IL69473A - 1,7-dihydro-pyrrolo(3,4-e)(1,4)diazepin-2(3h)-one derivatives,a process for preparing them and anticonvulsant and antianxiety compositions containing them - Google Patents
1,7-dihydro-pyrrolo(3,4-e)(1,4)diazepin-2(3h)-one derivatives,a process for preparing them and anticonvulsant and antianxiety compositions containing themInfo
- Publication number
- IL69473A IL69473A IL69473A IL6947383A IL69473A IL 69473 A IL69473 A IL 69473A IL 69473 A IL69473 A IL 69473A IL 6947383 A IL6947383 A IL 6947383A IL 69473 A IL69473 A IL 69473A
- Authority
- IL
- Israel
- Prior art keywords
- diazepin
- anticonvulsant
- pyrrolo
- dihydro
- derivatives
- Prior art date
Links
- NCCPPLQKOSIGFQ-UHFFFAOYSA-N 3,7-dihydro-1h-pyrrolo[3,4-e][1,4]diazepin-2-one Chemical class N1C(=O)CN=CC2=CNC=C21 NCCPPLQKOSIGFQ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- 229960003965 antiepileptics Drugs 0.000 title abstract 2
- 239000002249 anxiolytic agent Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000000049 anti-anxiety effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001246 bromo group Chemical group Br* 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ZDJJKOOESFJHGL-UHFFFAOYSA-N pyrrolo[3,2-c]diazepine Chemical class N1=CC=CC2=NC=CC2=N1 ZDJJKOOESFJHGL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8225582 | 1982-09-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL69473A0 IL69473A0 (en) | 1983-11-30 |
| IL69473A true IL69473A (en) | 1985-12-31 |
Family
ID=10532762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL69473A IL69473A (en) | 1982-09-08 | 1983-08-12 | 1,7-dihydro-pyrrolo(3,4-e)(1,4)diazepin-2(3h)-one derivatives,a process for preparing them and anticonvulsant and antianxiety compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4508730A (de) |
| EP (1) | EP0102602B1 (de) |
| JP (1) | JPS5965093A (de) |
| KR (1) | KR910000417B1 (de) |
| AT (1) | ATE51230T1 (de) |
| AU (1) | AU566404B2 (de) |
| CA (1) | CA1199633A (de) |
| DE (1) | DE3381355D1 (de) |
| DK (1) | DK161077C (de) |
| ES (2) | ES525442A0 (de) |
| GR (1) | GR79626B (de) |
| IE (1) | IE56043B1 (de) |
| IL (1) | IL69473A (de) |
| ZA (1) | ZA835899B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60208488A (ja) * | 1984-04-03 | 1985-10-21 | Nippon Mining Co Ltd | スラグからの有価金属の回収法 |
| CN105164135A (zh) | 2013-02-22 | 2015-12-16 | 拜耳医药股份有限公司 | 4-取代的吡咯并二氮杂卓和吡唑并二氮杂卓 |
| EP2958922A1 (de) | 2013-02-22 | 2015-12-30 | Bayer Pharma Aktiengesellschaft | Pyrrolo- und pyrazolo-triazolodiazepine als bet-proteininhibitoren zur behandlung von hyper-proliferativen erkrankungen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553210A (en) * | 1968-12-16 | 1971-01-05 | Parke Davis & Co | 3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1h)-one, 7-oxide compounds |
| US3553207A (en) * | 1968-12-16 | 1971-01-05 | Parke Davis & Co | Phenylpyrazolodiazepinone compounds |
| GB1433103A (en) * | 1974-03-20 | 1976-04-22 | Lepetit Spa | Pharmacologically active pyrrolodiazepines |
| GR76455B (de) * | 1981-06-04 | 1984-08-10 | Lepetit Spa | |
| IT1167788B (it) * | 1981-06-08 | 1987-05-13 | Lepetit Spa | Derivati pirrolo-diazepinici |
-
1983
- 1983-08-09 US US06/521,774 patent/US4508730A/en not_active Expired - Fee Related
- 1983-08-11 AU AU17900/83A patent/AU566404B2/en not_active Ceased
- 1983-08-11 ZA ZA835899A patent/ZA835899B/xx unknown
- 1983-08-12 IL IL69473A patent/IL69473A/xx unknown
- 1983-08-27 DE DE8383108446T patent/DE3381355D1/de not_active Expired - Lifetime
- 1983-08-27 AT AT83108446T patent/ATE51230T1/de not_active IP Right Cessation
- 1983-08-27 EP EP83108446A patent/EP0102602B1/de not_active Expired - Lifetime
- 1983-08-29 GR GR72324A patent/GR79626B/el unknown
- 1983-08-30 DK DK394483A patent/DK161077C/da active
- 1983-09-07 ES ES525442A patent/ES525442A0/es active Granted
- 1983-09-07 JP JP58163392A patent/JPS5965093A/ja active Granted
- 1983-09-07 IE IE2098/83A patent/IE56043B1/en not_active IP Right Cessation
- 1983-09-07 CA CA000436167A patent/CA1199633A/en not_active Expired
- 1983-09-08 KR KR1019830004230A patent/KR910000417B1/ko not_active Expired
-
1984
- 1984-05-14 ES ES532487A patent/ES8507551A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES532487A0 (es) | 1985-09-01 |
| KR840006248A (ko) | 1984-11-22 |
| ES8503000A1 (es) | 1985-02-01 |
| JPH0447672B2 (de) | 1992-08-04 |
| ZA835899B (en) | 1984-07-25 |
| AU1790083A (en) | 1984-03-15 |
| IE56043B1 (en) | 1991-03-27 |
| ES525442A0 (es) | 1985-02-01 |
| ES8507551A1 (es) | 1985-09-01 |
| CA1199633A (en) | 1986-01-21 |
| AU566404B2 (en) | 1987-10-22 |
| JPS5965093A (ja) | 1984-04-13 |
| DE3381355D1 (de) | 1990-04-26 |
| EP0102602B1 (de) | 1990-03-21 |
| ATE51230T1 (de) | 1990-04-15 |
| DK394483A (da) | 1984-03-09 |
| US4508730A (en) | 1985-04-02 |
| IE832098L (en) | 1984-03-08 |
| IL69473A0 (en) | 1983-11-30 |
| DK161077C (da) | 1991-11-18 |
| DK161077B (da) | 1991-05-27 |
| EP0102602A1 (de) | 1984-03-14 |
| GR79626B (de) | 1984-10-31 |
| DK394483D0 (da) | 1983-08-30 |
| KR910000417B1 (ko) | 1991-01-25 |
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