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Legal Events

Date Code Title Description
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees