IL76142A - Monoclonal antibody specific to a human carcinoma tumor-associated antigen kc-4,hybrid cell lines producing the same,pharmaceutical compositions containing them and methods for the use thereof - Google Patents
Monoclonal antibody specific to a human carcinoma tumor-associated antigen kc-4,hybrid cell lines producing the same,pharmaceutical compositions containing them and methods for the use thereofInfo
- Publication number
- IL76142A IL76142A IL76142A IL7614285A IL76142A IL 76142 A IL76142 A IL 76142A IL 76142 A IL76142 A IL 76142A IL 7614285 A IL7614285 A IL 7614285A IL 76142 A IL76142 A IL 76142A
- Authority
- IL
- Israel
- Prior art keywords
- methods
- pharmaceutical compositions
- monoclonal antibody
- cell lines
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67032884A | 1984-11-09 | 1984-11-09 | |
US06/702,059 US4708930A (en) | 1984-11-09 | 1985-02-15 | Monoclonal antibody to a human carcinoma tumor associated antigen |
Publications (2)
Publication Number | Publication Date |
---|---|
IL76142A0 IL76142A0 (en) | 1985-12-31 |
IL76142A true IL76142A (en) | 1990-04-29 |
Family
ID=27100290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL76142A IL76142A (en) | 1984-11-09 | 1985-08-20 | Monoclonal antibody specific to a human carcinoma tumor-associated antigen kc-4,hybrid cell lines producing the same,pharmaceutical compositions containing them and methods for the use thereof |
Country Status (14)
Country | Link |
---|---|
US (1) | US4708930A (da) |
EP (1) | EP0201509B1 (da) |
KR (1) | KR900003923B1 (da) |
CN (1) | CN1009055B (da) |
AU (1) | AU593467B2 (da) |
BR (1) | BR8507031A (da) |
CA (1) | CA1243969A (da) |
DE (1) | DE3574730D1 (da) |
DK (1) | DK323486A (da) |
ES (1) | ES8705975A1 (da) |
HU (1) | HUT40692A (da) |
IL (1) | IL76142A (da) |
NO (1) | NO862641D0 (da) |
WO (1) | WO1986002945A1 (da) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5188967A (en) * | 1985-05-02 | 1993-02-23 | Institut Pasteur | Agents for the in vitro diagnosis of malignant cells originating in the digestive tract |
US5635389A (en) * | 1985-05-02 | 1997-06-03 | Institut Pasteur | Antibodies which recognize and bind human villin |
US4916055A (en) * | 1985-12-13 | 1990-04-10 | Baylor College Of Medicine | Detection of human cancer with a monoclonal antibody specific for antigen gp650 |
US4926869A (en) * | 1986-01-16 | 1990-05-22 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
EP0232871A3 (en) * | 1986-02-07 | 1989-03-15 | Yoshitomi Pharmaceutical Industries, Ltd. | Human monoclonal antibody, hybridoma producing the same and its use |
US4863851A (en) * | 1986-10-20 | 1989-09-05 | The Upjohn Company | Monoclonal antibody to prostate secretory protein |
DE3713301A1 (de) * | 1987-04-18 | 1988-11-03 | Becker Helmut Dipl Wirtsch Ing | Verfahren zur durchflussmengenmessung und thermischer durchflussgeber hierfuer |
CA1340927C (en) * | 1987-10-09 | 2000-03-14 | Peter S. Linsley | Method for increasing the sensitivity of assays for target ligand |
US5204450A (en) * | 1988-03-04 | 1993-04-20 | New England Deaconess Hospital Corporation | Carcinoma orosomucoid-related antigen, a monoclonal antibody thereto, and their uses |
US5241052A (en) * | 1988-03-04 | 1993-08-31 | New England Deaconess Hospital Corporation | Carcinoma orosomucoid-related antigen, a monoclonal antibody thereto, and their uses |
US4914021A (en) * | 1988-03-04 | 1990-04-03 | New England Deaconess Hospital Corporation | Carcinoma orosomucoid-related antigen, a monoclonal antibody thereto, and their uses |
US5171666A (en) * | 1988-04-22 | 1992-12-15 | Eli Lilly And Company | Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas |
US5242824A (en) * | 1988-12-22 | 1993-09-07 | Oncogen | Monoclonal antibody to human carcinomas |
US5134075A (en) * | 1989-02-17 | 1992-07-28 | Oncogen Limited Partnership | Monoclonal antibody to novel antigen associated with human tumors |
FR2645877B1 (fr) * | 1989-04-12 | 1991-07-05 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes |
US5171665A (en) * | 1989-04-17 | 1992-12-15 | Oncogen | Monoclonal antibody to novel antigen associated with human tumors |
US5980896A (en) * | 1989-06-30 | 1999-11-09 | Bristol-Myers Squibb Company | Antibodies reactive with human carcinomas |
US6020145A (en) * | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
IL94872A (en) * | 1989-06-30 | 1995-03-30 | Oncogen | Monoclonal or chimeric antibodies that react with human carcinoma, recombinant proteins that contain their anti-binding site, pharmaceutical preparations and kits that contain the |
EP0460607A3 (en) * | 1990-06-05 | 1992-04-01 | Bristol-Myers Squibb Company | Novel monoclonal antibody to novel antigen associated with human tumors |
AU5615594A (en) * | 1992-11-13 | 1994-06-08 | Cancer Research Fund Of Contra Costa | Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods |
CA2149529C (en) * | 1992-11-16 | 2006-05-02 | Fernado J. R. Do Couto | Peptides and anti-sense peptides with broad neoplastic specificity |
US5804187A (en) | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
US6281335B1 (en) | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
US5792852A (en) * | 1992-11-16 | 1998-08-11 | Cancer Research Fund Of Contra Costa | Polynucleotides encoding modified antibodies with human milk fat globule specificity |
CA2154266A1 (en) * | 1993-02-05 | 1994-08-18 | John F. Codington | Human carcinoma antigen (hca), hca antibodies, hca immunoassays, methods of imaging and therapy |
US5792456A (en) * | 1994-08-04 | 1998-08-11 | Bristol-Myers Squibb Company | Mutant BR96 antibodies reactive with human carcinomas |
US5728821A (en) * | 1994-08-04 | 1998-03-17 | Bristol-Myers Squibb Company | Mutant BR96 antibodies reactive with human carcinomas |
US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
US20020192211A1 (en) * | 1998-03-17 | 2002-12-19 | Hudziak Robert M. | Method of treating tumor cells by inhibiting growth factor receptor function |
US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US6471968B1 (en) | 2000-05-12 | 2002-10-29 | Regents Of The University Of Michigan | Multifunctional nanodevice platform |
ATE396265T1 (de) | 2000-06-28 | 2008-06-15 | Corixa Corp | Zusammensetzungen und verfahren für therapie und diagnose von lungenkrebs |
ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
US7101977B2 (en) | 2001-07-17 | 2006-09-05 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
DK2224012T3 (da) | 2001-12-17 | 2013-05-13 | Corixa Corp | Sammensætninger og fremgangsmåder til terapi og diagnose af inflammatoriske tarmsygdomme |
EP1670812A2 (en) * | 2003-09-05 | 2006-06-21 | The Scripps Research Institute | Ozonation products of cholesterol for the treatment and prevention of atherosclerosis and/or cardiovascular diseases |
WO2005023831A1 (en) * | 2003-09-05 | 2005-03-17 | The Scripps Research Institute | Detection of cholesterol ozonation products |
WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
US20090104119A1 (en) * | 2004-08-25 | 2009-04-23 | Majoros Istvan J | Dendrimer Based Compositions And Methods Of Using The Same |
US20070041934A1 (en) * | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
WO2007067730A2 (en) * | 2005-12-08 | 2007-06-14 | Medarex, Inc. | Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use |
US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
US7501179B2 (en) | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
JP2009541333A (ja) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
EP2049151A4 (en) | 2006-07-17 | 2010-03-24 | Quintessence Biosciences Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
AU2008275501A1 (en) * | 2007-04-19 | 2009-01-15 | The Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
US7890055B1 (en) * | 2007-07-09 | 2011-02-15 | Everlokt Corporation | Touch field compound field detector personal ID |
US8916135B2 (en) * | 2007-08-22 | 2014-12-23 | Colorado School Of Mines | Lanthanide nanoparticle conjugates and uses thereof |
JP2010540681A (ja) * | 2007-10-08 | 2010-12-24 | クインテッセンス バイオサイエンシズ,インコーポレーテッド | リボヌクレアーゼに基づく治療のための組成物及び方法 |
US8252834B2 (en) | 2008-03-12 | 2012-08-28 | The Regents Of The University Of Michigan | Dendrimer conjugates |
WO2010096464A1 (en) | 2009-02-18 | 2010-08-26 | Boyes Stephen G | Gold/lanthanide nanoparticle conjugates and uses thereof |
WO2010039861A2 (en) | 2008-09-30 | 2010-04-08 | The Regents Of The University Of Michigan | Dendrimer conjugates |
BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
CA2740125A1 (en) | 2008-10-09 | 2010-04-15 | Northeastern University | Multifunctional self-assembling polymeric nanosystems |
WO2010054321A2 (en) | 2008-11-07 | 2010-05-14 | The Regents Of The University Of Michigan | Methods of treating autoimmune disorders and/or inflammatory disorders |
CN102917699A (zh) | 2009-10-13 | 2013-02-06 | 密执安大学评议会 | 树枝状聚合物组合物和合成方法 |
US8912323B2 (en) | 2009-10-30 | 2014-12-16 | The Regents Of The University Of Michigan | Multifunctional small molecules |
US20110201076A1 (en) | 2010-01-22 | 2011-08-18 | Colorado School Of Mines | Harvesting micro algae |
EP2723365A1 (en) | 2011-06-21 | 2014-04-30 | Oncofactor Corporation | Compositions and methods for the therapy and diagnosis of cancer |
US9402911B2 (en) | 2011-12-08 | 2016-08-02 | The Regents Of The University Of Michigan | Multifunctional small molecules |
US9751936B2 (en) * | 2013-03-08 | 2017-09-05 | Regeneron Pharmaceuticals, Inc. | Human antibodies to serum resistance-associated protein from trypanosoma brucei rhodesiense |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
US4323546A (en) * | 1978-05-22 | 1982-04-06 | Nuc Med Inc. | Method and composition for cancer detection in humans |
US4472371A (en) * | 1979-10-29 | 1984-09-18 | Summa Medical Corporation | Radiolabeled antibody to anti-tumor associated antigen and process |
JPS57500169A (da) * | 1979-12-28 | 1982-01-28 | ||
US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4361544A (en) * | 1980-03-03 | 1982-11-30 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
US4348376A (en) * | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
US4359457A (en) * | 1980-09-30 | 1982-11-16 | Neville Jr David M | Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant |
US4381292A (en) * | 1980-11-14 | 1983-04-26 | The Board Of Trustees Of The Leland Stanford Jr. University | Anti-human T-lymphocyte monoclonal antibody |
US4522918A (en) * | 1981-12-15 | 1985-06-11 | Jeffery Schlom | Process for producing monoclonal antibodies reactive with human breast cancer |
EP0087898A1 (en) * | 1982-02-22 | 1983-09-07 | Cancer Research Campaign Technology Limited | Antibodies and antigens useful in the diagnosis and treatment of cancer |
US4507391A (en) * | 1982-04-02 | 1985-03-26 | Sloan-Kettering Institute For Cancer Research | Method for detecting the presence of GD3 ganglioside |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
US4569788A (en) * | 1983-05-18 | 1986-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies against non small cell lung cancer |
IL76877A (en) * | 1984-11-02 | 1991-11-21 | Oncogen | Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies |
DK276185D0 (da) * | 1984-11-09 | 1985-06-19 | Novo Industri As | Monoklonale antistoffer,fremgangsmaade til fremstilling af disse samt deres diagnostiske anvendelse |
JPS61258173A (ja) * | 1985-05-10 | 1986-11-15 | Akira Taniuchi | モノクロ−ナル抗体およびその製法ならびに用途 |
-
1985
- 1985-02-15 US US06/702,059 patent/US4708930A/en not_active Expired - Lifetime
- 1985-08-08 KR KR1019860700435A patent/KR900003923B1/ko active IP Right Grant
- 1985-08-08 WO PCT/US1985/001511 patent/WO1986002945A1/en active IP Right Grant
- 1985-08-08 HU HU853664A patent/HUT40692A/hu unknown
- 1985-08-08 EP EP85904190A patent/EP0201509B1/en not_active Expired
- 1985-08-08 AU AU47254/85A patent/AU593467B2/en not_active Ceased
- 1985-08-08 DE DE8585904190T patent/DE3574730D1/de not_active Expired - Fee Related
- 1985-08-08 BR BR8507031A patent/BR8507031A/pt unknown
- 1985-08-20 IL IL76142A patent/IL76142A/xx unknown
- 1985-08-21 ES ES546325A patent/ES8705975A1/es not_active Expired
- 1985-09-11 CA CA000490414A patent/CA1243969A/en not_active Expired
- 1985-11-02 CN CN85107599A patent/CN1009055B/zh not_active Expired
-
1986
- 1986-06-30 NO NO1986862641A patent/NO862641D0/no unknown
- 1986-07-07 DK DK323486A patent/DK323486A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO862641L (no) | 1986-06-30 |
KR880700061A (ko) | 1988-02-15 |
DK323486D0 (da) | 1986-07-07 |
DE3574730D1 (de) | 1990-01-18 |
DK323486A (da) | 1986-07-07 |
CN1009055B (zh) | 1990-08-08 |
CN85107599A (zh) | 1986-07-09 |
BR8507031A (pt) | 1987-01-06 |
AU4725485A (en) | 1986-06-03 |
HUT40692A (en) | 1987-01-28 |
IL76142A0 (en) | 1985-12-31 |
ES546325A0 (es) | 1987-05-16 |
ES8705975A1 (es) | 1987-05-16 |
WO1986002945A1 (en) | 1986-05-22 |
KR900003923B1 (ko) | 1990-06-04 |
EP0201509A1 (en) | 1986-11-20 |
EP0201509B1 (en) | 1989-12-13 |
CA1243969A (en) | 1988-11-01 |
US4708930A (en) | 1987-11-24 |
NO862641D0 (no) | 1986-06-30 |
AU593467B2 (en) | 1990-02-08 |
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