IL48990A - 687-benzomorphan derivatives methods for their preparation and pharmaceutical composition comprising them - Google Patents

687-benzomorphan derivatives methods for their preparation and pharmaceutical composition comprising them

Info

Publication number
IL48990A
IL48990A IL48990A IL4899076A IL48990A IL 48990 A IL48990 A IL 48990A IL 48990 A IL48990 A IL 48990A IL 4899076 A IL4899076 A IL 4899076A IL 48990 A IL48990 A IL 48990A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical composition
benzomorphan derivatives
derivatives methods
methods
Prior art date
Application number
IL48990A
Other languages
English (en)
Other versions
IL48990A0 (en
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Publication of IL48990A0 publication Critical patent/IL48990A0/xx
Publication of IL48990A publication Critical patent/IL48990A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • One-Way And Automatic Clutches, And Combinations Of Different Clutches (AREA)
IL48990A 1975-02-25 1976-02-09 687-benzomorphan derivatives methods for their preparation and pharmaceutical composition comprising them IL48990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7891/75A GB1513961A (en) 1975-02-25 1975-02-25 6,7-benzomorphans method for their preparation and intermediates

Publications (2)

Publication Number Publication Date
IL48990A0 IL48990A0 (en) 1976-04-30
IL48990A true IL48990A (en) 1980-01-31

Family

ID=9841801

Family Applications (1)

Application Number Title Priority Date Filing Date
IL48990A IL48990A (en) 1975-02-25 1976-02-09 687-benzomorphan derivatives methods for their preparation and pharmaceutical composition comprising them

Country Status (20)

Country Link
US (2) US4128548A (is")
JP (2) JPS51111550A (is")
AT (1) AT360663B (is")
AU (1) AU505939B2 (is")
BE (1) BE838708A (is")
CA (1) CA1080704A (is")
CH (2) CH621115A5 (is")
DE (1) DE2606267A1 (is")
DK (1) DK76176A (is")
ES (1) ES445494A1 (is")
FR (1) FR2302092A1 (is")
GB (1) GB1513961A (is")
HU (1) HU173571B (is")
IE (1) IE43450B1 (is")
IL (1) IL48990A (is")
IT (1) IT1057250B (is")
LU (1) LU74431A1 (is")
NL (1) NL7601924A (is")
PH (1) PH12974A (is")
SE (1) SE7602235L (is")

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5381778A (en) * 1976-12-27 1978-07-19 Toshiharu Nakao Cloth loop forming apparatus in steaming apparatus
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
NL7907800A (nl) 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
US5490436A (en) * 1994-03-17 1996-02-13 At&T Corp. Liquid-chamber apparatus for active, dynamic balancing of rotating machinery
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
WO2003097608A2 (en) 2002-05-17 2003-11-27 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
TW200911796A (en) * 2007-07-26 2009-03-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
EP2220048B1 (en) * 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
CL2009001059A1 (es) 2008-05-01 2010-11-12 Boehringer Ingelheim Int Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
JP5711115B2 (ja) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
ES2432150T3 (es) 2008-07-25 2013-12-02 Boehringer Ingelheim International Gmbh Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010139673A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
JP5456555B2 (ja) * 2010-04-23 2014-04-02 株式会社マキタ 電動工具
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
MX2013004699A (es) 2010-11-02 2013-05-22 Boehringer Ingelheim Int Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138603A (en) * 1958-10-31 1964-06-23 Everette L May New benzomorphans (methanobenzazocines) and preparation thereof
US3372165A (en) * 1960-12-01 1968-03-05 Sterling Drug Inc 1, 2, 3, 4, 5, 6-hexahydro-8-hydroxy-2, 6-methano-3-benzazocine derivatives
NL156047B (nl) * 1969-06-04 1978-03-15 Acf Chemiefarma Nv Werkwijze voor de bereiding van farmaceutische preparaten met analgetische en/of morfine-antagonistische werking, gevormde preparaten, alsmede werkwijze voor de bereiding van daartoe geschikte nieuwe 6,7-benzomorfanen.
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US3969468A (en) * 1972-10-31 1976-07-13 Kyowa Hakko Kogyo Co., Ltd. 2-Amino-1,2,3,4-tetrahydronaphthalene derivatives
US4010164A (en) * 1973-03-28 1977-03-01 Boehringer Ingelheim Gmbh N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof
SU510999A3 (ru) * 1973-10-27 1976-04-15 К.Х.Берингер Зон, (Фирма) Способ получени (метоксиметил-фурилметил)6,7-бензоморфанов илиморфинанов
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
US4032529A (en) * 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates

Also Published As

Publication number Publication date
AU505939B2 (en) 1979-12-06
PH12974A (en) 1979-10-24
US4128548A (en) 1978-12-05
CH623572A5 (is") 1981-06-15
LU74431A1 (is") 1976-08-13
IE43450L (en) 1976-08-25
IE43450B1 (en) 1981-02-25
FR2302092B1 (is") 1978-11-10
DE2606267A1 (de) 1976-09-30
DK76176A (da) 1976-08-26
NL7601924A (nl) 1976-08-27
JPS51111550A (en) 1976-10-01
CH621115A5 (is") 1981-01-15
US4268673A (en) 1981-05-19
AT360663B (de) 1981-01-26
BE838708A (fr) 1976-08-19
HU173571B (hu) 1979-06-28
ES445494A1 (es) 1977-11-01
AU1085676A (en) 1977-08-11
IT1057250B (it) 1982-03-10
JPS51118767A (en) 1976-10-18
ATA137276A (de) 1980-06-15
CA1080704A (en) 1980-07-01
GB1513961A (en) 1978-06-14
SE7602235L (sv) 1976-08-26
FR2302092A1 (fr) 1976-09-24
IL48990A0 (en) 1976-04-30

Similar Documents

Publication Publication Date Title
IL48990A (en) 687-benzomorphan derivatives methods for their preparation and pharmaceutical composition comprising them
GB1518444A (en) N-phenyl-imidazolidine derivatives processes for preparing them and pharmaceutical compositions containing them
IL51074A0 (en) Isoquinolinium derivatives their preparation and pharmaceutical compositions containing them
NZ180529A (en) Erythromyc-9-yl-amine derivatives and pharmaceutical compositions
IL51124A0 (en) New quinazolone derivatives their preparation and pharmaceutical compositions containing them
ZA762263B (en) Thieno-pyridine derivatives process for their preparation and therapeutic composition contianing same
IL50815A0 (en) New aminobenzoamides their preparation and pharmaceutical compositions containing them
IL49911A0 (en) New 5-aroylpyrrole derivatives,their preparation and pharmaceutical compositions containing them
NZ179835A (en) Aminoalkynoic acids,derivatives and pharmaceutical compositions
IL48806A0 (en) New biphenyloxy derivatives,their preparation and pharmaceutical compositions containing them
IL50631A (en) 1-benzazolylalkyl-4-substituted-piperidines their preparation and pharmaceutical compositions containing them
IL50869A (en) Heterocyclylthio-ethylimidazole derivatives,their preparation and pharmaceutical compositions containing them
GB1537880A (en) 1-triarylalkyl-4-phenyl-4-piperidine-methanols and derivatives and pharmaceutical compositions containing them
IL50930A0 (en) New pyrimidine derivatives their preparation and pharmaceutical compositions containing them
ZA764305B (en) Phenoxy derivatives process for their preparation and pharmaceutical compositions containing them
IL51028A0 (en) New indazole derivatives their preparation and pharmaceutical compositions containing them
IL49629A0 (en) New derivatives of 2-phenylamino-2-imidazoline,their preparation and pharmaceutical compositions containing them
NZ180379A (en) Benzophenone derivatives and pharmaceutical composition
IL50897A0 (en) Daunorubicin derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
NZ182161A (en) Alkoxy-pyridine-carobxamide derivatives and pharmaceutical compositions
IL50335A (en) Diphenylalkylpolyamine derivatives,their preparation and pharmaceutical compositions containing them
IL50355A0 (en) New noroxymorphone derivatives their preparation and pharmaceutical compositions containing them
IL48453A0 (en) Novel quinuclidine derivatives and pharmaceutical compositions containing them
IL50156A0 (en) New homophthalimide derivatives,their preparation and pharmaceutical compositions containing them
GB1552460A (en) Diphenylacetamide derivatives processes for their preparation and pharmaceutical compositions containing them