IL89938A0 - Viper venom polypeptides,their purification and genetic expression - Google Patents

Viper venom polypeptides,their purification and genetic expression

Info

Publication number
IL89938A0
IL89938A0 IL89938A IL8993889A IL89938A0 IL 89938 A0 IL89938 A0 IL 89938A0 IL 89938 A IL89938 A IL 89938A IL 8993889 A IL8993889 A IL 8993889A IL 89938 A0 IL89938 A0 IL 89938A0
Authority
IL
Israel
Prior art keywords
amino acid
purification
polypeptides
genetic expression
viper venom
Prior art date
Application number
IL89938A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL89938A0 publication Critical patent/IL89938A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL89938A 1988-04-22 1989-04-13 Viper venom polypeptides,their purification and genetic expression IL89938A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18464988A 1988-04-22 1988-04-22
US18465388A 1988-04-22 1988-04-22
US30375789A 1989-02-01 1989-02-01

Publications (1)

Publication Number Publication Date
IL89938A0 true IL89938A0 (en) 1989-12-15

Family

ID=27391870

Family Applications (1)

Application Number Title Priority Date Filing Date
IL89938A IL89938A0 (en) 1988-04-22 1989-04-13 Viper venom polypeptides,their purification and genetic expression

Country Status (14)

Country Link
EP (1) EP0338634B1 (ko)
JP (1) JPH02138298A (ko)
KR (1) KR900016261A (ko)
CN (1) CN1039441A (ko)
AT (1) ATE103931T1 (ko)
AU (1) AU627724B2 (ko)
DE (1) DE68914316T2 (ko)
DK (1) DK192189A (ko)
ES (1) ES2063113T3 (ko)
FI (1) FI891916A (ko)
IL (1) IL89938A0 (ko)
NO (1) NO891662L (ko)
NZ (1) NZ228710A (ko)
PT (1) PT90321B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
CA2009613A1 (en) * 1989-02-09 1990-08-09 Victor M. Garsky Polypeptide synthesis
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
WO1991011458A1 (en) * 1990-02-02 1991-08-08 Genentech, Inc. CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
US5227469A (en) * 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
JPH05509294A (ja) * 1990-04-06 1993-12-22 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 血栓症治療のための方法および組成物
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
CA2106314A1 (en) * 1991-04-05 1992-10-06 John P. Burnier Platelet aggregation inhibitors having high specification for gpiibiiia
US5380646A (en) * 1992-10-19 1995-01-10 Temple University Of The Commonwealth System Of Higher Education Thrombus detection using radiolabelled disintegrins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
EP0317053B1 (en) * 1987-11-18 1993-12-08 Temple University of the Commonwealth System of Higher Education Trigramin- a platelet aggregation inhibiting polypeptide

Also Published As

Publication number Publication date
ATE103931T1 (de) 1994-04-15
NZ228710A (en) 1992-10-28
DK192189D0 (da) 1989-04-20
ES2063113T3 (es) 1995-01-01
EP0338634A2 (en) 1989-10-25
EP0338634A3 (en) 1991-05-29
DK192189A (da) 1989-10-23
DE68914316T2 (de) 1994-09-08
AU3329989A (en) 1990-02-15
EP0338634B1 (en) 1994-04-06
FI891916A0 (fi) 1989-04-21
PT90321A (pt) 1989-11-10
NO891662L (no) 1989-10-23
DE68914316D1 (de) 1994-05-11
CN1039441A (zh) 1990-02-07
FI891916A (fi) 1989-10-23
AU627724B2 (en) 1992-09-03
KR900016261A (ko) 1990-11-13
NO891662D0 (no) 1989-04-21
PT90321B (pt) 1994-08-31
JPH02138298A (ja) 1990-05-28

Similar Documents

Publication Publication Date Title
IL89938A0 (en) Viper venom polypeptides,their purification and genetic expression
CA2263889A1 (en) P-selectin ligand proteins
CA2265976A1 (en) High level expression of proteins
ES2018901A6 (es) Metodo para producir y purificar ubiquitin-hidrolasa, asi como para disociar conjugados de ubiquitina-polipeptido.
DK1396542T3 (da) P-selectin ligand protein
HUT46061A (en) Dna sequences encoding hirudin-like protein and process for producing such proteins
CA2087271A1 (en) Superior thrombomodulin analogs for pharmaceutical use
GR3023593T3 (en) Protein structure of the plant toxin gelonin
WO1995030001A3 (en) Novel p-selectin ligand protein
HUT50195A (en) New peptites hindering the activity of immune system and medical compositions containing them and process for production of these peptides and compositions
IL86058A0 (en) Production of proteins
CA2163081A1 (en) Thermoresistant Alpha-1-Antitrypsin Mutein
ATE109827T1 (de) Verfahren zur herstellung von peptiden, dazu zu verwendendes rekombinantes plasmid und mit diesem plasmid transformierte myelomzellen.
EP0723016A3 (en) Leukocyte activation factor
EP0613946A3 (en) Hst-2 mutein, dna coding for the same and preparation thereof.
WO1999043834A3 (en) P-selectin ligand protein, including tetrameric fusion proteins