IL42546A - Preparation of n(diethylaminoethyl) 2-methoxy-4-amino-5-chlorobenzamide - Google Patents
Preparation of n(diethylaminoethyl) 2-methoxy-4-amino-5-chlorobenzamideInfo
- Publication number
- IL42546A IL42546A IL42546A IL4254673A IL42546A IL 42546 A IL42546 A IL 42546A IL 42546 A IL42546 A IL 42546A IL 4254673 A IL4254673 A IL 4254673A IL 42546 A IL42546 A IL 42546A
- Authority
- IL
- Israel
- Prior art keywords
- methoxy
- chlorobenzamide
- amino
- reacting
- diethylaminoethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1395132 N - [2 - (N,N - diethylamino)ethyl]- 2 - methoxy - 4 - amino - 5 - chlorobenzamide SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 13 June 1973 [22 June 1972] 28204/73 Heading C2C N - [2 - (N<SP>1</SP>,N<SP>1</SP> - diethylamino)ethyl] - 2- methoxy - 4 - amino - 5 - chlorobenzamide is prepared by reacting a 2-methoxy-4-acetamido- 5-chlorobenzoyl halide with 2-chloroethylamine and reacting the resulting N-(2-chloroethyl) - 2 - methoxy - 4 - acetamido - 5 - chlorobenzamide with diethylamine, followed by alkaline hydrolysis, and may be converted to its pharmaceutically acceptable mineral or organic acid addition salts and its quaternary ammonium salts.
[GB1395132A]
Claims (1)
1. CLAIMS A novel method preparing which has the and with pharmaceutically acceptable mineral or organic acids and its quaternary ammonium that comprises reacting a halide with to produce treating the compound with diethylamine by alkaline to produce and optionally reacting latter with an acid o a quaternizing agent to a A according to claim 1 in which the acid halide used is method according to claim 1 substantially as before described in the foregoing when prepared by a method as in any one of claims insufficientOCRQuality
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7222695A FR2281353A1 (en) | 1972-06-22 | 1972-06-22 | NEW PROCESS FOR THE PREPARATION OF N (DIETHYLAMINOETHYL) 2-METHOXY 4-AMINO 5-CHLOROBENZAMIDE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42546A0 IL42546A0 (en) | 1973-08-29 |
| IL42546A true IL42546A (en) | 1976-11-30 |
Family
ID=9100674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42546A IL42546A (en) | 1972-06-22 | 1973-06-19 | Preparation of n(diethylaminoethyl) 2-methoxy-4-amino-5-chlorobenzamide |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR780000254B1 (en) |
| AT (1) | AT350045B (en) |
| AU (1) | AU468922B2 (en) |
| BE (1) | BE801037A (en) |
| BG (1) | BG21398A3 (en) |
| CA (1) | CA992559A (en) |
| CH (1) | CH570971A5 (en) |
| CS (1) | CS168034B2 (en) |
| DD (1) | DD108283A5 (en) |
| DE (1) | DE2331262A1 (en) |
| ES (1) | ES416099A1 (en) |
| FR (1) | FR2281353A1 (en) |
| GB (1) | GB1395132A (en) |
| HU (1) | HU166935B (en) |
| IE (1) | IE37822B1 (en) |
| IL (1) | IL42546A (en) |
| LU (1) | LU67829A1 (en) |
| MC (1) | MC1008A1 (en) |
| YU (1) | YU36692B (en) |
| ZA (1) | ZA734193B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528037A1 (en) * | 1982-06-08 | 1983-12-09 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF PHENOLAMIDES |
| US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1233877B (en) * | 1961-07-25 | 1967-02-09 | Ile De France | Process for the preparation of substituted N- (tert. Aminoalkyl) -benzamides |
-
1972
- 1972-06-22 FR FR7222695A patent/FR2281353A1/en active Granted
-
1973
- 1973-06-08 MC MC1049A patent/MC1008A1/en unknown
- 1973-06-13 GB GB2820473A patent/GB1395132A/en not_active Expired
- 1973-06-18 BE BE1005165A patent/BE801037A/en not_active IP Right Cessation
- 1973-06-18 BG BG023904A patent/BG21398A3/en unknown
- 1973-06-18 HU HUSO1087A patent/HU166935B/hu unknown
- 1973-06-19 CS CS4411A patent/CS168034B2/cs unknown
- 1973-06-19 IL IL42546A patent/IL42546A/en unknown
- 1973-06-19 AT AT536973A patent/AT350045B/en not_active IP Right Cessation
- 1973-06-19 IE IE1006/73A patent/IE37822B1/en unknown
- 1973-06-19 CA CA174,389A patent/CA992559A/en not_active Expired
- 1973-06-19 DE DE2331262A patent/DE2331262A1/en active Pending
- 1973-06-20 KR KR7300972A patent/KR780000254B1/en active
- 1973-06-20 DD DD171686A patent/DD108283A5/xx unknown
- 1973-06-20 LU LU67829A patent/LU67829A1/xx unknown
- 1973-06-20 ES ES416099A patent/ES416099A1/en not_active Expired
- 1973-06-21 CH CH906473A patent/CH570971A5/xx not_active IP Right Cessation
- 1973-06-21 ZA ZA734193A patent/ZA734193B/en unknown
- 1973-06-21 AU AU57213/73A patent/AU468922B2/en not_active Expired
- 1973-06-22 YU YU1693/73A patent/YU36692B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG21398A3 (en) | 1976-05-20 |
| KR780000254B1 (en) | 1978-07-06 |
| DE2331262A1 (en) | 1974-01-17 |
| CS168034B2 (en) | 1976-05-28 |
| ZA734193B (en) | 1974-06-26 |
| AU5721373A (en) | 1975-01-09 |
| ATA536973A (en) | 1978-10-15 |
| IE37822B1 (en) | 1977-10-26 |
| YU169373A (en) | 1982-06-18 |
| MC1008A1 (en) | 1974-10-18 |
| CA992559A (en) | 1976-07-06 |
| BE801037A (en) | 1973-12-18 |
| ES416099A1 (en) | 1976-02-16 |
| IE37822L (en) | 1973-12-22 |
| CH570971A5 (en) | 1975-12-31 |
| YU36692B (en) | 1984-08-31 |
| HU166935B (en) | 1975-06-28 |
| DD108283A5 (en) | 1974-09-12 |
| AT350045B (en) | 1979-05-10 |
| FR2281353A1 (en) | 1976-03-05 |
| FR2281353B1 (en) | 1979-03-30 |
| AU468922B2 (en) | 1976-01-29 |
| GB1395132A (en) | 1975-05-21 |
| IL42546A0 (en) | 1973-08-29 |
| LU67829A1 (en) | 1974-07-10 |
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