IL66835A - 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them - Google Patents
1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL66835A IL66835A IL66835A IL6683582A IL66835A IL 66835 A IL66835 A IL 66835A IL 66835 A IL66835 A IL 66835A IL 6683582 A IL6683582 A IL 6683582A IL 66835 A IL66835 A IL 66835A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- alkyl
- group
- aralkyl
- aryl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 19
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 230000000572 bronchospasmolytic effect Effects 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8128875 | 1981-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL66835A0 IL66835A0 (en) | 1982-12-31 |
| IL66835A true IL66835A (en) | 1988-05-31 |
Family
ID=10524710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL66835A IL66835A (en) | 1981-09-24 | 1982-09-17 | 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4472400A (cs) |
| EP (1) | EP0076199B1 (cs) |
| JP (1) | JPS5865292A (cs) |
| AT (1) | ATE24509T1 (cs) |
| AU (1) | AU554959B2 (cs) |
| CA (1) | CA1193597A (cs) |
| DE (1) | DE3274860D1 (cs) |
| DK (1) | DK160308C (cs) |
| ES (1) | ES8400440A1 (cs) |
| FI (1) | FI73435C (cs) |
| GB (1) | GB2108495B (cs) |
| GR (1) | GR78044B (cs) |
| HU (1) | HU186975B (cs) |
| IE (1) | IE53858B1 (cs) |
| IL (1) | IL66835A (cs) |
| MA (1) | MA19604A1 (cs) |
| PT (1) | PT75602B (cs) |
| ZA (1) | ZA826891B (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5442062A (en) * | 1991-10-24 | 1995-08-15 | The Upjohn Company | Imidazole derivatives and pharmaceutical compositions containing the same |
| ES2149989T3 (es) * | 1994-05-24 | 2000-11-16 | Hoffmann La Roche | Derivados triciclicos de dicarbonilo. |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| US6897213B1 (en) | 1995-11-21 | 2005-05-24 | Warner-Lambert Company | Heterocycles as cholecystokinin (CCK) ligands |
| CN1149214C (zh) * | 1998-12-04 | 2004-05-12 | 东丽株式会社 | 三唑并衍生物和含有它们作为有效组分的趋化因子抑制剂 |
| FR2792938B1 (fr) | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
| PA8539501A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| EP1285922A1 (en) * | 2001-08-13 | 2003-02-26 | Warner-Lambert Company | 1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors |
| FR2832711B1 (fr) | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| CN1891704A (zh) * | 2005-07-08 | 2007-01-10 | 中国科学院上海药物研究所 | 一类二肽酶四抑制剂及其制备方法和用途 |
| CN115197225B (zh) * | 2021-09-03 | 2023-04-11 | 贵州大学 | 一种五元杂环并喹唑啉酮类化合物及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50116498A (cs) * | 1974-02-27 | 1975-09-11 | ||
| US4145419A (en) * | 1976-05-21 | 1979-03-20 | Roussel Uclaf | Novel imidazobenzoxazines |
| GB1596652A (en) * | 1977-01-20 | 1981-08-26 | Roussel Lab Ltd | Imidazo (1,2-a) quinoline-2-carboxylic acid and derivatives |
| GB1576077A (en) * | 1977-04-13 | 1980-10-01 | Roussel Lab Ltd | 4,5-dihydro-4-oxophyrrolo(1,2-)-quinoxaline-2-carboxylic acids and derivatives |
| SE444319B (sv) * | 1977-11-18 | 1986-04-07 | Roussel Uclaf | Nya imidazobensoxazinderivat, forfarande for framstellning derav och farmaceutiska kompositioner innehallande dessa foreningar |
| SE439308B (sv) * | 1978-08-02 | 1985-06-10 | Roussel Uclaf | Imidazo(1,2-a)kinoxaliner och farmaceutiska kompositioner derav |
| DD139715A1 (de) * | 1978-09-29 | 1980-01-16 | Karl Kottke | Verfahren zur herstellung von 1-substituierten 4-aryl-s-triazolo(4,3-a)chinazolonen-(5) |
| SE441449B (sv) * | 1979-02-09 | 1985-10-07 | Roussel Uclaf | Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat |
| FR2448541A1 (fr) * | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| ZA81708B (en) * | 1980-02-14 | 1982-06-30 | Roussel Uclaf | Triazoloquinazolinone derivatives |
-
1982
- 1982-09-17 IL IL66835A patent/IL66835A/xx unknown
- 1982-09-20 AT AT82401697T patent/ATE24509T1/de not_active IP Right Cessation
- 1982-09-20 ZA ZA826891A patent/ZA826891B/xx unknown
- 1982-09-20 EP EP82401697A patent/EP0076199B1/fr not_active Expired
- 1982-09-20 DE DE8282401697T patent/DE3274860D1/de not_active Expired
- 1982-09-21 US US06/420,798 patent/US4472400A/en not_active Expired - Fee Related
- 1982-09-22 AU AU88623/82A patent/AU554959B2/en not_active Ceased
- 1982-09-22 DK DK420682A patent/DK160308C/da not_active IP Right Cessation
- 1982-09-22 GR GR69335A patent/GR78044B/el unknown
- 1982-09-23 MA MA19816A patent/MA19604A1/fr unknown
- 1982-09-23 GB GB08227126A patent/GB2108495B/en not_active Expired
- 1982-09-23 PT PT75602A patent/PT75602B/pt not_active IP Right Cessation
- 1982-09-23 ES ES515904A patent/ES8400440A1/es not_active Expired
- 1982-09-23 CA CA000412016A patent/CA1193597A/fr not_active Expired
- 1982-09-23 IE IE2310/82A patent/IE53858B1/en not_active IP Right Cessation
- 1982-09-23 FI FI823278A patent/FI73435C/fi not_active IP Right Cessation
- 1982-09-24 HU HU823090A patent/HU186975B/hu not_active IP Right Cessation
- 1982-09-24 JP JP57165197A patent/JPS5865292A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ATE24509T1 (de) | 1987-01-15 |
| GR78044B (cs) | 1984-09-26 |
| IE822310L (en) | 1983-03-24 |
| IL66835A0 (en) | 1982-12-31 |
| DK160308B (da) | 1991-02-25 |
| PT75602A (fr) | 1982-10-01 |
| FI73435B (fi) | 1987-06-30 |
| DK420682A (da) | 1983-03-25 |
| DE3274860D1 (en) | 1987-02-05 |
| AU8862382A (en) | 1983-03-31 |
| HU186975B (en) | 1985-10-28 |
| JPS5865292A (ja) | 1983-04-18 |
| FI823278A0 (fi) | 1982-09-23 |
| GB2108495B (en) | 1985-07-24 |
| ES515904A0 (es) | 1983-10-16 |
| DK160308C (da) | 1991-07-29 |
| FI73435C (fi) | 1987-10-09 |
| EP0076199A3 (en) | 1984-03-21 |
| PT75602B (fr) | 1985-12-09 |
| GB2108495A (en) | 1983-05-18 |
| FI823278L (fi) | 1983-03-25 |
| US4472400A (en) | 1984-09-18 |
| CA1193597A (fr) | 1985-09-17 |
| MA19604A1 (fr) | 1983-04-01 |
| JPH0322389B2 (cs) | 1991-03-26 |
| ZA826891B (en) | 1983-10-26 |
| IE53858B1 (en) | 1989-03-29 |
| ES8400440A1 (es) | 1983-10-16 |
| EP0076199A2 (fr) | 1983-04-06 |
| EP0076199B1 (fr) | 1986-12-30 |
| AU554959B2 (en) | 1986-09-11 |
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