ES8606407A1 - Un procedimiento para preparar conjugados de galactosil-insulina - Google Patents

Un procedimiento para preparar conjugados de galactosil-insulina

Info

Publication number
ES8606407A1
ES8606407A1 ES530759A ES530759A ES8606407A1 ES 8606407 A1 ES8606407 A1 ES 8606407A1 ES 530759 A ES530759 A ES 530759A ES 530759 A ES530759 A ES 530759A ES 8606407 A1 ES8606407 A1 ES 8606407A1
Authority
ES
Spain
Prior art keywords
insulin
conjugates
galactosyl
conjugates useful
insulin conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530759A
Other languages
English (en)
Other versions
ES530759A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of ES8606407A1 publication Critical patent/ES8606407A1/es
Publication of ES530759A0 publication Critical patent/ES530759A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR CONJUGADOS DE GALACTOSIL-INSULINA. COMPRENDE: A) DISOLVER ACIDO LACTOBIONICO O ACIDO MELIBIONICO Y N,NK-DICICLOHEXILCARBODIIMIDA EN UN DISOLVENTE APROTICO COMO PIRIDINA, A UNA TEMPERATURA DE 0JC DURANTE 0,5 HORAS; B) AÑADIR N-HIDROXISUCCINIMIDA AL DISOLVENTE APROTICO; C) DESPUES DE LA OPERACION (B), AGITAR EL DISOLVENTE A 3JC DURANTE 20 HORAS PARA FORMAR EL ESTER LACTOBIONATO O MELIOBIONATO DE N-HIDROXISUCCINIMIDA; D) DISOLVER EL ESTER LACTOBIONATO O MELIBIONATO DE N-HIDROXISUCCINIMIDA EN AGUA PARA FORMAR UNA SOLUCION ACUOSA DEL MISMO; E) AÑADIR LA SOLUCION ACUOSA GOTA A GOTA DURANTE UN PERIODO DE 30 MINUTOS A UNA SOLUCION SALINA QUE CONTIENE INSULINA MANTENIDA A UN PH DE 7 U 8,5, Y A TEMPERTURA AMBIENTE; Y F) SEPARAR LOS CONJUGADOS DE LACTOBIONIL-INSULINA O MELIBIONOL-INSULINA DE LA SOLUCION SALINA.
ES530759A 1983-03-21 1984-03-20 Un procedimiento para preparar conjugados de galactosil-insulina Expired ES8606407A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47755583A 1983-03-21 1983-03-21

Publications (2)

Publication Number Publication Date
ES8606407A1 true ES8606407A1 (es) 1986-04-01
ES530759A0 ES530759A0 (es) 1986-04-01

Family

ID=23896415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530759A Expired ES8606407A1 (es) 1983-03-21 1984-03-20 Un procedimiento para preparar conjugados de galactosil-insulina

Country Status (6)

Country Link
EP (1) EP0119650A3 (es)
JP (1) JPS6011426A (es)
AU (1) AU2589984A (es)
ES (1) ES8606407A1 (es)
PH (1) PH22300A (es)
ZA (1) ZA842051B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8504099D0 (en) * 1985-02-18 1985-03-20 Wellcome Found Physiologically active substances
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
WO1997000882A1 (en) * 1995-06-23 1997-01-09 Oxford Glycosciences (Uk) Limited Therapeutic compounds
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds
NZ594248A (en) 2009-01-28 2015-03-27 Smartcells Inc Conjugate based systems for controlled drug delivery
RU2011135730A (ru) 2009-01-28 2013-03-10 Смартселлз, Инк. Кристаллические инсулин-коньюгаты
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
US8846103B2 (en) 2009-01-28 2014-09-30 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
US9518087B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
EP3052134B1 (en) 2013-10-04 2021-05-05 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
JP6744227B2 (ja) 2014-02-21 2020-08-19 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） 糖標的化治療剤
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
EP0009842B1 (en) * 1978-10-02 1982-11-10 THE PROCTER & GAMBLE COMPANY Liposomes for drug delivery and composition containing a liposome drug system
US4348387A (en) * 1979-07-31 1982-09-07 The Rockefeller University Method and system for the controlled release of biologically active substances to a body fluid

Also Published As

Publication number Publication date
EP0119650A2 (en) 1984-09-26
EP0119650A3 (en) 1987-09-30
ZA842051B (en) 1984-10-31
PH22300A (en) 1988-07-22
JPS6011426A (ja) 1985-01-21
AU2589984A (en) 1984-09-27
ES530759A0 (es) 1986-04-01

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