ZA821924B - Insoluble crosslinked cytotoxic oxidase-peroxidase system - Google Patents

Insoluble crosslinked cytotoxic oxidase-peroxidase system

Info

Publication number
ZA821924B
ZA821924B ZA821924A ZA821924A ZA821924B ZA 821924 B ZA821924 B ZA 821924B ZA 821924 A ZA821924 A ZA 821924A ZA 821924 A ZA821924 A ZA 821924A ZA 821924 B ZA821924 B ZA 821924B
Authority
ZA
South Africa
Prior art keywords
oxidase
cytotoxic
insoluble crosslinked
peroxidase system
peroxidase
Prior art date
Application number
ZA821924A
Other languages
English (en)
Inventor
Johnathan L Kiel
J Everse
Original Assignee
Johnathan L Kiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnathan L Kiel filed Critical Johnathan L Kiel
Publication of ZA821924B publication Critical patent/ZA821924B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/18—Multi-enzyme systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA821924A 1981-04-07 1982-03-22 Insoluble crosslinked cytotoxic oxidase-peroxidase system ZA821924B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/251,694 US4486408A (en) 1981-04-07 1981-04-07 Insoluble crosslinked cytotoxic oxidase-peroxidase system

Publications (1)

Publication Number Publication Date
ZA821924B true ZA821924B (en) 1983-04-27

Family

ID=22953019

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA821924A ZA821924B (en) 1981-04-07 1982-03-22 Insoluble crosslinked cytotoxic oxidase-peroxidase system

Country Status (13)

Country Link
US (1) US4486408A (en:Method)
EP (1) EP0062434B1 (en:Method)
JP (1) JPS57177694A (en:Method)
AR (1) AR229260A1 (en:Method)
AT (1) ATE15813T1 (en:Method)
AU (1) AU556620B2 (en:Method)
CA (1) CA1187791A (en:Method)
DE (1) DE3266476D1 (en:Method)
DK (1) DK155082A (en:Method)
IL (1) IL65382A (en:Method)
IN (1) IN156471B (en:Method)
NO (1) NO158004C (en:Method)
ZA (1) ZA821924B (en:Method)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236610A1 (en) * 1986-03-13 1987-09-16 Laclede Professional Products, Inc. Enzymatic bandages and pads
US4576817A (en) * 1984-06-07 1986-03-18 Laclede Professional Products, Inc. Enzymatic bandages and pads
SE8500341L (sv) * 1985-01-24 1986-07-25 Pharmacia Ab Desinfektionssats samt sett for desinfektion
US4974929A (en) * 1987-09-22 1990-12-04 Baxter International, Inc. Fiber optical probe connector for physiologic measurement devices
AU4402589A (en) * 1988-09-28 1990-04-18 Ideon Corporation Combination enzyme immunotherapeutics
FR2646777B1 (fr) * 1989-05-12 1993-09-03 Bio Serae Lab Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications
US5486360A (en) * 1993-04-22 1996-01-23 St. Joseph Health Centre Method of treating tumour cells using catalase
CA2150029A1 (en) * 1993-09-22 1995-03-30 Spencer H. Lin Immobilization of chemically cross-linked proteins on solid supports
US7192766B2 (en) * 2001-10-23 2007-03-20 Medtronic Minimed, Inc. Sensor containing molded solidified protein
WO2013006762A2 (en) * 2011-07-06 2013-01-10 The Regents Of The University Of California Multiple-enzyme nanocomplexes
KR20250004257A (ko) * 2022-04-13 2025-01-07 엑스옥세미스 인코퍼레이티드 고형 암을 치료하기 위한 조성물 및 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004979A (en) * 1968-03-29 1977-01-25 Agence Nationale De Valorisation De La Recherche (Anvar) Preparation of active proteins cross-linked to inactive proteins
US4178362A (en) * 1969-06-03 1979-12-11 Telec S.A. Enzymatic dentifrices
US3638558A (en) * 1970-03-26 1972-02-01 Burger King Corp Cooking apparatus for comestibles immersed in heated oil
JPS528795B2 (en:Method) * 1971-12-30 1977-03-11
DE2214442C3 (de) * 1972-03-24 1981-09-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Überführung von Glucose in Gluconsäure
DE2307904A1 (de) * 1973-02-17 1974-08-29 Hoechst Ag Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen
DK146942C (da) * 1978-04-19 1984-07-30 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DE2911192A1 (de) * 1979-03-22 1980-10-02 Boehringer Sohn Ingelheim Neuartiges immobilisiertes glucoseoxidase-katalasepraeparat und seine verwendung zur enzymatischen glucoseoxidation

Also Published As

Publication number Publication date
EP0062434B1 (en) 1985-09-25
NO158004B (no) 1988-03-21
CA1187791A (en) 1985-05-28
AR229260A1 (es) 1983-07-15
AU556620B2 (en) 1986-11-13
NO821167L (no) 1982-10-08
DK155082A (da) 1982-10-08
NO158004C (no) 1988-06-29
DE3266476D1 (en) 1985-10-31
IN156471B (en:Method) 1985-08-10
AU8173982A (en) 1982-10-14
IL65382A0 (en) 1982-05-31
US4486408A (en) 1984-12-04
JPS57177694A (en) 1982-11-01
ATE15813T1 (de) 1985-10-15
IL65382A (en) 1986-04-29
EP0062434A1 (en) 1982-10-13

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