IL43658A - Manufacture of benzyl-pyrimidines - Google Patents
Manufacture of benzyl-pyrimidinesInfo
- Publication number
- IL43658A IL43658A IL43658A IL4365873A IL43658A IL 43658 A IL43658 A IL 43658A IL 43658 A IL43658 A IL 43658A IL 4365873 A IL4365873 A IL 4365873A IL 43658 A IL43658 A IL 43658A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- formula
- lower alkoxy
- lower alkyl
- alkoxy
- Prior art date
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical class N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract 8
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract 6
- -1 methylenedioxy Chemical group 0.000 claims abstract 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract 3
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000002904 solvent Substances 0.000 claims abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31750072A | 1972-12-21 | 1972-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43658A0 IL43658A0 (en) | 1974-03-14 |
| IL43658A true IL43658A (en) | 1976-12-31 |
Family
ID=23233931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43658A IL43658A (en) | 1972-12-21 | 1973-11-20 | Manufacture of benzyl-pyrimidines |
Country Status (15)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115650A (en) | 1976-11-17 | 1978-09-19 | Hoffmann-La Roche Inc. | Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL122146C (enrdf_load_stackoverflow) * | 1960-09-02 | |||
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
| GB1407971A (en) * | 1971-04-16 | 1975-10-01 | Wellcome Found | 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor |
| BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
| BE795023A (fr) * | 1972-02-07 | 1973-08-06 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
-
1973
- 1973-11-15 ZA ZA738760*A patent/ZA738760B/xx unknown
- 1973-11-16 CA CA185,979A patent/CA986937A/en not_active Expired
- 1973-11-20 IL IL43658A patent/IL43658A/en unknown
- 1973-11-21 AU AU62755/73A patent/AU476694B2/en not_active Expired
- 1973-12-03 PH PH15286A patent/PH12708A/en unknown
- 1973-12-11 CH CH1731773A patent/CH592065A5/xx not_active IP Right Cessation
- 1973-12-19 FR FR7345496A patent/FR2211463B1/fr not_active Expired
- 1973-12-19 JP JP48141443A patent/JPS4988886A/ja active Pending
- 1973-12-19 DK DK691073AA patent/DK135531B/da unknown
- 1973-12-20 AT AT1070773A patent/AT339315B/de not_active IP Right Cessation
- 1973-12-20 DE DE2363533A patent/DE2363533A1/de active Pending
- 1973-12-20 GB GB5910473A patent/GB1411170A/en not_active Expired
- 1973-12-20 BE BE139068A patent/BE808870A/xx unknown
- 1973-12-20 NL NL7317484A patent/NL7317484A/xx unknown
- 1973-12-20 HU HUHO1636A patent/HU169082B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2363533A1 (de) | 1974-06-27 |
| ATA1070773A (de) | 1977-02-15 |
| JPS4988886A (enrdf_load_stackoverflow) | 1974-08-24 |
| AU476694B2 (en) | 1976-09-30 |
| PH12708A (en) | 1979-07-20 |
| CA986937A (en) | 1976-04-06 |
| DK135531B (da) | 1977-05-16 |
| BE808870A (fr) | 1974-06-20 |
| ZA738760B (en) | 1974-08-28 |
| CH592065A5 (enrdf_load_stackoverflow) | 1977-10-14 |
| FR2211463A1 (enrdf_load_stackoverflow) | 1974-07-19 |
| AT339315B (de) | 1977-10-10 |
| IL43658A0 (en) | 1974-03-14 |
| NL7317484A (enrdf_load_stackoverflow) | 1974-06-25 |
| DK135531C (enrdf_load_stackoverflow) | 1977-10-10 |
| GB1411170A (en) | 1975-10-29 |
| FR2211463B1 (enrdf_load_stackoverflow) | 1979-05-11 |
| AU6275573A (en) | 1975-05-22 |
| HU169082B (enrdf_load_stackoverflow) | 1976-09-28 |
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