IL39743A - 1-isopropyl-4-(4'-fluorophenyl)-7-methyl-2(1h)-quinazolinone,processes for the production thereof and pharmaceutical compositions comprising this compound - Google Patents
1-isopropyl-4-(4'-fluorophenyl)-7-methyl-2(1h)-quinazolinone,processes for the production thereof and pharmaceutical compositions comprising this compoundInfo
- Publication number
- IL39743A IL39743A IL39743A IL3974372A IL39743A IL 39743 A IL39743 A IL 39743A IL 39743 A IL39743 A IL 39743A IL 3974372 A IL3974372 A IL 3974372A IL 39743 A IL39743 A IL 39743A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- methyl
- stated
- isopropyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 title claims 11
- 238000000034 method Methods 0.000 title claims 11
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000003863 ammonium salts Chemical class 0.000 claims abstract 4
- 239000004202 carbamide Substances 0.000 claims abstract 4
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 3
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 1
- 239000005695 Ammonium acetate Substances 0.000 claims 1
- 229940043376 ammonium acetate Drugs 0.000 claims 1
- 235000019257 ammonium acetate Nutrition 0.000 claims 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical group [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 claims 1
- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 claims 1
- NHJPVZLSLOHJDM-UHFFFAOYSA-N azane;butanedioic acid Chemical compound [NH4+].[NH4+].[O-]C(=O)CCC([O-])=O NHJPVZLSLOHJDM-UHFFFAOYSA-N 0.000 claims 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- -1 1 - isopropyl Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- ZYSAVXVGWOCMMF-UHFFFAOYSA-N bromo formate Chemical compound BrOC=O ZYSAVXVGWOCMMF-UHFFFAOYSA-N 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15646071A | 1971-06-24 | 1971-06-24 | |
| US20014171A | 1971-11-18 | 1971-11-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL39743A0 IL39743A0 (en) | 1972-08-30 |
| IL39743A true IL39743A (en) | 1976-04-30 |
Family
ID=26853204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL39743A IL39743A (en) | 1971-06-24 | 1972-06-22 | 1-isopropyl-4-(4'-fluorophenyl)-7-methyl-2(1h)-quinazolinone,processes for the production thereof and pharmaceutical compositions comprising this compound |
Country Status (9)
| Country | Link |
|---|---|
| AU (1) | AU4390572A (cs) |
| BE (1) | BE785283R (cs) |
| CH (1) | CH569722A5 (cs) |
| DE (1) | DE2230393C3 (cs) |
| FR (1) | FR2143345B2 (cs) |
| GB (1) | GB1379677A (cs) |
| HK (1) | HK23180A (cs) |
| IE (1) | IE36500B1 (cs) |
| IL (1) | IL39743A (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3012837A1 (de) * | 1979-04-10 | 1980-10-30 | Sandoz Ag | Analgetische und myotonolytische praeparate |
| EP1066039A4 (en) * | 1998-03-02 | 2003-02-26 | Cocensys Inc | SUBSTITUTED QUINAZOLINE AND THEIR ANALOGS AND USES |
-
1972
- 1972-06-20 CH CH925372A patent/CH569722A5/xx not_active IP Right Cessation
- 1972-06-21 GB GB2906372A patent/GB1379677A/en not_active Expired
- 1972-06-22 BE BE785283A patent/BE785283R/xx active
- 1972-06-22 DE DE2230393A patent/DE2230393C3/de not_active Expired
- 1972-06-22 IE IE881/72A patent/IE36500B1/xx unknown
- 1972-06-22 IL IL39743A patent/IL39743A/en unknown
- 1972-06-23 FR FR7222698A patent/FR2143345B2/fr not_active Expired
- 1972-06-26 AU AU43905/72A patent/AU4390572A/en not_active Expired
-
1980
- 1980-05-01 HK HK231/80A patent/HK23180A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4390572A (en) | 1974-01-03 |
| FR2143345B2 (cs) | 1977-03-25 |
| FR2143345A2 (cs) | 1973-02-02 |
| IE36500L (en) | 1972-12-24 |
| GB1379677A (en) | 1975-01-08 |
| HK23180A (en) | 1980-05-09 |
| DE2230393C3 (de) | 1978-12-07 |
| IL39743A0 (en) | 1972-08-30 |
| DE2230393B2 (de) | 1978-04-13 |
| CH569722A5 (cs) | 1975-11-28 |
| BE785283R (fr) | 1972-12-22 |
| IE36500B1 (en) | 1976-11-24 |
| AU4390672A (en) | 1974-01-03 |
| DE2230393A1 (de) | 1973-01-11 |
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