GB1411170A - Process for the manufacture of benzylpyrimidines - Google Patents

Process for the manufacture of benzylpyrimidines

Info

Publication number
GB1411170A
GB1411170A GB5910473A GB5910473A GB1411170A GB 1411170 A GB1411170 A GB 1411170A GB 5910473 A GB5910473 A GB 5910473A GB 5910473 A GB5910473 A GB 5910473A GB 1411170 A GB1411170 A GB 1411170A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
alkyl
formula
benzylpyrimidines
dec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5910473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1411170A publication Critical patent/GB1411170A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1411170 Benzyl-pyrimidines FHOFFMANNLA ROCHE & CO AG 20 Dec 1973 [21 Dec 1972] 59104/73 Heading C2C [Also in Division A5] Benzylpyrimidines of Formula I in which R 1 =H or C 1-7 alkyl, R 2 =H or C 1-7 alkoxy, R 3 =C 1-7 alkyl or C 1-7 alkoxy and R 4 =H or C 1-7 alkoxy or R 2 and R 3 together = methylenedioxy, are prepared by reacting a compound of Formula II in which R = C 1-7 alkyl, with an alkali metal alkoxide in an aprotic dipolar solvent (e.g. dimethylformamide, dimethyl sulphoxide or hexamethylphosphoramide) and an alkanol of formula ROH, and treating the resulting mixture with guanidine. Compounds I potentiate the antibacterial of sulpha drugs. Reference has been directed by the Comptroller to Specification 1,133,766.
GB5910473A 1972-12-21 1973-12-20 Process for the manufacture of benzylpyrimidines Expired GB1411170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31750072A 1972-12-21 1972-12-21

Publications (1)

Publication Number Publication Date
GB1411170A true GB1411170A (en) 1975-10-29

Family

ID=23233931

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5910473A Expired GB1411170A (en) 1972-12-21 1973-12-20 Process for the manufacture of benzylpyrimidines

Country Status (15)

Country Link
JP (1) JPS4988886A (en)
AT (1) AT339315B (en)
AU (1) AU476694B2 (en)
BE (1) BE808870A (en)
CA (1) CA986937A (en)
CH (1) CH592065A5 (en)
DE (1) DE2363533A1 (en)
DK (1) DK135531B (en)
FR (1) FR2211463B1 (en)
GB (1) GB1411170A (en)
HU (1) HU169082B (en)
IL (1) IL43658A (en)
NL (1) NL7317484A (en)
PH (1) PH12708A (en)
ZA (1) ZA738760B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122146C (en) * 1960-09-02
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
GB1407971A (en) * 1971-04-16 1975-10-01 Wellcome Found 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
BE792096A (en) * 1971-12-01 1973-05-30 Hoffmann La Roche NEW BENZYLPYRIMIDINES
BE795023A (en) * 1972-02-07 1973-08-06 Hoffmann La Roche NEW BENZYLPYRIMIDINES

Also Published As

Publication number Publication date
DE2363533A1 (en) 1974-06-27
CH592065A5 (en) 1977-10-14
FR2211463A1 (en) 1974-07-19
AT339315B (en) 1977-10-10
BE808870A (en) 1974-06-20
HU169082B (en) 1976-09-28
ZA738760B (en) 1974-08-28
DK135531C (en) 1977-10-10
AU6275573A (en) 1975-05-22
DK135531B (en) 1977-05-16
JPS4988886A (en) 1974-08-24
CA986937A (en) 1976-04-06
FR2211463B1 (en) 1979-05-11
AU476694B2 (en) 1976-09-30
ATA1070773A (en) 1977-02-15
IL43658A (en) 1976-12-31
PH12708A (en) 1979-07-20
NL7317484A (en) 1974-06-25
IL43658A0 (en) 1974-03-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee