GB1411170A - Process for the manufacture of benzylpyrimidines - Google Patents
Process for the manufacture of benzylpyrimidinesInfo
- Publication number
- GB1411170A GB1411170A GB5910473A GB5910473A GB1411170A GB 1411170 A GB1411170 A GB 1411170A GB 5910473 A GB5910473 A GB 5910473A GB 5910473 A GB5910473 A GB 5910473A GB 1411170 A GB1411170 A GB 1411170A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- alkyl
- formula
- benzylpyrimidines
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical class N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31750072A | 1972-12-21 | 1972-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1411170A true GB1411170A (en) | 1975-10-29 |
Family
ID=23233931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5910473A Expired GB1411170A (en) | 1972-12-21 | 1973-12-20 | Process for the manufacture of benzylpyrimidines |
Country Status (15)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115650A (en) | 1976-11-17 | 1978-09-19 | Hoffmann-La Roche Inc. | Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL122146C (enrdf_load_stackoverflow) * | 1960-09-02 | |||
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
| GB1407971A (en) * | 1971-04-16 | 1975-10-01 | Wellcome Found | 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor |
| BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
| BE795023A (fr) * | 1972-02-07 | 1973-08-06 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
-
1973
- 1973-11-15 ZA ZA738760*A patent/ZA738760B/xx unknown
- 1973-11-16 CA CA185,979A patent/CA986937A/en not_active Expired
- 1973-11-20 IL IL43658A patent/IL43658A/en unknown
- 1973-11-21 AU AU62755/73A patent/AU476694B2/en not_active Expired
- 1973-12-03 PH PH15286A patent/PH12708A/en unknown
- 1973-12-11 CH CH1731773A patent/CH592065A5/xx not_active IP Right Cessation
- 1973-12-19 FR FR7345496A patent/FR2211463B1/fr not_active Expired
- 1973-12-19 JP JP48141443A patent/JPS4988886A/ja active Pending
- 1973-12-19 DK DK691073AA patent/DK135531B/da unknown
- 1973-12-20 AT AT1070773A patent/AT339315B/de not_active IP Right Cessation
- 1973-12-20 DE DE2363533A patent/DE2363533A1/de active Pending
- 1973-12-20 GB GB5910473A patent/GB1411170A/en not_active Expired
- 1973-12-20 BE BE139068A patent/BE808870A/xx unknown
- 1973-12-20 NL NL7317484A patent/NL7317484A/xx unknown
- 1973-12-20 HU HUHO1636A patent/HU169082B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2363533A1 (de) | 1974-06-27 |
| ATA1070773A (de) | 1977-02-15 |
| JPS4988886A (enrdf_load_stackoverflow) | 1974-08-24 |
| AU476694B2 (en) | 1976-09-30 |
| PH12708A (en) | 1979-07-20 |
| CA986937A (en) | 1976-04-06 |
| DK135531B (da) | 1977-05-16 |
| BE808870A (fr) | 1974-06-20 |
| ZA738760B (en) | 1974-08-28 |
| CH592065A5 (enrdf_load_stackoverflow) | 1977-10-14 |
| IL43658A (en) | 1976-12-31 |
| FR2211463A1 (enrdf_load_stackoverflow) | 1974-07-19 |
| AT339315B (de) | 1977-10-10 |
| IL43658A0 (en) | 1974-03-14 |
| NL7317484A (enrdf_load_stackoverflow) | 1974-06-25 |
| DK135531C (enrdf_load_stackoverflow) | 1977-10-10 |
| FR2211463B1 (enrdf_load_stackoverflow) | 1979-05-11 |
| AU6275573A (en) | 1975-05-22 |
| HU169082B (enrdf_load_stackoverflow) | 1976-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |