IL84765A - 9-(1-carboxy-3-(guanidinophenyl)propylamino)octahydro-10-oxo-6h-pyridazo(1,2-a)-(1,2)diazepine-1-carboxylic acids and esters,their preparation and pharmaceutical compositions containing them and some intermediates therefor - Google Patents
9-(1-carboxy-3-(guanidinophenyl)propylamino)octahydro-10-oxo-6h-pyridazo(1,2-a)-(1,2)diazepine-1-carboxylic acids and esters,their preparation and pharmaceutical compositions containing them and some intermediates thereforInfo
- Publication number
- IL84765A IL84765A IL84765A IL8476587A IL84765A IL 84765 A IL84765 A IL 84765A IL 84765 A IL84765 A IL 84765A IL 8476587 A IL8476587 A IL 8476587A IL 84765 A IL84765 A IL 84765A
- Authority
- IL
- Israel
- Prior art keywords
- pyridazo
- guanidinophenyl
- diazepine
- octahydro
- propylamino
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868629875A GB8629875D0 (en) | 1986-12-15 | 1986-12-15 | Pyridazodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL84765A0 IL84765A0 (en) | 1988-05-31 |
| IL84765A true IL84765A (en) | 1991-06-30 |
Family
ID=10609005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL84765A IL84765A (en) | 1986-12-15 | 1987-12-09 | 9-(1-carboxy-3-(guanidinophenyl)propylamino)octahydro-10-oxo-6h-pyridazo(1,2-a)-(1,2)diazepine-1-carboxylic acids and esters,their preparation and pharmaceutical compositions containing them and some intermediates therefor |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4757069A (sv) |
| EP (1) | EP0271795A3 (sv) |
| JP (1) | JPS63162693A (sv) |
| KR (1) | KR880007538A (sv) |
| AU (1) | AU602546B2 (sv) |
| CA (1) | CA1291478C (sv) |
| DK (1) | DK628087A (sv) |
| FI (1) | FI85482C (sv) |
| GB (1) | GB8629875D0 (sv) |
| HU (1) | HU198492B (sv) |
| IL (1) | IL84765A (sv) |
| MC (1) | MC1879A1 (sv) |
| NO (1) | NO166083C (sv) |
| NZ (1) | NZ222825A (sv) |
| PH (1) | PH23813A (sv) |
| PT (1) | PT86365B (sv) |
| ZA (1) | ZA879229B (sv) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| ES2106112T3 (es) * | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
| ES2117123T3 (es) * | 1992-02-14 | 1998-08-01 | Merrell Pharma Inc | Derivados de aminocetilmercaptoacetilamida utilizados como inhibidores de la encefalinasa y del enzima de conversion de angiotensina. |
| NZ251930A (en) * | 1992-05-15 | 1996-02-27 | Merrell Dow Pharma | Mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a]diazepine and pyrazolo[1,2-a]diazepine derivatives, pharmaceutical compositions and preparatory methods |
| US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| DE69329701T2 (de) * | 1992-10-30 | 2001-05-10 | Merrell Pharma Inc | Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer |
| JPH09508906A (ja) * | 1994-02-14 | 1997-09-09 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類 |
| HUT74584A (en) * | 1994-02-14 | 1997-01-28 | Merrell Pharma Inc | Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them |
| EP0746566A1 (en) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| JP3596778B2 (ja) * | 1994-02-14 | 2004-12-02 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類 |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| HUT75160A (en) * | 1994-03-24 | 1997-04-28 | Merrell Pharma Inc | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
| CN1144482A (zh) * | 1994-03-24 | 1997-03-05 | 默里尔药物公司 | 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物 |
| WO2001060879A1 (fr) * | 2000-02-17 | 2001-08-23 | China Petroleum & Chemical Corporation | Copolymere multisequence et son procede de preparation |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| IE20070935A1 (en) * | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Guanidine based compounds and their use in the treatment of mental and neurological disorders. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4092438A (en) * | 1977-04-29 | 1978-05-30 | Carnation Company | Non-dairy coffee whitener containing acetate salt |
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| GB8320764D0 (en) * | 1983-08-02 | 1983-09-01 | Rhodes Joseph Ltd | Bending machines |
| US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
| EP0187037A3 (en) * | 1984-12-21 | 1988-03-23 | Takeda Chemical Industries, Ltd. | Piperidine derivatives, their production and use |
-
1986
- 1986-12-15 GB GB868629875A patent/GB8629875D0/en active Pending
-
1987
- 1987-11-24 US US07/124,749 patent/US4757069A/en not_active Expired - Fee Related
- 1987-11-30 DK DK628087A patent/DK628087A/da not_active Application Discontinuation
- 1987-12-07 NZ NZ222825A patent/NZ222825A/en unknown
- 1987-12-07 EP EP87118047A patent/EP0271795A3/de not_active Ceased
- 1987-12-08 ZA ZA879229A patent/ZA879229B/xx unknown
- 1987-12-08 CA CA000553720A patent/CA1291478C/en not_active Expired - Fee Related
- 1987-12-09 AU AU82254/87A patent/AU602546B2/en not_active Ceased
- 1987-12-09 IL IL84765A patent/IL84765A/xx unknown
- 1987-12-10 MC MC871934A patent/MC1879A1/xx unknown
- 1987-12-11 HU HU875592A patent/HU198492B/hu unknown
- 1987-12-14 KR KR870014258A patent/KR880007538A/ko not_active Application Discontinuation
- 1987-12-14 NO NO875200A patent/NO166083C/no unknown
- 1987-12-14 JP JP62314308A patent/JPS63162693A/ja active Pending
- 1987-12-14 FI FI875483A patent/FI85482C/sv not_active IP Right Cessation
- 1987-12-14 PH PH36217A patent/PH23813A/en unknown
- 1987-12-15 PT PT86365A patent/PT86365B/pt not_active IP Right Cessation
-
1988
- 1988-03-17 US US07/169,266 patent/US4782149A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4757069A (en) | 1988-07-12 |
| EP0271795A2 (de) | 1988-06-22 |
| ZA879229B (en) | 1988-06-15 |
| JPS63162693A (ja) | 1988-07-06 |
| GB8629875D0 (en) | 1987-01-28 |
| KR880007538A (ko) | 1988-08-27 |
| NO166083C (no) | 1991-05-29 |
| FI875483A (fi) | 1988-06-16 |
| PT86365A (en) | 1988-01-01 |
| NO875200L (no) | 1988-06-16 |
| NZ222825A (en) | 1990-11-27 |
| DK628087A (da) | 1988-06-16 |
| MC1879A1 (fr) | 1989-01-24 |
| NO166083B (no) | 1991-02-18 |
| FI85482C (sv) | 1992-04-27 |
| FI85482B (fi) | 1992-01-15 |
| NO875200D0 (no) | 1987-12-14 |
| IL84765A0 (en) | 1988-05-31 |
| PT86365B (pt) | 1990-11-20 |
| CA1291478C (en) | 1991-10-29 |
| HU198492B (en) | 1989-10-30 |
| PH23813A (en) | 1989-11-23 |
| FI875483A0 (fi) | 1987-12-14 |
| AU8225487A (en) | 1988-06-16 |
| AU602546B2 (en) | 1990-10-18 |
| HUT47279A (en) | 1989-02-28 |
| EP0271795A3 (de) | 1989-08-09 |
| DK628087D0 (da) | 1987-11-30 |
| US4782149A (en) | 1988-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL84765A (en) | 9-(1-carboxy-3-(guanidinophenyl)propylamino)octahydro-10-oxo-6h-pyridazo(1,2-a)-(1,2)diazepine-1-carboxylic acids and esters,their preparation and pharmaceutical compositions containing them and some intermediates therefor | |
| GB8812273D0 (en) | New cyclosporin analogs with modified"c-9-amino]"acids | |
| IL76133A (en) | Mercaptomethyl-octahydro-oxo-pyridazino(1,2-a)(1,2)diazepine-,diazocine-and(1,2,5)triazepinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them and certain intermediates therefor | |
| IL87079A0 (en) | Tetrahydrocarbazole 1-alkanoic acids and pharmaceutical compositions containing them | |
| CY1703A (en) | Substituted a-amino acids their preparation and pharmaceutical compositions containing them | |
| NZ220365A (en) | Antiviral peptides and pharmaceutical compositions | |
| IL92545A0 (en) | Preparation of 2-chloropyridine-3-carboxylic acid esters | |
| EP0488467A3 (en) | Preparation of alkoxyalkanoic acids | |
| IL87800A0 (en) | Dioxolane-2-carboxylic acids and pharmaceutical compositions comprising them | |
| IL87435A (en) | 6-substituted-imidazo (1,2-b) pyridazin-2-yl carbamate esters, their preparation and pharmaceutical compositions containing them | |
| ZA877444B (en) | Pharmaceutical compositions containing alpha-halogenated dicarboxylic acids | |
| AU608155B2 (en) | Preparation of dicarboxylic acid | |
| ZA822933B (en) | Aminocyclopentanol acids and esters and their preparation and pharmaceutical formulation | |
| IL87185A (en) | Preparation of quinolone- carboxylic acids | |
| GB8717640D0 (en) | Preparation of esters | |
| IL79181A0 (en) | 3-(substituted)propenylaminothiazolylcephalosporanic acids and esters thereof,their preparation and pharmaceutical compositions containing them | |
| IL84724A0 (en) | Substituted aminomethyl-5,6,7,8-tetrahydronaphthyloxyacetic acids and esters and amides thereof,their preparation and pharmaceutical compositions containing them | |
| GB8712909D0 (en) | Preparation of esters | |
| NZ218614A (en) | 16,17-butylidenedioxy-6,9-difluoro-11-hydroxy-3, 20-dioxopregna-1,4-diene-21-oic acid esters and pharmaceutical compositions | |
| IL68830A0 (en) | Preparation of 2,2-dimethyl-3-arylcyclopropanecarboxylic acids and esters thereof and new intermediate-3-butanone derivatives thereof | |
| IL75527A (en) | 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them | |
| GB8602177D0 (en) | Preparation of diester of dicarboxylic acid | |
| IL70651A (en) | 7-(2-arylethenyl)-5-oxo-5h-thiazolo(3,2-a)pyrimidine-2-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| AU7344887A (en) | Preparation of fatty acids | |
| GB8701198D0 (en) | Preparation of an ester |