IL72817A0 - Nitrosourea derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Nitrosourea derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL72817A0 IL72817A0 IL72817A IL7281784A IL72817A0 IL 72817 A0 IL72817 A0 IL 72817A0 IL 72817 A IL72817 A IL 72817A IL 7281784 A IL7281784 A IL 7281784A IL 72817 A0 IL72817 A0 IL 72817A0
- Authority
- IL
- Israel
- Prior art keywords
- formula
- hydrogen
- represent
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the formula (I), in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR1R2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'1R'2 group, where R1 and/or R'1 each represent a hydrogen atom or formula (II), Hal being a halogen, and R2 and/or R'2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R'' can represent hydrogen or OH, provided that at least, X represents formula (III), with R1 representing formula (IV) or Y represents formula (V) with R'1 representing formula (VI) and provided that, either R' represents hydrogen or R'' represents hydrogen, and R' and R'' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8313878A FR2551068B1 (en) | 1983-08-30 | 1983-08-30 | NOVEL NITROSOURES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL72817A0 true IL72817A0 (en) | 1984-11-30 |
| IL72817A IL72817A (en) | 1989-09-10 |
Family
ID=9291872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL72817A IL72817A (en) | 1983-08-30 | 1984-08-30 | 3-and/or 6-(3-(2-haloethyl)-3-nitrosoureido)-sugars,their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0143675B1 (en) |
| JP (1) | JPS60502105A (en) |
| KR (1) | KR920001690B1 (en) |
| AT (1) | ATE50264T1 (en) |
| CA (1) | CA1257587A (en) |
| DE (1) | DE3481305D1 (en) |
| DK (1) | DK194585A (en) |
| ES (1) | ES535903A0 (en) |
| FR (1) | FR2551068B1 (en) |
| GR (1) | GR80249B (en) |
| IL (1) | IL72817A (en) |
| NZ (1) | NZ209397A (en) |
| PT (1) | PT79158B (en) |
| WO (1) | WO1985001050A1 (en) |
| ZA (1) | ZA846783B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614303B1 (en) * | 1987-04-22 | 1990-06-08 | Sanofi Sa | NITROSOURED DERIVATIVES, THEIR NEW PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS. |
| FR2614304A1 (en) * | 1987-04-22 | 1988-10-28 | Sanofi Sa | NITROSOUREES DERIVATIVES, THEIR NEW PREPARATION METHOD AND THERAPEUTIC APPLICATIONS THEREOF. |
| DE19524515A1 (en) * | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharide conjugates |
| WO1998043628A1 (en) * | 1997-04-02 | 1998-10-08 | Viktor Veniaminovich Tets | Antitumoral drugs (chlonidan) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940383A (en) * | 1974-12-12 | 1976-02-24 | Stanford Research Institute | Streptozotocin analogs |
| JPS554324A (en) * | 1978-06-26 | 1980-01-12 | Kaken Pharmaceut Co Ltd | Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent |
| JPS5681596A (en) * | 1979-12-07 | 1981-07-03 | Tokyo Tanabe Co Ltd | Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation |
| JPS57200397A (en) * | 1981-06-03 | 1982-12-08 | Akira Kimura | Novel aldohexopyranose-, aldopentopyranose-, or and medicament composition comprising it aldopentofuranose- nitrosourea compound, its preparation |
-
1983
- 1983-08-30 FR FR8313878A patent/FR2551068B1/en not_active Expired
-
1984
- 1984-08-29 JP JP59503417A patent/JPS60502105A/en active Pending
- 1984-08-29 WO PCT/EP1984/000260 patent/WO1985001050A1/en unknown
- 1984-08-29 KR KR1019850700021A patent/KR920001690B1/en not_active IP Right Cessation
- 1984-08-30 DE DE8484401743T patent/DE3481305D1/en not_active Expired - Fee Related
- 1984-08-30 PT PT79158A patent/PT79158B/en not_active IP Right Cessation
- 1984-08-30 NZ NZ209397A patent/NZ209397A/en unknown
- 1984-08-30 AT AT84401743T patent/ATE50264T1/en not_active IP Right Cessation
- 1984-08-30 GR GR80249A patent/GR80249B/en unknown
- 1984-08-30 EP EP84401743A patent/EP0143675B1/en not_active Expired - Lifetime
- 1984-08-30 ES ES535903A patent/ES535903A0/en active Granted
- 1984-08-30 ZA ZA846783A patent/ZA846783B/en unknown
- 1984-08-30 CA CA000462200A patent/CA1257587A/en not_active Expired
- 1984-08-30 IL IL72817A patent/IL72817A/en unknown
-
1985
- 1985-04-30 DK DK194585A patent/DK194585A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU580009B2 (en) | 1988-12-22 |
| DK194585D0 (en) | 1985-04-30 |
| FR2551068B1 (en) | 1986-03-21 |
| DE3481305D1 (en) | 1990-03-15 |
| CA1257587A (en) | 1989-07-18 |
| EP0143675A1 (en) | 1985-06-05 |
| ZA846783B (en) | 1985-04-24 |
| ES8602031A1 (en) | 1985-12-01 |
| GR80249B (en) | 1984-12-14 |
| ATE50264T1 (en) | 1990-02-15 |
| ES535903A0 (en) | 1985-12-01 |
| AU3392684A (en) | 1985-03-29 |
| IL72817A (en) | 1989-09-10 |
| NZ209397A (en) | 1988-04-29 |
| KR920001690B1 (en) | 1992-02-22 |
| PT79158B (en) | 1986-08-19 |
| WO1985001050A1 (en) | 1985-03-14 |
| DK194585A (en) | 1985-04-30 |
| PT79158A (en) | 1984-09-01 |
| FR2551068A1 (en) | 1985-03-01 |
| JPS60502105A (en) | 1985-12-05 |
| EP0143675B1 (en) | 1990-02-07 |
| KR850700031A (en) | 1985-10-21 |
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