IL84928A - Preparations and methods for synthesis and encaplase testing - Google Patents

Preparations and methods for synthesis and encaplase testing

Info

Publication number
IL84928A
IL84928A IL8492887A IL8492887A IL84928A IL 84928 A IL84928 A IL 84928A IL 8492887 A IL8492887 A IL 8492887A IL 8492887 A IL8492887 A IL 8492887A IL 84928 A IL84928 A IL 84928A
Authority
IL
Israel
Prior art keywords
enkephalinase
gly
dna
sequence
dansyl
Prior art date
Application number
IL8492887A
Other languages
English (en)
Hebrew (he)
Other versions
IL84928A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL84928A0 publication Critical patent/IL84928A0/xx
Publication of IL84928A publication Critical patent/IL84928A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL8492887A 1986-12-24 1987-12-23 Preparations and methods for synthesis and encaplase testing IL84928A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94656686A 1986-12-24 1986-12-24
US07/002,478 US4960700A (en) 1986-12-24 1987-01-12 Compositions and methods for the synthesis and assay of a mammalian enkephalinase

Publications (2)

Publication Number Publication Date
IL84928A0 IL84928A0 (en) 1988-06-30
IL84928A true IL84928A (en) 1994-02-27

Family

ID=26670440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8492887A IL84928A (en) 1986-12-24 1987-12-23 Preparations and methods for synthesis and encaplase testing

Country Status (11)

Country Link
US (2) US4960700A (de)
EP (2) EP0272928B1 (de)
JP (1) JP2685468B2 (de)
AT (1) ATE119936T1 (de)
AU (1) AU623845B2 (de)
DE (1) DE3751169T2 (de)
DK (1) DK684087A (de)
ES (1) ES2072251T3 (de)
IE (1) IE66333B1 (de)
IL (1) IL84928A (de)
NZ (1) NZ223028A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272929B1 (de) * 1986-12-24 1996-03-20 Genentech, Inc. Enkephalinase für therapeutische Verwendung
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
US6372438B1 (en) * 1988-02-02 2002-04-16 The Regents Of The University Of California Human platelet-derived growth factor receptors
US5486599A (en) * 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US5541083A (en) * 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
FR2664287A1 (fr) * 1990-07-03 1992-01-10 Inst Nat Sante Rech Med Nouveau polypeptide presentant une activite enzymatique, et gene codant pour ce polypeptide.
IL99465A (en) * 1990-09-14 2001-04-30 Hoechst Ag Process for the chemical synthesis of oligonucleotides and a number of new intermediates - 5 Denzyl ethoxycarbonyl oligonucleotides
AU671417B2 (en) * 1991-03-15 1996-08-29 Merck Serono Sa Human follicle stimulating hormone receptor
US6048975A (en) * 1991-09-12 2000-04-11 Hoechst Aktiengesellschaft Process for the chemical synthesis of oligonucleotides
AU5457294A (en) * 1992-10-29 1994-05-24 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
WO1994012209A1 (en) * 1992-12-02 1994-06-09 Dana-Farber Cancer Institute, Inc. Malignant cell growth regulation by common acute lymphoblastic leukemia antigen
US5807711A (en) * 1993-03-23 1998-09-15 Taisho Pharmaceutical Co., Ltd. Parenchymal hepatocyte growth factors
JP4043535B2 (ja) * 1994-06-21 2008-02-06 サントリー株式会社 ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法
GB9525403D0 (en) * 1995-12-13 1996-02-14 Univ Sunderland Method for monitoring enzymes
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
FR2777291B1 (fr) * 1998-04-08 2000-07-07 Inst Nat Sante Rech Med Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
EP1069188A1 (de) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Neprilysin-ähnliche Membran-Metallopeptidasen,
CN1250717C (zh) * 1999-11-19 2006-04-12 索尔瓦药物有限公司 金属蛋白酶家族中的人酶
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
CA2450316A1 (en) * 2001-06-11 2002-12-19 Medarex, Inc. Cd10-activated prodrug compounds
WO2005123119A2 (en) * 2004-06-10 2005-12-29 Catalyst Biosciences, Inc. Administration of neutral endopeptidase to treat inflammatory bowel disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5262178A (en) * 1987-01-12 1993-11-16 Genentech, Inc. Therapeutic use of enkephalinase

Also Published As

Publication number Publication date
DK684087D0 (da) 1987-12-23
JP2685468B2 (ja) 1997-12-03
AU623845B2 (en) 1992-05-28
EP0272928A3 (en) 1990-04-04
EP0272928A2 (de) 1988-06-29
JPH01104178A (ja) 1989-04-21
AU8305887A (en) 1988-06-30
IE873535L (en) 1988-06-24
EP0596355A1 (de) 1994-05-11
IL84928A0 (en) 1988-06-30
US5780025A (en) 1998-07-14
NZ223028A (en) 1990-09-26
ES2072251T3 (es) 1995-07-16
IE66333B1 (en) 1995-12-27
DE3751169T2 (de) 1995-10-26
DE3751169D1 (de) 1995-04-20
ATE119936T1 (de) 1995-04-15
DK684087A (da) 1988-10-03
US4960700A (en) 1990-10-02
EP0272928B1 (de) 1995-03-15

Similar Documents

Publication Publication Date Title
US5780025A (en) Compositions and methods for the synthesis and assay of enkephalinase
EP0278776B2 (de) Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein
Wesselschmidt et al. Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa
JP3149185B2 (ja) エンテロキナーゼのクローニングおよび使用方法
CA1341485C (en) Fusion proteins utilizing the decay accelerating factor membrane binding domain
JP4748908B2 (ja) ジペプチジルペプチダーゼ
KR20110114587A (ko) 세린 프로테아제 유도체 및 혈액응고 장애의 치료 또는 예방의 용도
NZ526616A (en) Von willebrand factor (vWF) cleaving protease polypeptide, nucleic acid encoding the polypeptide and use of polypeptide in treating thrombosis disorders
GB2246779A (en) Antitumour molecules.
US20080234191A1 (en) Human complement C3 derivates with cobra venom factor-like function
US6086871A (en) Prothrombin derivatives
US6746859B1 (en) Cloning of enterokinase and method of use
CA2199719A1 (en) Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin
US7335758B2 (en) Catalytic domain of ADAM33 and methods of use thereof
US5264357A (en) Nucleic acids vectors and cells for the synthesis of membrane anchor fusion polypeptides
US7084251B1 (en) Methods and Deoxyribonucleic acid for the preparation of tissue factor protein
US7049131B1 (en) Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US6994988B1 (en) Methods and deoxyribonucleic acid for the preparation of tissue factor protein
CA1341589C (en) Methods and deoxyribonucleic acid for the preparation of tissue factor protein
WO2001021205A1 (en) Coupling factor 6 inhibitor and potentiator and use thereof
Isordia-Salas et al. The Mutation S 511 N Leads to N-glycosylation and Increases the Cleavage of High Molecular Weight Kininogen In Rats Genetically Susceptible to Inflammation
JPWO2003066089A1 (ja) メグシンリガンド

Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees