IL83462A - Composition of slow-release microspheres and the use of biologically active proteins and peptides - Google Patents
Composition of slow-release microspheres and the use of biologically active proteins and peptidesInfo
- Publication number
- IL83462A IL83462A IL8346287A IL8346287A IL83462A IL 83462 A IL83462 A IL 83462A IL 8346287 A IL8346287 A IL 8346287A IL 8346287 A IL8346287 A IL 8346287A IL 83462 A IL83462 A IL 83462A
- Authority
- IL
- Israel
- Prior art keywords
- growth hormone
- mixture
- composition
- fat
- biologically active
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 150
- 239000004005 microsphere Substances 0.000 title claims description 46
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 30
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 22
- 102000004169 proteins and genes Human genes 0.000 title claims description 19
- 108090000623 proteins and genes Proteins 0.000 title claims description 19
- 238000007911 parenteral administration Methods 0.000 title claims description 9
- 239000003981 vehicle Substances 0.000 claims description 38
- 241001465754 Metazoa Species 0.000 claims description 36
- 239000000122 growth hormone Substances 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 29
- 108010051696 Growth Hormone Proteins 0.000 claims description 26
- 102000018997 Growth Hormone Human genes 0.000 claims description 26
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
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- 238000004519 manufacturing process Methods 0.000 claims description 18
- 239000000872 buffer Substances 0.000 claims description 17
- 239000003755 preservative agent Substances 0.000 claims description 16
- 239000004094 surface-active agent Substances 0.000 claims description 16
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- 230000007935 neutral effect Effects 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 9
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 9
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- 238000001816 cooling Methods 0.000 claims description 7
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- 150000004696 coordination complex Chemical class 0.000 claims 1
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- 239000003925 fat Substances 0.000 description 26
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 14
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
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- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
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- 239000002253 acid Substances 0.000 description 2
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000007975 buffered saline Substances 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
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- 239000004166 Lanolin Substances 0.000 description 1
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- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
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- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
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- 235000010233 benzoic acid Nutrition 0.000 description 1
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- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
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- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89560886A | 1986-08-11 | 1986-08-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL83462A0 IL83462A0 (en) | 1988-01-31 |
| IL83462A true IL83462A (en) | 1994-01-25 |
Family
ID=25404759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8346287A IL83462A (en) | 1986-08-11 | 1987-08-06 | Composition of slow-release microspheres and the use of biologically active proteins and peptides |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0257368B1 (da) |
| JP (1) | JP2571790B2 (da) |
| AR (1) | AR243079A1 (da) |
| AT (1) | ATE74009T1 (da) |
| AU (1) | AU597708B2 (da) |
| CA (1) | CA1296627C (da) |
| DE (1) | DE3777721D1 (da) |
| DK (1) | DK169123B1 (da) |
| ES (1) | ES2039219T3 (da) |
| FI (1) | FI873465A (da) |
| GR (1) | GR3004138T3 (da) |
| HU (1) | HU203662B (da) |
| IE (1) | IE65146B1 (da) |
| IL (1) | IL83462A (da) |
| NZ (1) | NZ221391A (da) |
| ZA (1) | ZA875898B (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857505A (en) * | 1987-03-09 | 1989-08-15 | American Cyanamid Company | Sustained release compositions for parenteral administration and their use |
| GB8725427D0 (en) * | 1987-10-30 | 1987-12-02 | Lilly Industries Ltd | Somatotropin formulations |
| ATE130195T1 (de) * | 1988-07-26 | 1995-12-15 | Univ Rutgers | Vorrichtungen und verfahren zur wachstumsförderung bei bratgeflügel. |
| US5106631A (en) * | 1989-07-17 | 1992-04-21 | American Cyanamid Company | Cheese production |
| US5188895A (en) * | 1989-08-31 | 1993-02-23 | Mitsui Petrochemical Industries, Ltd. | Split fibers, integrated split fiber articles and method for preparing the same |
| WO1991005548A1 (en) * | 1989-10-10 | 1991-05-02 | Pitman-Moore, Inc. | Sustained release composition for macromolecular proteins |
| FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
| FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
| WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| DE69229779T2 (de) * | 1991-04-19 | 1999-12-23 | Lds Technologies, Inc. | Konvertierbare mikroemulsionsverbindungen |
| US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| DE69208765T2 (de) * | 1991-07-23 | 1996-09-26 | American Cyanamid Co | Stabile Zusammensetzungen für parenterale Verabrechung und ihre Verwendung |
| US5336488A (en) * | 1991-08-07 | 1994-08-09 | American Cyanamid Company | Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines |
| YU87892A (sh) * | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| IL103275A0 (en) * | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
| ES2107685T3 (es) * | 1992-10-16 | 1997-12-01 | Glaxo Group Ltd | Composiciones de ranitidina que enmascaran su sabor. |
| US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| AUPN366795A0 (en) | 1995-06-20 | 1995-07-13 | Peptide Technology Limited | Formulation for preventing reproductive function |
| CA2262578A1 (en) | 1996-08-07 | 1998-02-12 | Kunio Ito | Fat emulsion containing xanthine derivative |
| JP2001058955A (ja) * | 1999-06-17 | 2001-03-06 | Inst Of Physical & Chemical Res | 生理活性ペプチド徐放性製剤 |
| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
| US6967028B2 (en) | 2000-07-31 | 2005-11-22 | Mainelab | Prolonged release microspheres for injectable administration |
| ES2290095T3 (es) | 2000-12-27 | 2008-02-16 | Ares Trading S.A. | Microparticulas lipidicas por micronizacion criogenica. |
| JP2006518380A (ja) * | 2003-01-31 | 2006-08-10 | スミスクライン・ビーチャム・コーポレイション | 固体分散体組成物 |
| CN110036974A (zh) * | 2019-03-18 | 2019-07-23 | 香格里拉市春树养殖农民专业合作社 | 一种肉牛的养殖方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS537492B2 (da) * | 1973-02-12 | 1978-03-18 | ||
| EP0085036A1 (en) * | 1982-01-18 | 1983-08-03 | Monsanto Company | Method for improved bovine milk production |
| IT1190361B (it) * | 1985-05-30 | 1988-02-16 | Zambon Spa | Composizione farmaceutica in crema per uso dermale ed oftalmico |
-
1987
- 1987-08-04 EP EP87111217A patent/EP0257368B1/en not_active Expired - Lifetime
- 1987-08-04 AT AT87111217T patent/ATE74009T1/de not_active IP Right Cessation
- 1987-08-04 ES ES198787111217T patent/ES2039219T3/es not_active Expired - Lifetime
- 1987-08-04 DE DE8787111217T patent/DE3777721D1/de not_active Expired - Fee Related
- 1987-08-06 IL IL8346287A patent/IL83462A/en not_active IP Right Cessation
- 1987-08-07 CA CA000543953A patent/CA1296627C/en not_active Expired - Fee Related
- 1987-08-10 FI FI873465A patent/FI873465A/fi not_active Application Discontinuation
- 1987-08-10 DK DK414987A patent/DK169123B1/da not_active IP Right Cessation
- 1987-08-10 AU AU76725/87A patent/AU597708B2/en not_active Ceased
- 1987-08-10 NZ NZ221391A patent/NZ221391A/xx unknown
- 1987-08-10 IE IE212987A patent/IE65146B1/en not_active IP Right Cessation
- 1987-08-10 AR AR87308992A patent/AR243079A1/es active
- 1987-08-10 HU HU873619A patent/HU203662B/hu not_active IP Right Cessation
- 1987-08-10 ZA ZA875898A patent/ZA875898B/xx unknown
- 1987-08-11 JP JP62199239A patent/JP2571790B2/ja not_active Expired - Fee Related
-
1992
- 1992-03-26 GR GR910401178T patent/GR3004138T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL83462A0 (en) | 1988-01-31 |
| AU597708B2 (en) | 1990-06-07 |
| IE65146B1 (en) | 1995-10-04 |
| DK414987D0 (da) | 1987-08-10 |
| CA1296627C (en) | 1992-03-03 |
| IE872129L (en) | 1988-02-11 |
| EP0257368B1 (en) | 1992-03-25 |
| HU203662B (en) | 1991-09-30 |
| FI873465A0 (fi) | 1987-08-10 |
| DE3777721D1 (de) | 1992-04-30 |
| DK414987A (da) | 1988-02-12 |
| FI873465A (fi) | 1988-02-12 |
| EP0257368A1 (en) | 1988-03-02 |
| JP2571790B2 (ja) | 1997-01-16 |
| HUT45887A (en) | 1988-09-28 |
| ES2039219T3 (es) | 1993-09-16 |
| DK169123B1 (da) | 1994-08-22 |
| ATE74009T1 (de) | 1992-04-15 |
| GR3004138T3 (da) | 1993-03-31 |
| JPS6348223A (ja) | 1988-02-29 |
| NZ221391A (en) | 1990-08-28 |
| AU7672587A (en) | 1988-02-18 |
| ZA875898B (en) | 1988-02-12 |
| AR243079A1 (es) | 1993-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |