IL42416A - 6-phenyl-4h-s-triazolo(4,3-alpha)(1,4)benzodiazepine and n-oxide derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
6-phenyl-4h-s-triazolo(4,3-alpha)(1,4)benzodiazepine and n-oxide derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL42416A IL42416A IL42416A IL4241673A IL42416A IL 42416 A IL42416 A IL 42416A IL 42416 A IL42416 A IL 42416A IL 4241673 A IL4241673 A IL 4241673A IL 42416 A IL42416 A IL 42416A
- Authority
- IL
- Israel
- Prior art keywords
- general formula
- phenyl
- benzodiazepine
- methyl
- formula
- Prior art date
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 16
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 claims 12
- 150000001557 benzodiazepines Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000005059 halophenyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- -1 alkyl lithium Chemical compound 0.000 claims 1
- 230000001773 anti-convulsant effect Effects 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003635 deoxygenating effect Effects 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 230000001624 sedative effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27143372A | 1972-07-13 | 1972-07-13 | |
| US35582973A | 1973-04-30 | 1973-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42416A0 IL42416A0 (en) | 1973-07-30 |
| IL42416A true IL42416A (en) | 1976-06-30 |
Family
ID=26954889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42416A IL42416A (en) | 1972-07-13 | 1973-05-31 | 6-phenyl-4h-s-triazolo(4,3-alpha)(1,4)benzodiazepine and n-oxide derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| AU (1) | AU5667373A (enrdf_load_stackoverflow) |
| DD (1) | DD107691A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2335282A1 (enrdf_load_stackoverflow) |
| ES (1) | ES416815A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2192823A1 (enrdf_load_stackoverflow) |
| GB (2) | GB1435982A (enrdf_load_stackoverflow) |
| IE (1) | IE37889B1 (enrdf_load_stackoverflow) |
| IL (1) | IL42416A (enrdf_load_stackoverflow) |
| LU (1) | LU67988A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7309566A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002042296A1 (en) * | 2000-11-21 | 2002-05-30 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting benzoheterocyclic derivatives |
-
1973
- 1973-05-31 IL IL42416A patent/IL42416A/en unknown
- 1973-06-07 AU AU56673/73A patent/AU5667373A/en not_active Expired
- 1973-07-09 NL NL7309566A patent/NL7309566A/xx unknown
- 1973-07-09 IE IE1150/73A patent/IE37889B1/xx unknown
- 1973-07-11 FR FR7325368A patent/FR2192823A1/fr not_active Withdrawn
- 1973-07-11 LU LU67988A patent/LU67988A1/xx unknown
- 1973-07-11 DE DE19732335282 patent/DE2335282A1/de active Pending
- 1973-07-12 ES ES416815A patent/ES416815A1/es not_active Expired
- 1973-07-12 GB GB1897375A patent/GB1435982A/en not_active Expired
- 1973-07-12 GB GB3328973A patent/GB1435981A/en not_active Expired
- 1973-07-13 DD DD172327A patent/DD107691A5/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5667373A (en) | 1974-12-12 |
| DD107691A5 (enrdf_load_stackoverflow) | 1974-08-12 |
| DE2335282A1 (de) | 1974-01-31 |
| LU67988A1 (enrdf_load_stackoverflow) | 1975-04-11 |
| IE37889L (en) | 1974-01-13 |
| IE37889B1 (en) | 1977-11-09 |
| GB1435981A (en) | 1976-05-19 |
| IL42416A0 (en) | 1973-07-30 |
| NL7309566A (enrdf_load_stackoverflow) | 1974-01-15 |
| GB1435982A (enrdf_load_stackoverflow) | 1976-05-19 |
| ES416815A1 (es) | 1976-05-16 |
| FR2192823A1 (enrdf_load_stackoverflow) | 1974-02-15 |
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