IL84009A - 1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them - Google Patents

1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL84009A
IL84009A IL84009A IL8400987A IL84009A IL 84009 A IL84009 A IL 84009A IL 84009 A IL84009 A IL 84009A IL 8400987 A IL8400987 A IL 8400987A IL 84009 A IL84009 A IL 84009A
Authority
IL
Israel
Prior art keywords
lower alkyl
carbamoyl
indolo
pyrazino
tetrahydro
Prior art date
Application number
IL84009A
Other languages
English (en)
Other versions
IL84009A0 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL84009A0 publication Critical patent/IL84009A0/xx
Publication of IL84009A publication Critical patent/IL84009A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL84009A 1986-10-01 1987-09-28 1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them IL84009A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/914,028 US4737496A (en) 1986-10-01 1986-10-01 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

Publications (2)

Publication Number Publication Date
IL84009A0 IL84009A0 (en) 1988-02-29
IL84009A true IL84009A (en) 1992-01-15

Family

ID=25433828

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84009A IL84009A (en) 1986-10-01 1987-09-28 1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US4737496A (es)
EP (1) EP0266308B1 (es)
JP (1) JPS6396187A (es)
KR (1) KR880005134A (es)
AT (1) ATE65503T1 (es)
AU (1) AU605507B2 (es)
DD (1) DD275050A5 (es)
DE (1) DE3771652D1 (es)
DK (1) DK513087A (es)
ES (1) ES2044971T3 (es)
FI (1) FI874245A (es)
GR (1) GR3002362T3 (es)
HU (1) HU198937B (es)
IL (1) IL84009A (es)
NO (1) NO166186C (es)
NZ (1) NZ221975A (es)
PH (1) PH24754A (es)
PT (1) PT85822B (es)
ZA (1) ZA877360B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
CN103288830A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法
CN103288831A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓-6-酮的方法
CN103288828A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
CN110437236B (zh) * 2019-08-28 2020-08-18 青岛农业大学 一种吲哚-1,2-并1,4-苯并二氮杂卓类化合物及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA784475B (en) * 1977-10-05 1979-07-25 Ciba Geigy Ag Piperazinopyrrolobenzodiazepines
US4316900A (en) * 1977-10-05 1982-02-23 Ciba-Geigy Corporation Piperazinopyrrolobenzodiazepines
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
US4362666A (en) * 1979-08-22 1982-12-07 Ciba-Geigy Corporation Diazepinopyrrolobenzodiazepines
US4424221A (en) * 1982-09-28 1984-01-03 Ciba-Geigy Corporation Method of treating anxiety
US4529724A (en) * 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
US4587244A (en) * 1984-04-11 1986-05-06 Mcneilab, Inc. Amidine benzodiazepines, methods for their use and intermediates
US4547497A (en) * 1984-04-11 1985-10-15 Mcneilab, Inc. Amidine benzodiazepines, methods for their use and intermediates
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
PT85822B (pt) 1990-07-31
FI874245A0 (fi) 1987-09-28
DE3771652D1 (de) 1991-08-29
NO874111D0 (no) 1987-09-30
DK513087D0 (da) 1987-09-29
AU7909487A (en) 1988-04-14
ZA877360B (en) 1989-06-28
AU605507B2 (en) 1991-01-17
DD275050A5 (de) 1990-01-10
ATE65503T1 (de) 1991-08-15
NO874111L (no) 1988-04-05
HU198937B (en) 1989-12-28
US4737496A (en) 1988-04-12
EP0266308A1 (de) 1988-05-04
KR880005134A (ko) 1988-06-28
PT85822A (pt) 1987-10-01
HUT47284A (en) 1989-02-28
NO166186C (no) 1991-06-12
DK513087A (da) 1988-04-02
IL84009A0 (en) 1988-02-29
ES2044971T3 (es) 1994-01-16
NO166186B (no) 1991-03-04
FI874245A (fi) 1988-04-02
GR3002362T3 (en) 1992-12-30
EP0266308B1 (de) 1991-07-24
NZ221975A (en) 1990-02-26
JPS6396187A (ja) 1988-04-27
PH24754A (en) 1990-10-01

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Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees