IL42518A - History of 1-phenyl-3-) azetidin-1-yl-alkyl (-2-imidazolidinone - Google Patents
History of 1-phenyl-3-) azetidin-1-yl-alkyl (-2-imidazolidinoneInfo
- Publication number
- IL42518A IL42518A IL42518A IL4251873A IL42518A IL 42518 A IL42518 A IL 42518A IL 42518 A IL42518 A IL 42518A IL 4251873 A IL4251873 A IL 4251873A IL 42518 A IL42518 A IL 42518A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- prepared
- phenyl
- talc
- stearic acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 241000220479 Acacia Species 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 241000416162 Astragalus gummifer Species 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000007891 compressed tablet Substances 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- 239000000196 tragacanth Substances 0.000 claims 1
- 235000010487 tragacanth Nutrition 0.000 claims 1
- 229940116362 tragacanth Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 thionyl halide Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2740472 | 1972-07-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42518A0 IL42518A0 (en) | 1973-08-29 |
| IL42518A true IL42518A (en) | 1976-05-31 |
Family
ID=11221578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42518A IL42518A (en) | 1972-07-26 | 1973-06-17 | History of 1-phenyl-3-) azetidin-1-yl-alkyl (-2-imidazolidinone |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS5120514B2 (cs) |
| KR (1) | KR780000092B1 (cs) |
| AR (2) | AR197051A1 (cs) |
| AT (1) | AT324324B (cs) |
| AU (1) | AU469020B2 (cs) |
| BE (1) | BE801726A (cs) |
| CA (1) | CA1000281A (cs) |
| CH (1) | CH577996A5 (cs) |
| CS (1) | CS185625B2 (cs) |
| DD (1) | DD107279A5 (cs) |
| DE (1) | DE2337414C3 (cs) |
| DK (1) | DK135377B (cs) |
| ES (1) | ES417269A1 (cs) |
| FI (1) | FI56006C (cs) |
| FR (1) | FR2193617B1 (cs) |
| GB (1) | GB1383619A (cs) |
| HU (1) | HU165566B (cs) |
| IE (1) | IE37803B1 (cs) |
| IL (1) | IL42518A (cs) |
| LU (1) | LU68084A1 (cs) |
| NL (1) | NL175822C (cs) |
| NO (1) | NO137785C (cs) |
| PH (1) | PH10236A (cs) |
| PL (1) | PL91619B1 (cs) |
| RO (2) | RO62909A (cs) |
| SE (1) | SE403378B (cs) |
| SU (2) | SU548211A3 (cs) |
| YU (1) | YU35253B (cs) |
| ZA (1) | ZA734081B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1190721B (it) * | 1982-03-09 | 1988-02-24 | Lepetit Spa | Derivati 3-azetidiniletil-1-fenil-2-imidazolidinici ad attivita' neurolettica,procedimento per la loro preparazione e loro impiego |
| TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
-
1973
- 1973-06-13 GB GB2819773A patent/GB1383619A/en not_active Expired
- 1973-06-15 IE IE990/73A patent/IE37803B1/xx unknown
- 1973-06-15 ZA ZA734081A patent/ZA734081B/xx unknown
- 1973-06-17 IL IL42518A patent/IL42518A/en unknown
- 1973-06-19 YU YU1649/73A patent/YU35253B/xx unknown
- 1973-06-27 AU AU57398/73A patent/AU469020B2/en not_active Expired
- 1973-06-29 BE BE132966A patent/BE801726A/xx not_active IP Right Cessation
- 1973-06-29 FI FI2092/73A patent/FI56006C/fi active
- 1973-07-03 NO NO2729/73A patent/NO137785C/no unknown
- 1973-07-04 CA CA175,647A patent/CA1000281A/en not_active Expired
- 1973-07-06 CH CH989573A patent/CH577996A5/xx not_active IP Right Cessation
- 1973-07-10 JP JP48077837A patent/JPS5120514B2/ja not_active Expired
- 1973-07-13 DK DK389273AA patent/DK135377B/da unknown
- 1973-07-20 CS CS7300005238A patent/CS185625B2/cs unknown
- 1973-07-23 DE DE2337414A patent/DE2337414C3/de not_active Expired
- 1973-07-23 RO RO7300075563A patent/RO62909A/ro unknown
- 1973-07-23 RO RO7383723A patent/RO68382A/ro unknown
- 1973-07-24 PL PL1973164272A patent/PL91619B1/pl unknown
- 1973-07-24 DD DD172473A patent/DD107279A5/xx unknown
- 1973-07-24 AR AR249237A patent/AR197051A1/es active
- 1973-07-24 LU LU68084A patent/LU68084A1/xx unknown
- 1973-07-25 SU SU1943082A patent/SU548211A3/ru active
- 1973-07-25 AT AT655073A patent/AT324324B/de not_active IP Right Cessation
- 1973-07-25 SE SE7310351A patent/SE403378B/xx unknown
- 1973-07-25 HU HULE717A patent/HU165566B/hu unknown
- 1973-07-25 NL NLAANVRAGE7310325,A patent/NL175822C/xx not_active IP Right Cessation
- 1973-07-26 ES ES417269A patent/ES417269A1/es not_active Expired
- 1973-07-26 PH PH14864A patent/PH10236A/en unknown
- 1973-07-26 FR FR7327469A patent/FR2193617B1/fr not_active Expired
- 1973-07-26 KR KR7301222A patent/KR780000092B1/ko not_active Expired
-
1974
- 1974-02-12 AR AR252304A patent/AR197548A1/es active
-
1975
- 1975-02-27 SU SU2108069A patent/SU528870A3/ru active
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