IL53996A - 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL53996A
IL53996A IL53996A IL5399678A IL53996A IL 53996 A IL53996 A IL 53996A IL 53996 A IL53996 A IL 53996A IL 5399678 A IL5399678 A IL 5399678A IL 53996 A IL53996 A IL 53996A
Authority
IL
Israel
Prior art keywords
fluoroalkylthio
diphenyl
substituted
preparation
pharmaceutical compositions
Prior art date
Application number
IL53996A
Other languages
English (en)
Other versions
IL53996A0 (en
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of IL53996A0 publication Critical patent/IL53996A0/xx
Publication of IL53996A publication Critical patent/IL53996A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL53996A 1977-02-09 1978-02-08 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them IL53996A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76721977A 1977-02-09 1977-02-09
US05/865,831 US4182769A (en) 1977-02-09 1978-01-05 Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones

Publications (2)

Publication Number Publication Date
IL53996A0 IL53996A0 (en) 1978-04-30
IL53996A true IL53996A (en) 1982-04-30

Family

ID=27117878

Family Applications (1)

Application Number Title Priority Date Filing Date
IL53996A IL53996A (en) 1977-02-09 1978-02-08 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4182769A (de)
JP (1) JPS53130665A (de)
AR (1) AR221590A1 (de)
AT (1) AT363076B (de)
AU (1) AU524360B2 (de)
CA (1) CA1107286A (de)
CH (1) CH643834A5 (de)
DE (1) DE2805166A1 (de)
DK (1) DK16878A (de)
ES (1) ES466793A1 (de)
FI (1) FI68619C (de)
FR (1) FR2380264A1 (de)
GB (1) GB1587373A (de)
GR (1) GR64157B (de)
HU (1) HU181868B (de)
IE (1) IE46454B1 (de)
IL (1) IL53996A (de)
IT (1) IT1092439B (de)
LU (1) LU79028A1 (de)
MX (1) MX5934E (de)
NL (1) NL7801454A (de)
NO (1) NO149813C (de)
NZ (1) NZ186411A (de)
PT (1) PT67625B (de)
SE (1) SE7801466L (de)
SU (1) SU867301A3 (de)
YU (1) YU28978A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP0008072B1 (de) * 1978-08-10 1984-02-22 Ciba-Geigy Ag Substituierte Anthranilsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Herstellung
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (da) * 1978-10-02 1980-04-03 Du Pont Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
IT1110282B (it) * 1979-02-19 1985-12-23 Acraf Tio-indazoli basici
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4438117A (en) 1980-09-03 1984-03-20 E. I. Du Pont De Nemours And Company 2-Substituted thio-4,5-diarylpyrimidines
US4355041A (en) * 1982-01-04 1982-10-19 E. I. Du Pont De Nemours And Company 4,5-Bis-(4-fluorophenyl)-1-(4-nitrobenzyl)-2-[((1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole, composition and use
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
ZA826501B (en) * 1982-09-06 1984-04-25 Du Pont Anti-hypertensive imidazole derivative
DE3504678A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
US5300519A (en) * 1988-07-06 1994-04-05 The University Of Sheffield Immunosuppressive agents
US5098707A (en) * 1989-07-31 1992-03-24 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5030644A (en) * 1989-07-31 1991-07-09 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
JPH03145473A (ja) * 1989-10-27 1991-06-20 Hisamitsu Pharmaceut Co Inc 新規なイミダゾール酢酸誘導体
GB9005966D0 (en) * 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
AU8757098A (en) * 1997-06-30 1999-02-10 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
FR2823747B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
JP6648108B2 (ja) * 2014-07-18 2020-02-14 オハイオ ユニバーシティー 生物学的シグナル伝達を改変するためのイミダゾール及びチアゾール組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1509975A (fr) * 1965-10-21 1968-01-19 Geigy Ag J R Dérivés de l'imidazole et leur préparation
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
JPS5343958B2 (de) * 1972-07-29 1978-11-24

Also Published As

Publication number Publication date
LU79028A1 (fr) 1979-05-25
IL53996A0 (en) 1978-04-30
FI68619B (fi) 1985-06-28
ES466793A1 (es) 1979-08-01
SU867301A3 (ru) 1981-09-23
IE780280L (en) 1978-08-09
AU3309778A (en) 1979-08-16
NL7801454A (nl) 1978-08-11
DK16878A (da) 1978-08-10
DE2805166A1 (de) 1978-08-10
SE7801466L (sv) 1978-08-10
AU524360B2 (en) 1982-09-16
NO149813C (no) 1984-06-27
NZ186411A (en) 1981-03-16
FI780429A7 (fi) 1978-08-10
PT67625B (en) 1979-07-17
NO780432L (no) 1978-08-10
CA1107286A (en) 1981-08-18
ATA87078A (de) 1980-12-15
CH643834A5 (de) 1984-06-29
YU28978A (en) 1983-01-21
GB1587373A (en) 1981-04-01
MX5934E (es) 1984-08-30
HU181868B (en) 1983-11-28
IE46454B1 (en) 1983-06-15
FI68619C (fi) 1985-10-10
IT1092439B (it) 1985-07-12
AT363076B (de) 1981-07-10
AR221590A1 (es) 1981-02-27
IT7820079A0 (it) 1978-02-07
US4182769A (en) 1980-01-08
GR64157B (en) 1980-02-05
FR2380264A1 (fr) 1978-09-08
PT67625A (en) 1978-03-01
NO149813B (no) 1984-03-19
JPS53130665A (en) 1978-11-14

Similar Documents

Publication Publication Date Title
IL54842A (en) 1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them
DE2862355D1 (en) Amine derivatives, their preparation and pharmaceutical compositions containing them
IL55557A0 (en) New imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL56155A (en) Substituted alkanoylanilide derivatives,their preparation and pharmaceutical compositions comprising them
IL56206A0 (en) New 1,2-benzothiazine-1,1-doxide derivatives, their preparation and pharmaceutical compositions containing them
IL53996A (en) 1-substituted-2-fluoroalkylthio-4,5-diphenyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL53043A (en) N-heterocyclylalkyl-(1-aryloxy-2-hydroxy-3-amino-propane)derivatives,their preparation and pharmaceutical compositions containing them
IL56017A (en) 5-cyano-prostacyclin derivatives,their manufacture and pharmaceutical compositions containing them
IL55765A (en) Dehydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL54948A0 (en) Novel dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL54535A0 (en) Novel -lactam derivatives, their preparation and pharmaceutical compositions containing them
IL49325A (en) 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
IL53857A0 (en) New aminoalkoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL55858A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL52857A (en) Oxo-benzopyrane derivatives,their preparation and pharmaceutical compositions containing them
IL53766A0 (en) 4-diphenylmethylene-1-hydroxybenzyl-piperidine derivatives, their preparation and pharmaceutical compositions containing them
IL55894A (en) 1-alkylenedithia (or oxathia) benzyl-4-heteroaryl-piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL55116A0 (en) Novel indole derivatives,their preparation and pharmaceutical compositions containing them
IL55857A (en) Benzodioxanylcarbonyl-piperazinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL53861A0 (en) Novel n-aralkylaniline derivatives, their preparation and pharmaceutical compositions containing them
IL53995A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL54576A0 (en) New chromene derivatives, their preparation and pharmaceutical compositions containing them
IL55095A0 (en) Novel piperidino-propanol derivatives,their preparation and pharmaceutical compositions containing them
IL55120A0 (en) New 3-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL54677A (en) N1-carboxylic acyl-n2-phenyl-2-hydroxy-1,3-diaminopropane derivatives, their preparation and pharmaceutical compositions containing them