IL65382A - Cross-linked cytotoxic peroxidase-oxidase system,its preparation and use - Google Patents
Cross-linked cytotoxic peroxidase-oxidase system,its preparation and useInfo
- Publication number
- IL65382A IL65382A IL65382A IL6538282A IL65382A IL 65382 A IL65382 A IL 65382A IL 65382 A IL65382 A IL 65382A IL 6538282 A IL6538282 A IL 6538282A IL 65382 A IL65382 A IL 65382A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- tumor
- injection
- peroxidase
- immobilized
- Prior art date
Links
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 210000000987 immune system Anatomy 0.000 abstract 3
- 238000002513 implantation Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 208000010454 Experimental Liver Neoplasms Diseases 0.000 abstract 1
- 108010015776 Glucose oxidase Proteins 0.000 abstract 1
- 239000004366 Glucose oxidase Substances 0.000 abstract 1
- 108010093096 Immobilized Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 102000003992 Peroxidases Human genes 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 229940116332 glucose oxidase Drugs 0.000 abstract 1
- 235000019420 glucose oxidase Nutrition 0.000 abstract 1
- 108010046301 glucose peroxidase Proteins 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000007928 intraperitoneal injection Substances 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000005909 tumor killing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/18—Multi-enzyme systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03004—Glucose oxidase (1.1.3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/251,694 US4486408A (en) | 1981-04-07 | 1981-04-07 | Insoluble crosslinked cytotoxic oxidase-peroxidase system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL65382A0 IL65382A0 (en) | 1982-05-31 |
| IL65382A true IL65382A (en) | 1986-04-29 |
Family
ID=22953019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL65382A IL65382A (en) | 1981-04-07 | 1982-03-30 | Cross-linked cytotoxic peroxidase-oxidase system,its preparation and use |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4486408A (en:Method) |
| EP (1) | EP0062434B1 (en:Method) |
| JP (1) | JPS57177694A (en:Method) |
| AR (1) | AR229260A1 (en:Method) |
| AT (1) | ATE15813T1 (en:Method) |
| AU (1) | AU556620B2 (en:Method) |
| CA (1) | CA1187791A (en:Method) |
| DE (1) | DE3266476D1 (en:Method) |
| DK (1) | DK155082A (en:Method) |
| IL (1) | IL65382A (en:Method) |
| IN (1) | IN156471B (en:Method) |
| NO (1) | NO158004C (en:Method) |
| ZA (1) | ZA821924B (en:Method) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236610A1 (en) * | 1986-03-13 | 1987-09-16 | Laclede Professional Products, Inc. | Enzymatic bandages and pads |
| US4576817A (en) * | 1984-06-07 | 1986-03-18 | Laclede Professional Products, Inc. | Enzymatic bandages and pads |
| SE8500341L (sv) * | 1985-01-24 | 1986-07-25 | Pharmacia Ab | Desinfektionssats samt sett for desinfektion |
| US4974929A (en) * | 1987-09-22 | 1990-12-04 | Baxter International, Inc. | Fiber optical probe connector for physiologic measurement devices |
| AU4402589A (en) * | 1988-09-28 | 1990-04-18 | Ideon Corporation | Combination enzyme immunotherapeutics |
| FR2646777B1 (fr) * | 1989-05-12 | 1993-09-03 | Bio Serae Lab | Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications |
| US5486360A (en) * | 1993-04-22 | 1996-01-23 | St. Joseph Health Centre | Method of treating tumour cells using catalase |
| CA2150029A1 (en) * | 1993-09-22 | 1995-03-30 | Spencer H. Lin | Immobilization of chemically cross-linked proteins on solid supports |
| US7192766B2 (en) * | 2001-10-23 | 2007-03-20 | Medtronic Minimed, Inc. | Sensor containing molded solidified protein |
| WO2013006762A2 (en) * | 2011-07-06 | 2013-01-10 | The Regents Of The University Of California | Multiple-enzyme nanocomplexes |
| KR20250004257A (ko) * | 2022-04-13 | 2025-01-07 | 엑스옥세미스 인코퍼레이티드 | 고형 암을 치료하기 위한 조성물 및 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004979A (en) * | 1968-03-29 | 1977-01-25 | Agence Nationale De Valorisation De La Recherche (Anvar) | Preparation of active proteins cross-linked to inactive proteins |
| US4178362A (en) * | 1969-06-03 | 1979-12-11 | Telec S.A. | Enzymatic dentifrices |
| US3638558A (en) * | 1970-03-26 | 1972-02-01 | Burger King Corp | Cooking apparatus for comestibles immersed in heated oil |
| JPS528795B2 (en:Method) * | 1971-12-30 | 1977-03-11 | ||
| DE2214442C3 (de) * | 1972-03-24 | 1981-09-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Überführung von Glucose in Gluconsäure |
| DE2307904A1 (de) * | 1973-02-17 | 1974-08-29 | Hoechst Ag | Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen |
| DK146942C (da) * | 1978-04-19 | 1984-07-30 | Novo Industri As | Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt |
| DE2911192A1 (de) * | 1979-03-22 | 1980-10-02 | Boehringer Sohn Ingelheim | Neuartiges immobilisiertes glucoseoxidase-katalasepraeparat und seine verwendung zur enzymatischen glucoseoxidation |
-
1981
- 1981-04-07 US US06/251,694 patent/US4486408A/en not_active Expired - Fee Related
-
1982
- 1982-03-19 AT AT82301451T patent/ATE15813T1/de not_active IP Right Cessation
- 1982-03-19 DE DE8282301451T patent/DE3266476D1/de not_active Expired
- 1982-03-19 EP EP82301451A patent/EP0062434B1/en not_active Expired
- 1982-03-19 AU AU81739/82A patent/AU556620B2/en not_active Ceased
- 1982-03-22 ZA ZA821924A patent/ZA821924B/xx unknown
- 1982-03-30 IL IL65382A patent/IL65382A/xx unknown
- 1982-03-31 IN IN360/CAL/82A patent/IN156471B/en unknown
- 1982-04-05 DK DK155082A patent/DK155082A/da not_active IP Right Cessation
- 1982-04-05 AR AR289004A patent/AR229260A1/es active
- 1982-04-06 NO NO821167A patent/NO158004C/no unknown
- 1982-04-07 CA CA000400618A patent/CA1187791A/en not_active Expired
- 1982-04-07 JP JP57057947A patent/JPS57177694A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA821924B (en) | 1983-04-27 |
| EP0062434B1 (en) | 1985-09-25 |
| NO158004B (no) | 1988-03-21 |
| CA1187791A (en) | 1985-05-28 |
| AR229260A1 (es) | 1983-07-15 |
| AU556620B2 (en) | 1986-11-13 |
| NO821167L (no) | 1982-10-08 |
| DK155082A (da) | 1982-10-08 |
| NO158004C (no) | 1988-06-29 |
| DE3266476D1 (en) | 1985-10-31 |
| IN156471B (en:Method) | 1985-08-10 |
| AU8173982A (en) | 1982-10-14 |
| IL65382A0 (en) | 1982-05-31 |
| US4486408A (en) | 1984-12-04 |
| JPS57177694A (en) | 1982-11-01 |
| ATE15813T1 (de) | 1985-10-15 |
| EP0062434A1 (en) | 1982-10-13 |
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