IL85884A - Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides - Google Patents

Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides

Info

Publication number
IL85884A
IL85884A IL85884A IL8588488A IL85884A IL 85884 A IL85884 A IL 85884A IL 85884 A IL85884 A IL 85884A IL 8588488 A IL8588488 A IL 8588488A IL 85884 A IL85884 A IL 85884A
Authority
IL
Israel
Prior art keywords
support
synthesis
peptides
synthetic resin
manufacture
Prior art date
Application number
IL85884A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of IL85884A publication Critical patent/IL85884A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/50—Partial depolymerisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Glass Compositions (AREA)
  • Polyamides (AREA)
  • Working-Up Tar And Pitch (AREA)
  • Paper (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
IL85884A 1987-03-30 1988-03-28 Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides IL85884A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH121487 1987-03-30

Publications (1)

Publication Number Publication Date
IL85884A true IL85884A (en) 1992-01-15

Family

ID=4205167

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85884A IL85884A (en) 1987-03-30 1988-03-28 Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides

Country Status (19)

Country Link
US (3) US4859736A (fi)
EP (1) EP0285562B1 (fi)
JP (1) JP2513775B2 (fi)
KR (1) KR950013679B1 (fi)
AT (1) ATE88726T1 (fi)
AU (1) AU615181B2 (fi)
CA (1) CA1318462C (fi)
DD (3) DD274033A5 (fi)
DE (1) DE3880541D1 (fi)
DK (1) DK175042B1 (fi)
ES (1) ES2054863T3 (fi)
FI (1) FI90780C (fi)
GR (1) GR3007996T3 (fi)
HU (1) HU208155B (fi)
IE (1) IE61485B1 (fi)
IL (1) IL85884A (fi)
MX (1) MX10917A (fi)
PT (1) PT87105B (fi)
YU (1) YU62588A (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
US5242974A (en) * 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5212288A (en) * 1990-02-20 1993-05-18 Syntex (U.S.A.) Inc. Temporary minimal protection synthesis of serine-containing polypeptides
US5155166A (en) * 1990-06-18 1992-10-13 Eastman Kodak Company Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same
US5071565A (en) * 1991-02-04 1991-12-10 Iowa State University Research Foundation, Inc. Modified resins for solid-phase extraction
US5550215A (en) * 1991-11-22 1996-08-27 Holmes; Christopher P. Polymer reversal on solid surfaces
US5268423A (en) * 1992-02-28 1993-12-07 New York University Method for preparation of peptide synthesis resins and peptide synthesis resins
US5516891A (en) * 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
IE921942A1 (en) * 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
CA2269669A1 (en) 1996-11-04 1998-05-14 3-Dimensional Pharmaceuticals, Inc. System, method and computer program product for identifying chemical compounds having desired properties
US6392010B1 (en) 1996-12-19 2002-05-21 Aventis Pharmaceuticals Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
GB9717173D0 (en) * 1997-08-13 1997-10-22 Akzo Nobel Nv Solid phase supports
US6114468A (en) * 1998-06-01 2000-09-05 Novartis Ag Synthetic resins for use in solid phase synthesis
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
AU2001247627A1 (en) 2000-03-22 2001-10-03 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
CA2419600A1 (en) * 2000-08-22 2002-02-28 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
US6678619B2 (en) * 2000-09-20 2004-01-13 Victor S. Lobanov Method, system, and computer program product for encoding and building products of a virtual combinatorial library
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
WO2002083606A1 (en) * 2001-04-17 2002-10-24 University Of Alberta A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
DE60304184T2 (de) * 2002-01-25 2006-12-28 Phenomenex, Inc., Torrance Oberflächenpfropfmodifizierte harze und deren herstellung
US6926823B2 (en) * 2002-06-03 2005-08-09 Varian, Inc. Polymer with superior polar retention for sample pretreatment
JP4579240B2 (ja) * 2003-07-04 2010-11-10 ロンザ アーゲー 担持相合成法の改善
EP1630600A3 (en) * 2004-07-29 2006-03-22 Rohm and Haas Electronic Materials, L.L.C. Hot melt composition and method involving forming a masking pattern
WO2006060803A2 (en) * 2004-12-03 2006-06-08 Polnox Corporation One pot process for making polymeric antioxidants
WO2010129520A1 (en) * 2009-05-06 2010-11-11 Mallinckrodt Inc. Solid support for fmoc-solid phase synthesis of peptide acids
TWI787670B (zh) 2011-12-28 2022-12-21 日商中外製藥股份有限公司 具有環狀部之胜肽化合物及其醫藥組成物
WO2015077635A2 (en) 2013-11-22 2015-05-28 Polnox Corporation Macromolecular antioxidants based on dual type moiety per molecule: structures methods of making and using the same
DK3269809T3 (da) 2015-03-13 2022-09-12 Chugai Pharmaceutical Co Ltd MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF
US12391971B2 (en) 2017-01-31 2025-08-19 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptides in cell-free translation system
US20180251695A1 (en) 2017-03-01 2018-09-06 Polnox Corporation Macromolecular Corrosion (McIn) Inhibitors: Structures, Methods Of Making And Using The Same
WO2018225851A1 (ja) 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
EP3725796A4 (en) * 2017-12-15 2021-09-15 Chugai Seiyaku Kabushiki Kaisha METHOD FOR MANUFACTURING PEPTIDE AND METHOD FOR PROCESSING BASES
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
JP7568510B2 (ja) 2018-11-30 2024-10-16 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
KR20210139366A (ko) 2019-03-15 2021-11-22 추가이 세이야쿠 가부시키가이샤 방향족 아미노산 유도체의 제조 방법
PE20221323A1 (es) 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd Compuesto de peptidos ciclicos que tiene accion inhibidora de kras
CN119912618B (zh) * 2023-10-31 2025-11-18 北京索特莱克科技发展有限公司 提锂树脂的结构、制备和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE141977C (fi) *
GB1406611A (en) * 1971-08-17 1975-09-17 Leo Ab Pharmaceutically active secondary phosphoric acid esters
DD141977A3 (de) * 1975-07-11 1980-06-04 Jens Fischer Verfahren zur herstellung wasserunloeslicher enzym-polystyrol-komplexe
US4301045A (en) * 1977-05-02 1981-11-17 Armour Pharmaceutical Company Synthesis of peptides
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4569967A (en) * 1983-10-24 1986-02-11 The Salk Institute For Biological Studies Synthesis of N-substituted peptide amides
US4623484A (en) * 1984-05-24 1986-11-18 Research Corporation Process for peptide synthesis
GB2169901A (en) * 1984-12-11 1986-07-23 Lkb Biochrom Ltd method for a solid phase synthesis of a linear combination of amino acid residues.
US4731412A (en) * 1984-12-28 1988-03-15 The Salk Institute Biotechnology/Industrial Associates, Inc. Process and composition for amino-terminal, α-aspartyl and α-glutamyl dipeptide esters
US4716147A (en) * 1986-03-27 1987-12-29 Monsanto Company Synthetic airial peptides
CA1329124C (en) * 1987-02-02 1994-05-03 Jerald C. Sadoff Conjugate malaria vaccine
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis

Also Published As

Publication number Publication date
ES2054863T3 (es) 1994-08-16
US5093530A (en) 1992-03-03
EP0285562A2 (de) 1988-10-05
KR880011210A (ko) 1988-10-27
FI90780B (fi) 1993-12-15
DK173088D0 (da) 1988-03-29
US4859736A (en) 1989-08-22
JP2513775B2 (ja) 1996-07-03
DD296087A5 (de) 1991-11-21
HU208155B (en) 1993-08-30
EP0285562B1 (de) 1993-04-28
FI881451A7 (fi) 1988-10-01
KR950013679B1 (ko) 1995-11-13
DK173088A (da) 1988-10-01
GR3007996T3 (fi) 1993-08-31
US5004781A (en) 1991-04-02
HUT46713A (en) 1988-11-28
MX10917A (es) 1993-12-01
PT87105B (pt) 1992-07-31
AU615181B2 (en) 1991-09-26
DE3880541D1 (de) 1993-06-03
PT87105A (pt) 1988-04-01
CA1318462C (en) 1993-05-25
IE880940L (en) 1988-09-30
FI90780C (fi) 1994-03-25
ATE88726T1 (de) 1993-05-15
DK175042B1 (da) 2004-05-10
JPS63260946A (ja) 1988-10-27
DD274033A5 (de) 1989-12-06
IE61485B1 (en) 1994-11-02
DD284031A5 (de) 1990-10-31
AU1381488A (en) 1988-09-29
YU62588A (en) 1990-10-31
EP0285562A3 (en) 1990-01-10
FI881451A0 (fi) 1988-03-28

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Legal Events

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