IL86102A - Alkylated peptides that release growth hormone and their use - Google Patents
Alkylated peptides that release growth hormone and their useInfo
- Publication number
- IL86102A IL86102A IL8610288A IL8610288A IL86102A IL 86102 A IL86102 A IL 86102A IL 8610288 A IL8610288 A IL 8610288A IL 8610288 A IL8610288 A IL 8610288A IL 86102 A IL86102 A IL 86102A
- Authority
- IL
- Israel
- Prior art keywords
- peptide
- ser
- asn
- arg
- gly
- Prior art date
Links
- 102100033367 Appetite-regulating hormone Human genes 0.000 title description 2
- 101710119601 Growth hormone-releasing peptides Proteins 0.000 title description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 41
- 239000002253 acid Substances 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- -1 methyl naphthyl Chemical group 0.000 claims description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
- 102000018997 Growth Hormone Human genes 0.000 claims description 6
- 108010051696 Growth Hormone Proteins 0.000 claims description 6
- 239000000122 growth hormone Substances 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000000524 functional group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
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- 108010091748 peptide A Proteins 0.000 claims 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- BBNAWOUKGXTSRB-QGUOKLOCSA-N (2S,3S)-2-amino-3-methylpentanoic acid (2S)-2-aminopentanedioic acid (2S)-2,6-diaminohexanoic acid Chemical compound CC[C@H](C)[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O BBNAWOUKGXTSRB-QGUOKLOCSA-N 0.000 description 1
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- CONKBQPVFMXDOV-QHCPKHFHSA-N 6-[(5S)-5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-2-oxo-1,3-oxazolidin-3-yl]-3H-1,3-benzoxazol-2-one Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C[C@H]1CN(C(O1)=O)C1=CC2=C(NC(O2)=O)C=C1 CONKBQPVFMXDOV-QHCPKHFHSA-N 0.000 description 1
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- 125000001931 aliphatic group Chemical group 0.000 description 1
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- 150000003973 alkyl amines Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
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- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
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- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
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- 239000001307 helium Substances 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- WXEHBUMAEPOYKP-UHFFFAOYSA-N methylsulfanylethane Chemical compound CCSC WXEHBUMAEPOYKP-UHFFFAOYSA-N 0.000 description 1
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
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- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- WPPDXAHGCGPUPK-UHFFFAOYSA-N red 2 Chemical compound C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=2C=3C4=CC=C5C6=CC=C7C8=C(C=9C=CC=CC=9)C9=CC=CC=C9C(C=9C=CC=CC=9)=C8C8=CC=C(C6=C87)C(C=35)=CC=2)C4=C1C1=CC=CC=C1 WPPDXAHGCGPUPK-UHFFFAOYSA-N 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 239000011593 sulfur Substances 0.000 description 1
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- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4820387A | 1987-05-11 | 1987-05-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL86102A0 IL86102A0 (en) | 1988-11-15 |
| IL86102A true IL86102A (en) | 1994-04-12 |
Family
ID=21953263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8610288A IL86102A (en) | 1987-05-11 | 1988-04-18 | Alkylated peptides that release growth hormone and their use |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0314866A3 (da) |
| JP (1) | JP2678993B2 (da) |
| KR (1) | KR0136285B1 (da) |
| AU (1) | AU613364B2 (da) |
| DK (1) | DK255688A (da) |
| FI (1) | FI882180A (da) |
| IL (1) | IL86102A (da) |
| NO (1) | NO882034L (da) |
| NZ (1) | NZ224487A (da) |
| PT (1) | PT87419B (da) |
| ZA (1) | ZA883307B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2040649A1 (en) * | 1990-04-24 | 1991-10-25 | Gerald S. Brooke | Growth hormone releasing factor analogs |
| CA2082059A1 (en) * | 1990-05-04 | 1991-11-05 | David H. Coy | Synthetic grf analogs |
| IE912345A1 (en) * | 1990-08-03 | 1992-02-12 | Pharmacia Ab | Treatment of human lactation failure |
| EP0828758B1 (en) * | 1995-05-26 | 2001-08-29 | Theratechnologies Inc. | Chimeric fatty body-pro-grf analogs with increased biological potency |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| US4659693A (en) | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
-
1988
- 1988-04-18 IL IL8610288A patent/IL86102A/en not_active IP Right Cessation
- 1988-05-04 NZ NZ224487A patent/NZ224487A/xx unknown
- 1988-05-05 PT PT87419A patent/PT87419B/pt not_active IP Right Cessation
- 1988-05-09 JP JP63110664A patent/JP2678993B2/ja not_active Expired - Lifetime
- 1988-05-10 KR KR88005479A patent/KR0136285B1/ko not_active IP Right Cessation
- 1988-05-10 AU AU15898/88A patent/AU613364B2/en not_active Ceased
- 1988-05-10 DK DK255688A patent/DK255688A/da not_active Application Discontinuation
- 1988-05-10 NO NO882034A patent/NO882034L/no unknown
- 1988-05-10 ZA ZA883307A patent/ZA883307B/xx unknown
- 1988-05-10 FI FI882180A patent/FI882180A/fi not_active Application Discontinuation
- 1988-05-11 EP EP88107630A patent/EP0314866A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NZ224487A (en) | 1991-11-26 |
| DK255688D0 (da) | 1988-05-10 |
| FI882180A0 (fi) | 1988-05-10 |
| KR0136285B1 (en) | 1998-04-25 |
| IL86102A0 (en) | 1988-11-15 |
| PT87419A (pt) | 1989-05-31 |
| FI882180A (fi) | 1988-11-12 |
| JP2678993B2 (ja) | 1997-11-19 |
| AU613364B2 (en) | 1991-08-01 |
| PT87419B (pt) | 1993-02-26 |
| EP0314866A2 (en) | 1989-05-10 |
| KR880013970A (ko) | 1988-12-22 |
| JPS63287799A (ja) | 1988-11-24 |
| NO882034L (no) | 1988-11-14 |
| DK255688A (da) | 1988-11-12 |
| ZA883307B (en) | 1988-11-14 |
| AU1589888A (en) | 1988-11-17 |
| EP0314866A3 (en) | 1990-07-18 |
| NO882034D0 (no) | 1988-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |