IL72943A0 - Process for the preparation of compounds containing carboxamide groups,in particular of peptides - Google Patents
Process for the preparation of compounds containing carboxamide groups,in particular of peptidesInfo
- Publication number
- IL72943A0 IL72943A0 IL72943A IL7294384A IL72943A0 IL 72943 A0 IL72943 A0 IL 72943A0 IL 72943 A IL72943 A IL 72943A IL 7294384 A IL7294384 A IL 7294384A IL 72943 A0 IL72943 A0 IL 72943A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- reaction
- compounds containing
- peptides
- carboxamide groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
- C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. A process for the preparation of compounds containing carboxamide groups by reaction of compounds which contain a carboxyl group, in the presence of dialkylphosphinic anhydrides, with compounds which contain a free amino group, which comprises maintaining the hydrogen ion concentration in the reaction mixture at an almost constant value in a range of 10**-5 to 10**-10 (mol/l) during the reaction and, after the reaction is complete, eliminating radicals which have, where appropriate, been introduced to protect other functional groups.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833333456 DE3333456A1 (en) | 1983-09-16 | 1983-09-16 | METHOD FOR PRODUCING COMPOUNDS CONTAINING CARBONIC ACID AMIDE, IN PARTICULAR PEPTIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL72943A0 true IL72943A0 (en) | 1984-12-31 |
| IL72943A IL72943A (en) | 1988-07-31 |
Family
ID=6209237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL72943A IL72943A (en) | 1983-09-16 | 1984-09-14 | Process for the preparation of peptides |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0135183B1 (en) |
| JP (1) | JPS6084249A (en) |
| AT (1) | ATE33251T1 (en) |
| AU (1) | AU570724B2 (en) |
| CA (1) | CA1285698C (en) |
| DE (2) | DE3333456A1 (en) |
| DK (1) | DK160041C (en) |
| ES (1) | ES535919A0 (en) |
| GR (1) | GR80370B (en) |
| HU (1) | HU189936B (en) |
| IE (1) | IE58082B1 (en) |
| IL (1) | IL72943A (en) |
| PT (1) | PT79195B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
| DE3333455A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2901843A1 (en) * | 1979-01-18 | 1980-07-31 | Hoechst Ag | METHOD FOR PRODUCING CARBONIC ACID AMIDES AND PEPTIDES |
| DE3101427A1 (en) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "METHOD FOR PRODUCING COMPOUNDS CONTAINING CARBONIC ACID AMIDE, IN PARTICULAR PEPTIDES" |
| DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
| DE3333455A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
-
1983
- 1983-09-16 DE DE19833333456 patent/DE3333456A1/en not_active Withdrawn
-
1984
- 1984-09-07 EP EP84110679A patent/EP0135183B1/en not_active Expired
- 1984-09-07 DE DE8484110679T patent/DE3470162D1/en not_active Expired
- 1984-09-07 AT AT84110679T patent/ATE33251T1/en not_active IP Right Cessation
- 1984-09-10 HU HU843418A patent/HU189936B/en unknown
- 1984-09-13 PT PT79195A patent/PT79195B/en active IP Right Revival
- 1984-09-13 CA CA000463073A patent/CA1285698C/en not_active Expired - Lifetime
- 1984-09-14 JP JP59191870A patent/JPS6084249A/en active Granted
- 1984-09-14 DK DK440184A patent/DK160041C/en not_active IP Right Cessation
- 1984-09-14 IE IE235284A patent/IE58082B1/en not_active IP Right Cessation
- 1984-09-14 GR GR80370A patent/GR80370B/en unknown
- 1984-09-14 ES ES535919A patent/ES535919A0/en active Granted
- 1984-09-14 AU AU33073/84A patent/AU570724B2/en not_active Expired
- 1984-09-14 IL IL72943A patent/IL72943A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8505939A1 (en) | 1985-06-16 |
| ATE33251T1 (en) | 1988-04-15 |
| ES535919A0 (en) | 1985-06-16 |
| HU189936B (en) | 1986-08-28 |
| EP0135183B1 (en) | 1988-03-30 |
| IL72943A (en) | 1988-07-31 |
| EP0135183A3 (en) | 1986-03-05 |
| AU570724B2 (en) | 1988-03-24 |
| PT79195A (en) | 1984-10-01 |
| DE3333456A1 (en) | 1985-04-11 |
| IE58082B1 (en) | 1993-06-30 |
| JPS6084249A (en) | 1985-05-13 |
| HUT36083A (en) | 1985-08-28 |
| DK160041C (en) | 1991-06-10 |
| DK440184A (en) | 1985-03-17 |
| CA1285698C (en) | 1991-07-02 |
| DK160041B (en) | 1991-01-21 |
| DE3470162D1 (en) | 1988-05-05 |
| JPH0417177B2 (en) | 1992-03-25 |
| EP0135183A2 (en) | 1985-03-27 |
| GR80370B (en) | 1985-01-11 |
| AU3307384A (en) | 1985-03-21 |
| DK440184D0 (en) | 1984-09-14 |
| PT79195B (en) | 1986-09-10 |
| IE842352L (en) | 1985-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH | Patent void | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed |