DK194585A - NITROSOUR INGREDIENT DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND MEDICINES CONTAINING THEM - Google Patents
NITROSOUR INGREDIENT DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND MEDICINES CONTAINING THEM Download PDFInfo
- Publication number
- DK194585A DK194585A DK194585A DK194585A DK194585A DK 194585 A DK194585 A DK 194585A DK 194585 A DK194585 A DK 194585A DK 194585 A DK194585 A DK 194585A DK 194585 A DK194585 A DK 194585A
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- hydrogen
- represent
- hydrogen atom
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the formula (I), in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR1R2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'1R'2 group, where R1 and/or R'1 each represent a hydrogen atom or formula (II), Hal being a halogen, and R2 and/or R'2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R'' can represent hydrogen or OH, provided that at least, X represents formula (III), with R1 representing formula (IV) or Y represents formula (V) with R'1 representing formula (VI) and provided that, either R' represents hydrogen or R'' represents hydrogen, and R' and R'' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.
Description
hvor Hal er halogen, og og/eller R^ hver kan repræsentere et hydrogenatom eller en alkylgruppe med 1-6 carbonatomer, R’ og R" kan repræsentere hydrogen eller OH, med det forbehold, at i det mindste X repræsentererwherein Hal is halogen and and / or R 1 may each represent a hydrogen atom or an alkyl group of 1-6 carbon atoms, R 1 and R "may represent hydrogen or OH, with the proviso that at least X represents
hvor Rj repræsentererwhere Rj represents
eller Y repræsentereror Y represents
hvor R'^ repræsentererwhere R 1 represents
og med det forbehold, at enten R' eller R" er hydrogen, og idet R' og R" ikke samtidigt kan være hydrogen.and with the proviso that either R 'or R "is hydrogen and that R' and R" cannot simultaneously be hydrogen.
Forbindelserne har antitumor-virkning.The compounds have antitumor effect.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8313878 | 1983-08-30 | ||
| FR8313878A FR2551068B1 (en) | 1983-08-30 | 1983-08-30 | NOVEL NITROSOURES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM |
| PCT/EP1984/000260 WO1985001050A1 (en) | 1983-08-30 | 1984-08-29 | Nitrosourea derivatives, process for their preparation and medicaments containing them |
| EP8400260 | 1984-08-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK194585D0 DK194585D0 (en) | 1985-04-30 |
| DK194585A true DK194585A (en) | 1985-04-30 |
Family
ID=9291872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK194585A DK194585A (en) | 1983-08-30 | 1985-04-30 | NITROSOUR INGREDIENT DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND MEDICINES CONTAINING THEM |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0143675B1 (en) |
| JP (1) | JPS60502105A (en) |
| KR (1) | KR920001690B1 (en) |
| AT (1) | ATE50264T1 (en) |
| CA (1) | CA1257587A (en) |
| DE (1) | DE3481305D1 (en) |
| DK (1) | DK194585A (en) |
| ES (1) | ES535903A0 (en) |
| FR (1) | FR2551068B1 (en) |
| GR (1) | GR80249B (en) |
| IL (1) | IL72817A (en) |
| NZ (1) | NZ209397A (en) |
| PT (1) | PT79158B (en) |
| WO (1) | WO1985001050A1 (en) |
| ZA (1) | ZA846783B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614303B1 (en) * | 1987-04-22 | 1990-06-08 | Sanofi Sa | NITROSOURED DERIVATIVES, THEIR NEW PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS. |
| FR2614304A1 (en) * | 1987-04-22 | 1988-10-28 | Sanofi Sa | NITROSOUREES DERIVATIVES, THEIR NEW PREPARATION METHOD AND THERAPEUTIC APPLICATIONS THEREOF. |
| DE19524515A1 (en) * | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharide conjugates |
| WO1998043628A1 (en) * | 1997-04-02 | 1998-10-08 | Viktor Veniaminovich Tets | Antitumoral drugs (chlonidan) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940383A (en) * | 1974-12-12 | 1976-02-24 | Stanford Research Institute | Streptozotocin analogs |
| JPS554324A (en) * | 1978-06-26 | 1980-01-12 | Kaken Pharmaceut Co Ltd | Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent |
| JPS5681596A (en) * | 1979-12-07 | 1981-07-03 | Tokyo Tanabe Co Ltd | Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation |
| JPS57200397A (en) * | 1981-06-03 | 1982-12-08 | Akira Kimura | Novel aldohexopyranose-, aldopentopyranose-, or and medicament composition comprising it aldopentofuranose- nitrosourea compound, its preparation |
-
1983
- 1983-08-30 FR FR8313878A patent/FR2551068B1/en not_active Expired
-
1984
- 1984-08-29 WO PCT/EP1984/000260 patent/WO1985001050A1/en unknown
- 1984-08-29 JP JP59503417A patent/JPS60502105A/en active Pending
- 1984-08-29 KR KR1019850700021A patent/KR920001690B1/en not_active IP Right Cessation
- 1984-08-30 ZA ZA846783A patent/ZA846783B/en unknown
- 1984-08-30 NZ NZ209397A patent/NZ209397A/en unknown
- 1984-08-30 IL IL72817A patent/IL72817A/en unknown
- 1984-08-30 ES ES535903A patent/ES535903A0/en active Granted
- 1984-08-30 PT PT79158A patent/PT79158B/en not_active IP Right Cessation
- 1984-08-30 GR GR80249A patent/GR80249B/en unknown
- 1984-08-30 AT AT84401743T patent/ATE50264T1/en not_active IP Right Cessation
- 1984-08-30 DE DE8484401743T patent/DE3481305D1/en not_active Expired - Fee Related
- 1984-08-30 CA CA000462200A patent/CA1257587A/en not_active Expired
- 1984-08-30 EP EP84401743A patent/EP0143675B1/en not_active Expired - Lifetime
-
1985
- 1985-04-30 DK DK194585A patent/DK194585A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0143675B1 (en) | 1990-02-07 |
| PT79158A (en) | 1984-09-01 |
| CA1257587A (en) | 1989-07-18 |
| NZ209397A (en) | 1988-04-29 |
| WO1985001050A1 (en) | 1985-03-14 |
| ZA846783B (en) | 1985-04-24 |
| DE3481305D1 (en) | 1990-03-15 |
| IL72817A0 (en) | 1984-11-30 |
| FR2551068B1 (en) | 1986-03-21 |
| EP0143675A1 (en) | 1985-06-05 |
| DK194585D0 (en) | 1985-04-30 |
| ATE50264T1 (en) | 1990-02-15 |
| ES8602031A1 (en) | 1985-12-01 |
| FR2551068A1 (en) | 1985-03-01 |
| ES535903A0 (en) | 1985-12-01 |
| AU580009B2 (en) | 1988-12-22 |
| JPS60502105A (en) | 1985-12-05 |
| KR850700031A (en) | 1985-10-21 |
| PT79158B (en) | 1986-08-19 |
| IL72817A (en) | 1989-09-10 |
| KR920001690B1 (en) | 1992-02-22 |
| GR80249B (en) | 1984-12-14 |
| AU3392684A (en) | 1985-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |