IL88197A0 - Sustained release delivery system for substituted dihydropyridine calcium channel blockers - Google Patents

Sustained release delivery system for substituted dihydropyridine calcium channel blockers

Info

Publication number
IL88197A0
IL88197A0 IL88197A IL8819788A IL88197A0 IL 88197 A0 IL88197 A0 IL 88197A0 IL 88197 A IL88197 A IL 88197A IL 8819788 A IL8819788 A IL 8819788A IL 88197 A0 IL88197 A0 IL 88197A0
Authority
IL
Israel
Prior art keywords
delivery system
sustained release
calcium channel
channel blockers
release delivery
Prior art date
Application number
IL88197A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL88197A0 publication Critical patent/IL88197A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
IL88197A 1987-11-25 1988-10-28 Sustained release delivery system for substituted dihydropyridine calcium channel blockers IL88197A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12544087A 1987-11-25 1987-11-25

Publications (1)

Publication Number Publication Date
IL88197A0 true IL88197A0 (en) 1989-06-30

Family

ID=22419737

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88197A IL88197A0 (en) 1987-11-25 1988-10-28 Sustained release delivery system for substituted dihydropyridine calcium channel blockers

Country Status (15)

Country Link
EP (1) EP0317780B1 (xx)
JP (1) JPH02655A (xx)
KR (1) KR890007746A (xx)
AT (1) ATE76292T1 (xx)
AU (1) AU626187B2 (xx)
DE (1) DE3871343D1 (xx)
DK (1) DK656488A (xx)
ES (1) ES2037179T3 (xx)
FI (1) FI885454A (xx)
GR (1) GR3004988T3 (xx)
IL (1) IL88197A0 (xx)
NO (1) NO885246L (xx)
NZ (1) NZ226987A (xx)
PT (1) PT89055A (xx)
ZA (1) ZA888817B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117784A1 (de) * 1991-05-31 1992-12-03 Basf Ag Herstellung von protein-polyalkylenglykolkonjugaten
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
ATE151090T1 (de) * 1993-06-29 1997-04-15 Heylecina Societe Anonyme Herstellung von aktivierten carbamaten von polyalkylenglycol und ihre verwendung
IE80467B1 (en) * 1995-07-03 1998-07-29 Elan Corp Plc Controlled release formulations for poorly soluble drugs
EP0951279A1 (en) * 1997-01-10 1999-10-27 Abbott Laboratories Tablet for the controlled release of active agents
US6013280A (en) * 1997-10-07 2000-01-11 Fuisz Technologies Ltd. Immediate release dosage forms containing microspheres
SE9704401D0 (sv) * 1997-11-28 1997-11-28 Astra Ab Matrix pellets for greasy, oily or sticky drug substances
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
DK1429126T3 (da) 2002-12-09 2013-03-11 Ishida Seisakusho Kombinationsvægt
DK1628663T3 (da) 2003-05-15 2010-03-08 Roskamp Res Llc Fremgangsmåde til fremstilling af medikamenter til reduktion af amyloid-aflejring, amyloid-neurotoksicitet og mikrogliose
CA2561733A1 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
EP1828099B1 (en) 2004-11-18 2020-01-22 Correvio International Sàrl Synthetic process for aminocyclohexyl ether compounds
CA2612375C (en) 2005-06-15 2013-08-06 Cardiome Pharma Corp. Synthetic processes for the preparation of aminocyclohexyl ether compounds
DK2214666T3 (da) 2007-10-05 2014-01-27 Alzheimer S Inst Of America Inc Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA959759A (en) * 1970-01-15 1974-12-24 John J. Miskel Method for absorption of drugs
FR2518403B1 (fr) * 1981-12-22 1987-01-02 Dietlin Francois Procede de preparation de formes pharmaceutiques presentant une resorption par voie digestive amelioree, et les formes pharmaceutiques ainsi obtenues
IT1174779B (it) * 1982-09-27 1987-07-01 Sandoz Ag L'impiego in terapeutica dei derivati della 1,4-di idropiridina
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device

Also Published As

Publication number Publication date
KR890007746A (ko) 1989-07-05
NO885246L (no) 1989-05-26
DK656488A (da) 1989-05-26
EP0317780A1 (en) 1989-05-31
NO885246D0 (no) 1988-11-24
DE3871343D1 (de) 1992-06-25
PT89055A (pt) 1989-11-30
ES2037179T3 (es) 1993-06-16
EP0317780B1 (en) 1992-05-20
NZ226987A (en) 1992-04-28
DK656488D0 (da) 1988-11-24
AU2587088A (en) 1989-05-25
FI885454A0 (fi) 1988-11-24
ATE76292T1 (de) 1992-06-15
FI885454A (fi) 1989-05-26
GR3004988T3 (xx) 1993-04-28
AU626187B2 (en) 1992-07-23
JPH02655A (ja) 1990-01-05
ZA888817B (en) 1989-08-30

Similar Documents

Publication Publication Date Title
IL88197A0 (en) Sustained release delivery system for substituted dihydropyridine calcium channel blockers
ES2061609T3 (es) 2',3'-dideoxi-2'-fluoro-nucleosidos.
DE3888530D1 (de) 3'-Azido-2',3'-dideoxynucleosid-5'-phosphonate.
ITMI913465A1 (it) Procedimento per la depurazione dell'1, 1, 1-trifluoro-2-fluoroetano
GR870824B (en) Process for the preparation of new 1,4 - dihydropyridines useful as antithrombotic drugs
GR3004863T3 (xx)
TW245740B (xx)
ES2038665T3 (es) Procedimiento de sintesis de penems.
SE8700361D0 (sv) Immunosuppressant agents
NZ229300A (en) Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
ATE90098T1 (de) Cycloalkan(1,2-c:4,3-c'>dipyrazole.
NO904533D0 (no) Fremgangsmaate for molekylvektsregulering av polydiklorfosfasener.
IT8721895A0 (it) Policarbonati resistenti alla fiamma, contenenti nella catena polimerica unita' derivanti da composti tetrafenilici monoalogenati.
AU3644289A (en) Novel derivatives, process for their preparation, intermediates and their use as medicaments
YU119788A (en) Process for producing calcium 10-propyl-2,8-bis (1h-tetrazol-5-yl)-4h,6h-benzo (1,2-6,5,4-b')
IT217687Z2 (it) Struttura di calzatura, particolarmente per l'arrampicata libera.
IT8921095A0 (it) Composizione per l'aumento del guadagno di peso.
IT8719368A0 (it) Composizione solida, resistente all'idrolisi, stabilizzante per i polimeri organici e procedimento per la sua preparazione.
GB8910205D0 (en) 2,6-dimethyl-1,4-dihydrophyridine-3,5-dicarboxylic acid adamentyl esters
NO884264D0 (no) 3'-azido-2',3'-dideoksyuridin-anti-retrovirus-blanding.
EP0537591A3 (en) Process for the preparation of 1,2-bis-(2-nitrophenoxy)-ethane
IE880214L (en) 3'-azido-2',3'-dideoxyuridine anti-retroviral compositions