IL72817A - 3-and/or 6-(3-(2-haloethyl)-3-nitrosoureido)-sugars,their preparation and pharmaceutical compositions containing them - Google Patents

3-and/or 6-(3-(2-haloethyl)-3-nitrosoureido)-sugars,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72817A
IL72817A IL72817A IL7281784A IL72817A IL 72817 A IL72817 A IL 72817A IL 72817 A IL72817 A IL 72817A IL 7281784 A IL7281784 A IL 7281784A IL 72817 A IL72817 A IL 72817A
Authority
IL
Israel
Prior art keywords
formula
hydrogen
represent
preparation
pharmaceutical compositions
Prior art date
Application number
IL72817A
Other versions
IL72817A0 (en
Original Assignee
Dropic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dropic filed Critical Dropic
Publication of IL72817A0 publication Critical patent/IL72817A0/en
Publication of IL72817A publication Critical patent/IL72817A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the formula (I), in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR1R2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'1R'2 group, where R1 and/or R'1 each represent a hydrogen atom or formula (II), Hal being a halogen, and R2 and/or R'2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R'' can represent hydrogen or OH, provided that at least, X represents formula (III), with R1 representing formula (IV) or Y represents formula (V) with R'1 representing formula (VI) and provided that, either R' represents hydrogen or R'' represents hydrogen, and R' and R'' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.
IL72817A 1983-08-30 1984-08-30 3-and/or 6-(3-(2-haloethyl)-3-nitrosoureido)-sugars,their preparation and pharmaceutical compositions containing them IL72817A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8313878A FR2551068B1 (en) 1983-08-30 1983-08-30 NOVEL NITROSOURES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
IL72817A0 IL72817A0 (en) 1984-11-30
IL72817A true IL72817A (en) 1989-09-10

Family

ID=9291872

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72817A IL72817A (en) 1983-08-30 1984-08-30 3-and/or 6-(3-(2-haloethyl)-3-nitrosoureido)-sugars,their preparation and pharmaceutical compositions containing them

Country Status (15)

Country Link
EP (1) EP0143675B1 (en)
JP (1) JPS60502105A (en)
KR (1) KR920001690B1 (en)
AT (1) ATE50264T1 (en)
CA (1) CA1257587A (en)
DE (1) DE3481305D1 (en)
DK (1) DK194585A (en)
ES (1) ES8602031A1 (en)
FR (1) FR2551068B1 (en)
GR (1) GR80249B (en)
IL (1) IL72817A (en)
NZ (1) NZ209397A (en)
PT (1) PT79158B (en)
WO (1) WO1985001050A1 (en)
ZA (1) ZA846783B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614303B1 (en) * 1987-04-22 1990-06-08 Sanofi Sa NITROSOURED DERIVATIVES, THEIR NEW PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS.
FR2614304A1 (en) * 1987-04-22 1988-10-28 Sanofi Sa NITROSOUREES DERIVATIVES, THEIR NEW PREPARATION METHOD AND THERAPEUTIC APPLICATIONS THEREOF.
DE19524515A1 (en) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharide conjugates
WO1998043628A1 (en) * 1997-04-02 1998-10-08 Viktor Veniaminovich Tets Antitumoral drugs (chlonidan)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940383A (en) * 1974-12-12 1976-02-24 Stanford Research Institute Streptozotocin analogs
JPS554324A (en) * 1978-06-26 1980-01-12 Kaken Pharmaceut Co Ltd Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent
JPS5681596A (en) * 1979-12-07 1981-07-03 Tokyo Tanabe Co Ltd Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation
JPS57200397A (en) * 1981-06-03 1982-12-08 Akira Kimura Novel aldohexopyranose-, aldopentopyranose-, or and medicament composition comprising it aldopentofuranose- nitrosourea compound, its preparation

Also Published As

Publication number Publication date
DK194585D0 (en) 1985-04-30
PT79158A (en) 1984-09-01
KR850700031A (en) 1985-10-21
DE3481305D1 (en) 1990-03-15
DK194585A (en) 1985-04-30
EP0143675A1 (en) 1985-06-05
ATE50264T1 (en) 1990-02-15
ZA846783B (en) 1985-04-24
FR2551068A1 (en) 1985-03-01
ES535903A0 (en) 1985-12-01
GR80249B (en) 1984-12-14
IL72817A0 (en) 1984-11-30
AU580009B2 (en) 1988-12-22
CA1257587A (en) 1989-07-18
FR2551068B1 (en) 1986-03-21
EP0143675B1 (en) 1990-02-07
NZ209397A (en) 1988-04-29
PT79158B (en) 1986-08-19
WO1985001050A1 (en) 1985-03-14
JPS60502105A (en) 1985-12-05
ES8602031A1 (en) 1985-12-01
AU3392684A (en) 1985-03-29
KR920001690B1 (en) 1992-02-22

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