DK440184A - PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACID AMIDE SUBSTANCES, PARTICULARS OF PEPTIDES - Google Patents

PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACID AMIDE SUBSTANCES, PARTICULARS OF PEPTIDES Download PDF

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Publication number
DK440184A
DK440184A DK440184A DK440184A DK440184A DK 440184 A DK440184 A DK 440184A DK 440184 A DK440184 A DK 440184A DK 440184 A DK440184 A DK 440184A DK 440184 A DK440184 A DK 440184A
Authority
DK
Denmark
Prior art keywords
preparation
particulars
peptides
reaction
procedure
Prior art date
Application number
DK440184A
Other languages
Danish (da)
Other versions
DK160041C (en
DK160041B (en
DK440184D0 (en
Inventor
Hans Wissmann
Volker Teetz
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK440184D0 publication Critical patent/DK440184D0/en
Publication of DK440184A publication Critical patent/DK440184A/en
Publication of DK160041B publication Critical patent/DK160041B/en
Application granted granted Critical
Publication of DK160041C publication Critical patent/DK160041C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. A process for the preparation of compounds containing carboxamide groups by reaction of compounds which contain a carboxyl group, in the presence of dialkylphosphinic anhydrides, with compounds which contain a free amino group, which comprises maintaining the hydrogen ion concentration in the reaction mixture at an almost constant value in a range of 10**-5 to 10**-10 (mol/l) during the reaction and, after the reaction is complete, eliminating radicals which have, where appropriate, been introduced to protect other functional groups.
DK440184A 1983-09-16 1984-09-14 PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACIDAMIDE GROUP, COMPOUNDS OF PEPTIDES DK160041C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3333456 1983-09-16
DE19833333456 DE3333456A1 (en) 1983-09-16 1983-09-16 METHOD FOR PRODUCING COMPOUNDS CONTAINING CARBONIC ACID AMIDE, IN PARTICULAR PEPTIDES

Publications (4)

Publication Number Publication Date
DK440184D0 DK440184D0 (en) 1984-09-14
DK440184A true DK440184A (en) 1985-03-17
DK160041B DK160041B (en) 1991-01-21
DK160041C DK160041C (en) 1991-06-10

Family

ID=6209237

Family Applications (1)

Application Number Title Priority Date Filing Date
DK440184A DK160041C (en) 1983-09-16 1984-09-14 PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACIDAMIDE GROUP, COMPOUNDS OF PEPTIDES

Country Status (13)

Country Link
EP (1) EP0135183B1 (en)
JP (1) JPS6084249A (en)
AT (1) ATE33251T1 (en)
AU (1) AU570724B2 (en)
CA (1) CA1285698C (en)
DE (2) DE3333456A1 (en)
DK (1) DK160041C (en)
ES (1) ES8505939A1 (en)
GR (1) GR80370B (en)
HU (1) HU189936B (en)
IE (1) IE58082B1 (en)
IL (1) IL72943A (en)
PT (1) PT79195B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333455A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2901843A1 (en) * 1979-01-18 1980-07-31 Hoechst Ag METHOD FOR PRODUCING CARBONIC ACID AMIDES AND PEPTIDES
DE3101427A1 (en) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "METHOD FOR PRODUCING COMPOUNDS CONTAINING CARBONIC ACID AMIDE, IN PARTICULAR PEPTIDES"
DE3333455A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS

Also Published As

Publication number Publication date
DK160041C (en) 1991-06-10
DK160041B (en) 1991-01-21
EP0135183B1 (en) 1988-03-30
HU189936B (en) 1986-08-28
JPS6084249A (en) 1985-05-13
IE842352L (en) 1985-03-16
ES535919A0 (en) 1985-06-16
PT79195B (en) 1986-09-10
AU3307384A (en) 1985-03-21
CA1285698C (en) 1991-07-02
DE3333456A1 (en) 1985-04-11
GR80370B (en) 1985-01-11
HUT36083A (en) 1985-08-28
ATE33251T1 (en) 1988-04-15
ES8505939A1 (en) 1985-06-16
IE58082B1 (en) 1993-06-30
DK440184D0 (en) 1984-09-14
IL72943A (en) 1988-07-31
AU570724B2 (en) 1988-03-24
JPH0417177B2 (en) 1992-03-25
IL72943A0 (en) 1984-12-31
EP0135183A3 (en) 1986-03-05
DE3470162D1 (en) 1988-05-05
EP0135183A2 (en) 1985-03-27
PT79195A (en) 1984-10-01

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PUP Patent expired