IL46972A - Process for the dehydrohalogenation of 7-halo(or 1,7-dihalo) dihydrocodeinone dialkyl ketals and the new 7-chlorodihydrocodeinone dialkyl ketals - Google Patents
Process for the dehydrohalogenation of 7-halo(or 1,7-dihalo) dihydrocodeinone dialkyl ketals and the new 7-chlorodihydrocodeinone dialkyl ketalsInfo
- Publication number
- IL46972A IL46972A IL46972A IL4697275A IL46972A IL 46972 A IL46972 A IL 46972A IL 46972 A IL46972 A IL 46972A IL 4697275 A IL4697275 A IL 4697275A IL 46972 A IL46972 A IL 46972A
- Authority
- IL
- Israel
- Prior art keywords
- dialkyl ketals
- chlorodihydrocodeinone
- dihydrocodeinone
- dehydrohalogenation
- dihalo
- Prior art date
Links
- TUMPKQKJCGEPQY-MYGDZUKASA-N (4R,4aR,7aR,12bS)-6-chloro-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one Chemical compound ClC1C([C@H]2[C@]34C=5C(=C(C=CC=5C[C@H]([C@@H]3C1)N(C)CC4)OC)O2)=O TUMPKQKJCGEPQY-MYGDZUKASA-N 0.000 title 1
- 238000006704 dehydrohalogenation reaction Methods 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 title 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title 1
- 229960000240 hydrocodone Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB15971/74A GB1495271A (en) | 1974-04-10 | 1974-04-10 | Dehydrohalogenation of codeinone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL46972A0 IL46972A0 (en) | 1975-05-22 |
| IL46972A true IL46972A (en) | 1978-06-15 |
Family
ID=10068892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL46972A IL46972A (en) | 1974-04-10 | 1975-03-31 | Process for the dehydrohalogenation of 7-halo(or 1,7-dihalo) dihydrocodeinone dialkyl ketals and the new 7-chlorodihydrocodeinone dialkyl ketals |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4025520A (enExample) |
| JP (1) | JPS6259111B2 (enExample) |
| BE (1) | BE827568A (enExample) |
| CH (1) | CH614710A5 (enExample) |
| DE (1) | DE2514220A1 (enExample) |
| FR (1) | FR2275477A1 (enExample) |
| GB (1) | GB1495271A (enExample) |
| HU (1) | HU174028B (enExample) |
| IL (1) | IL46972A (enExample) |
| NL (1) | NL7504207A (enExample) |
| NO (1) | NO751054L (enExample) |
| YU (1) | YU39940B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613668A (en) * | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
| GB2392670A (en) * | 2002-09-03 | 2004-03-10 | Stylacats Ltd | (+)-Morphine production |
| CA2808199C (en) * | 2004-02-06 | 2015-10-27 | Euro-Celtique S.A. | Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates |
| DE602006019246D1 (de) * | 2005-06-16 | 2011-02-10 | Mallinckrodt Inc | Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE479104C (de) * | 1925-07-21 | 1929-07-09 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von Chlor- und Bromderivaten des Dihydrokodeinons |
| US2778832A (en) * | 1954-06-22 | 1957-01-22 | Merck & Co Inc | Reduction of codeinone to codeine |
-
1974
- 1974-04-10 GB GB15971/74A patent/GB1495271A/en not_active Expired
-
1975
- 1975-03-25 NO NO751054A patent/NO751054L/no unknown
- 1975-03-28 HU HU75MA2669A patent/HU174028B/hu unknown
- 1975-03-28 US US05/563,052 patent/US4025520A/en not_active Expired - Lifetime
- 1975-03-31 IL IL46972A patent/IL46972A/xx unknown
- 1975-04-01 DE DE19752514220 patent/DE2514220A1/de not_active Withdrawn
- 1975-04-04 BE BE155094A patent/BE827568A/xx unknown
- 1975-04-07 CH CH457375A patent/CH614710A5/xx not_active IP Right Cessation
- 1975-04-08 FR FR7510910A patent/FR2275477A1/fr active Granted
- 1975-04-09 YU YU907/75A patent/YU39940B/xx unknown
- 1975-04-09 NL NL7504207A patent/NL7504207A/xx not_active Application Discontinuation
- 1975-04-09 JP JP50043167A patent/JPS6259111B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU174028B (hu) | 1979-10-28 |
| AU7961375A (en) | 1976-09-30 |
| US4025520A (en) | 1977-05-24 |
| GB1495271A (en) | 1977-12-14 |
| NL7504207A (nl) | 1975-10-14 |
| IL46972A0 (en) | 1975-05-22 |
| YU90775A (en) | 1982-02-28 |
| FR2275477A1 (fr) | 1976-01-16 |
| DE2514220A1 (de) | 1975-10-30 |
| CH614710A5 (enExample) | 1979-12-14 |
| JPS50142600A (enExample) | 1975-11-17 |
| BE827568A (fr) | 1975-10-06 |
| YU39940B (en) | 1985-06-30 |
| FR2275477B1 (enExample) | 1979-04-20 |
| NO751054L (enExample) | 1975-10-13 |
| JPS6259111B2 (enExample) | 1987-12-09 |
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