IL77676A - 7-(2-(2-amino-1,3-thiazol-4-yl)-2-carbazoyl-acetamino)-3-cephem-4-carboxylic acid derivatives - Google Patents
7-(2-(2-amino-1,3-thiazol-4-yl)-2-carbazoyl-acetamino)-3-cephem-4-carboxylic acid derivativesInfo
- Publication number
- IL77676A IL77676A IL8677676A IL7767686A IL77676A IL 77676 A IL77676 A IL 77676A IL 8677676 A IL8677676 A IL 8677676A IL 7767686 A IL7767686 A IL 7767686A IL 77676 A IL77676 A IL 77676A
- Authority
- IL
- Israel
- Prior art keywords
- carbazoyl
- acetamino
- cephem
- thiazol
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP858785 | 1985-01-21 | ||
JP1198685 | 1985-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL77676A true IL77676A (en) | 1990-09-17 |
Family
ID=26343130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8677676A IL77676A (en) | 1985-01-21 | 1986-01-21 | 7-(2-(2-amino-1,3-thiazol-4-yl)-2-carbazoyl-acetamino)-3-cephem-4-carboxylic acid derivatives |
Country Status (13)
Country | Link |
---|---|
US (1) | US4808711A (hu) |
EP (1) | EP0189287B1 (hu) |
JP (1) | JPS61267583A (hu) |
KR (1) | KR930007417B1 (hu) |
AU (1) | AU586215B2 (hu) |
CA (1) | CA1277977C (hu) |
DE (1) | DE3687279T2 (hu) |
DK (1) | DK27486A (hu) |
ES (1) | ES8706159A1 (hu) |
HU (1) | HU202538B (hu) |
IL (1) | IL77676A (hu) |
NZ (1) | NZ214864A (hu) |
PH (1) | PH22882A (hu) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE150507T1 (de) * | 1983-12-29 | 1987-02-26 | Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
EP0210815A3 (en) * | 1985-07-25 | 1988-04-20 | Beecham Group Plc | 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use |
ZA874696B (en) * | 1986-07-03 | 1988-01-04 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Acyl derivatives |
US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
FI872879A (fi) * | 1986-07-21 | 1988-01-22 | Sankei Yakuhin Kk | --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes. |
AT392969B (de) * | 1986-11-17 | 1991-07-25 | Sankei Yakuhin Kk | Beta-lactamverbindungen, verfahren zu ihrer herstellung, dieselben enthaltende pharmazeutischepraeparate zur behandlung von durch bakterien verursachte infektionskrankheiten |
DK170088A (da) * | 1987-04-10 | 1988-10-11 | Hoffmann La Roche | Acylderivater |
MC1921A1 (fr) * | 1987-04-10 | 1989-04-06 | Sankei Yakuhin Kk | Derives acyles |
FI883320A (fi) * | 1987-08-07 | 1989-02-08 | Sankei Yakuhin Kk | --laktam, dess framstaellning och mellanprodukter foer dess framstaellning. |
US5073550A (en) * | 1987-08-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Cephalosphorins with sulfur-containing oxyimino side chain |
EP0303172A3 (de) * | 1987-08-14 | 1991-05-15 | F. Hoffmann-La Roche Ag | Oxyimino-Cephalosporine |
US5138066A (en) * | 1987-08-14 | 1992-08-11 | Hoffmann-La Roche, Inc. | Intermediates for cephalosporins with sulfur-containing oxyimino side chain |
CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
EP0492277A3 (en) * | 1990-12-20 | 1992-10-14 | F. Hoffmann-La Roche Ag | Cephalosporin derivatives |
EP0550775A1 (en) * | 1992-01-07 | 1993-07-14 | F. Hoffmann-La Roche Ag | Cephalosporin derivatives |
US5318781A (en) * | 1993-04-06 | 1994-06-07 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
US5599988A (en) * | 1994-12-22 | 1997-02-04 | Smithkline Beecham Corporation | Large scale preparation of 2,4-dihydroxybenzaldehyde using a variation of the Vilsmeierhaack reaction and isolated intermediates |
DE19654920A1 (de) * | 1996-06-26 | 1998-01-08 | Gruenenthal Gmbh | Neue synthetische Catecholderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
US20130065874A1 (en) | 2011-09-09 | 2013-03-14 | Cubist Pharmaceuticals, Inc. | Methods for treating intrapulmonary infections |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
KR102226197B1 (ko) | 2013-03-15 | 2021-03-11 | 머크 샤프 앤드 돔 코포레이션 | 세프톨로잔 항균성 조성물 |
US20140274991A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
AU2014233637A1 (en) | 2013-09-09 | 2015-03-26 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1476312A (en) * | 1974-06-03 | 1977-06-10 | Beecham Group Ltd | Penicillins and cephalosporins |
US4091212A (en) * | 1976-11-26 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Hydrazinocarbonylamino cephalosporins 3-heterocyclicthio 7-hydrazinocarbonylamino acetylamino cephalosporins |
JPS609719B2 (ja) * | 1977-08-06 | 1985-03-12 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
DE150507T1 (de) * | 1983-12-29 | 1987-02-26 | Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
-
1986
- 1986-01-17 AU AU52449/86A patent/AU586215B2/en not_active Ceased
- 1986-01-17 NZ NZ214864A patent/NZ214864A/xx unknown
- 1986-01-17 US US06/819,831 patent/US4808711A/en not_active Expired - Fee Related
- 1986-01-17 DE DE8686300307T patent/DE3687279T2/de not_active Expired - Fee Related
- 1986-01-17 CA CA000499832A patent/CA1277977C/en not_active Expired - Fee Related
- 1986-01-17 EP EP86300307A patent/EP0189287B1/en not_active Expired - Lifetime
- 1986-01-17 JP JP61006281A patent/JPS61267583A/ja active Pending
- 1986-01-20 HU HU86264A patent/HU202538B/hu not_active IP Right Cessation
- 1986-01-20 KR KR1019860000306A patent/KR930007417B1/ko not_active IP Right Cessation
- 1986-01-20 DK DK27486A patent/DK27486A/da not_active Application Discontinuation
- 1986-01-21 PH PH33309A patent/PH22882A/en unknown
- 1986-01-21 ES ES551071A patent/ES8706159A1/es not_active Expired
- 1986-01-21 IL IL8677676A patent/IL77676A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3687279T2 (de) | 1993-05-13 |
DK27486D0 (da) | 1986-01-20 |
HU202538B (en) | 1991-03-28 |
PH22882A (en) | 1989-01-19 |
EP0189287A3 (en) | 1987-09-30 |
EP0189287B1 (en) | 1992-12-16 |
DE3687279D1 (de) | 1993-01-28 |
ES8706159A1 (es) | 1987-06-01 |
HUT41800A (en) | 1987-05-28 |
ES551071A0 (es) | 1987-06-01 |
EP0189287A2 (en) | 1986-07-30 |
KR930007417B1 (ko) | 1993-08-10 |
NZ214864A (en) | 1988-04-29 |
AU5244986A (en) | 1986-07-24 |
DK27486A (da) | 1986-07-22 |
AU586215B2 (en) | 1989-07-06 |
KR860005824A (ko) | 1986-08-13 |
JPS61267583A (ja) | 1986-11-27 |
US4808711A (en) | 1989-02-28 |
CA1277977C (en) | 1990-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RH | Patent void |