IL67219A - Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract - Google Patents

Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract

Info

Publication number
IL67219A
IL67219A IL67219A IL6721982A IL67219A IL 67219 A IL67219 A IL 67219A IL 67219 A IL67219 A IL 67219A IL 6721982 A IL6721982 A IL 6721982A IL 67219 A IL67219 A IL 67219A
Authority
IL
Israel
Prior art keywords
unseparated
indole
preparation
direct method
rosea extract
Prior art date
Application number
IL67219A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL67219A publication Critical patent/IL67219A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL67219A 1981-11-16 1982-11-10 Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract IL67219A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/321,662 US4375432A (en) 1981-05-12 1981-11-16 Method of preparing vincristine

Publications (1)

Publication Number Publication Date
IL67219A true IL67219A (en) 1985-09-29

Family

ID=23251481

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67219A IL67219A (en) 1981-11-16 1982-11-10 Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract

Country Status (12)

Country Link
US (1) US4375432A (el)
EP (1) EP0079785B1 (el)
JP (1) JPS5890591A (el)
KR (1) KR860000488B1 (el)
CA (1) CA1180328A (el)
DE (1) DE3277200D1 (el)
DK (1) DK161254C (el)
GB (1) GB2109378B (el)
GR (1) GR77791B (el)
HU (1) HU189620B (el)
IE (1) IE54172B1 (el)
IL (1) IL67219A (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190219B (en) * 1984-01-06 1986-08-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives
FR2582651B1 (fr) * 1985-06-03 1987-08-28 Pf Medicament Procede de preparation de vincristine
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JP2003513756A (ja) * 1999-11-12 2003-04-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 放射性治療と細胞周期インヒビターとの組合せの組成物
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
CN115540503B (zh) * 2022-10-28 2024-04-23 广州白云山汉方现代药业有限公司 一种硫酸长春新碱三元溶剂体系下的程序性干燥方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354163A (en) * 1966-12-15 1967-11-21 Eli Lillty And Company Nu-desmethylvinblastine
GB1382460A (en) * 1972-12-04 1975-01-29 Richter Gedeon Vegyeszet Vincristine separation process
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
US4110330A (en) * 1977-05-27 1978-08-29 Eli Lilly And Company 5'-Acetonylvincristine and related compounds
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
HU183385B (en) * 1980-04-02 1984-04-28 Lilly Co Eli Process for preparing vinca dimer derivatives
JPS57188596A (en) * 1981-05-12 1982-11-19 Lilly Co Eli Manufacture of vinca dimer

Also Published As

Publication number Publication date
GR77791B (el) 1984-09-25
DK161254B (da) 1991-06-17
DE3277200D1 (en) 1987-10-15
JPS5890591A (ja) 1983-05-30
CA1180328A (en) 1985-01-02
DK504882A (da) 1983-05-17
KR840002399A (ko) 1984-07-02
EP0079785A2 (en) 1983-05-25
IE54172B1 (en) 1989-07-05
EP0079785B1 (en) 1987-09-09
EP0079785A3 (en) 1984-03-28
US4375432A (en) 1983-03-01
JPH049792B2 (el) 1992-02-21
DK161254C (da) 1991-12-02
GB2109378A (en) 1983-06-02
IE822714L (en) 1983-05-16
KR860000488B1 (ko) 1986-04-30
HU189620B (en) 1986-07-28
GB2109378B (en) 1985-07-17

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Legal Events

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