IL83756A - Derivatives of 5-methyl-10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine and pharmaceutical compositions containing them - Google Patents

Derivatives of 5-methyl-10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine and pharmaceutical compositions containing them

Info

Publication number
IL83756A
IL83756A IL83756A IL8375687A IL83756A IL 83756 A IL83756 A IL 83756A IL 83756 A IL83756 A IL 83756A IL 8375687 A IL8375687 A IL 8375687A IL 83756 A IL83756 A IL 83756A
Authority
IL
Israel
Prior art keywords
cyclohepten
dibenzo
imine
dihydro
derivatives
Prior art date
Application number
IL83756A
Other languages
English (en)
Other versions
IL83756A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL83756A0 publication Critical patent/IL83756A0/xx
Publication of IL83756A publication Critical patent/IL83756A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL83756A 1986-09-08 1987-09-02 Derivatives of 5-methyl-10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine and pharmaceutical compositions containing them IL83756A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90494086A 1986-09-08 1986-09-08
US3639287A 1987-04-09 1987-04-09

Publications (2)

Publication Number Publication Date
IL83756A0 IL83756A0 (en) 1988-02-29
IL83756A true IL83756A (en) 1991-12-12

Family

ID=26713133

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83756A IL83756A (en) 1986-09-08 1987-09-02 Derivatives of 5-methyl-10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine and pharmaceutical compositions containing them

Country Status (11)

Country Link
EP (1) EP0264183B1 (xx)
KR (1) KR880003914A (xx)
AU (1) AU600752B2 (xx)
CA (1) CA1300606C (xx)
DE (1) DE3776064D1 (xx)
DK (1) DK464287A (xx)
ES (1) ES2033315T3 (xx)
GR (1) GR3003875T3 (xx)
IL (1) IL83756A (xx)
NZ (1) NZ221626A (xx)
PT (1) PT85657B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870079A (en) * 1986-09-08 1989-09-26 Merck & Co., Inc. Derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
NZ225634A (en) * 1987-08-10 1991-03-26 Merck & Co Inc 10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine derivatives and pharmaceutical compositions
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US4869791A (en) * 1988-06-24 1989-09-26 Merck & Co., Inc. Process for preparing 10,11-dihydro-11-exo-hydroxy-5-methyldibenzo[a,d]cyclohepten-5,10-imine
JPH07119224B2 (ja) * 1989-05-09 1995-12-20 アメリカ合衆国 癲癇およびコカイン嗜癖治療用の５―アミノカルボニル―５Ｈ―ジベンゾ〔ａ，ｄ〕シクロヘプテン―５，１０―イミン
AU4540193A (en) * 1992-06-17 1994-01-04 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Method of treating and protecting against central nervous system ischemia, hypoxia, degeneration, and trauma with a 5-aminocarbonyl-sh-dibenzo{a,d}cyclohepten-5,10-imine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399141A (en) * 1977-09-19 1983-08-16 Merck & Co., Inc. 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine

Also Published As

Publication number Publication date
IL83756A0 (en) 1988-02-29
PT85657B (pt) 1990-06-29
NZ221626A (en) 1989-11-28
AU600752B2 (en) 1990-08-23
GR3003875T3 (xx) 1993-03-16
ES2033315T3 (es) 1993-03-16
DK464287A (da) 1988-05-31
DE3776064D1 (de) 1992-02-27
EP0264183A1 (en) 1988-04-20
CA1300606C (en) 1992-05-12
KR880003914A (ko) 1988-05-31
AU7796087A (en) 1988-03-10
EP0264183B1 (en) 1992-01-15
DK464287D0 (da) 1987-09-07
PT85657A (en) 1987-10-01

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Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees