IL314791A - Treprostinil iloprost combination therapy - Google Patents
Treprostinil iloprost combination therapyInfo
- Publication number
- IL314791A IL314791A IL314791A IL31479124A IL314791A IL 314791 A IL314791 A IL 314791A IL 314791 A IL314791 A IL 314791A IL 31479124 A IL31479124 A IL 31479124A IL 314791 A IL314791 A IL 314791A
- Authority
- IL
- Israel
- Prior art keywords
- iloprost
- treprostinil
- pharmaceutically acceptable
- acceptable salt
- administering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263307919P | 2022-02-08 | 2022-02-08 | |
| PCT/US2023/062136 WO2023154705A1 (en) | 2022-02-08 | 2023-02-07 | Treprostinil iloprost combination therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL314791A true IL314791A (en) | 2024-10-01 |
Family
ID=85510816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL314791A IL314791A (en) | 2022-02-08 | 2023-02-07 | Treprostinil iloprost combination therapy |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230263807A1 (https=) |
| EP (1) | EP4475819A1 (https=) |
| JP (1) | JP2025506019A (https=) |
| KR (1) | KR20240141319A (https=) |
| CN (1) | CN118984697A (https=) |
| AU (1) | AU2023219692A1 (https=) |
| CA (1) | CA3243453A1 (https=) |
| IL (1) | IL314791A (https=) |
| WO (1) | WO2023154705A1 (https=) |
Family Cites Families (61)
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| US2485614A (en) | 1946-08-29 | 1949-10-25 | Chicago Bridge & Iron Co | Stabilizing and guide apparatus for lifter roofs |
| US3037116A (en) | 1957-07-26 | 1962-05-29 | Weber Georges | Apparatus for irradiating liquids |
| US3035516A (en) | 1958-08-18 | 1962-05-22 | Lee Brothers Company | Stencil device |
| US3646509A (en) | 1969-08-08 | 1972-02-29 | Texas Instruments Inc | Method for field stacking seismic data and system using write after read bulk data storage |
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4547016A (en) | 1984-08-13 | 1985-10-15 | Eeco Incorporated | Quick release mounting |
| GB8814438D0 (en) | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| IT1231076B (it) | 1989-09-28 | 1991-11-12 | Pirelli Cavi Spa | Procedimento per la realizzazione di gruppo di connessione separabile per fibre ottiche riunite a nastro e gruppo di connessione con esso realizzato. |
| GB9011588D0 (en) | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| EP1045695B1 (en) | 1997-11-14 | 2004-03-24 | United Therapeutics Corporation | Use of 9-deoxy-2', 9-alpha-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f 1? to treat peripheral vascular disease |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| CN1354622A (zh) | 1999-03-31 | 2002-06-19 | 联合治疗公司 | 前列腺素类化合物、组合物和治疗外周血管疾病和肺动脉高压的方法 |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6803386B2 (en) | 2002-01-16 | 2004-10-12 | United Therapeutics Corporation | Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer |
| US6756117B1 (en) | 2002-12-20 | 2004-06-29 | The United States Of America As Represented By The United States Department Of Energy | Photonic polymer-blend structures and method for making |
| CN101265226B (zh) | 2003-05-22 | 2013-04-24 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| CN1917866B (zh) | 2003-12-16 | 2010-12-15 | 联合治疗公司 | 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 |
| CA2549801C (en) | 2003-12-16 | 2012-10-16 | United Therapeutics Corporation | Use of treprostinil to improve kidney functions |
| ATE462427T1 (de) | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| MX2007000979A (es) * | 2004-07-26 | 2007-07-11 | Cotherix Inc | Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada. |
| US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| CN101495122B (zh) * | 2006-05-15 | 2011-10-05 | 联合治疗公司 | 使用定量吸入器给予曲前列尼 |
| CA2698721A1 (en) | 2007-09-07 | 2009-03-12 | United Therapeutics Corporation | Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same |
| KR20160048222A (ko) | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| US8350079B2 (en) | 2008-05-08 | 2013-01-08 | United Therapeutics Corporation | Treprostinil formulation |
| CN101827626B (zh) | 2008-06-13 | 2015-03-18 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| JP5649645B2 (ja) | 2009-05-07 | 2015-01-07 | ユナイテッド セラピューティクス コーポレイション | プロスタサイクリンアナログの固形製剤 |
| EP3108888B1 (en) | 2010-03-15 | 2020-02-12 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| US20130040898A1 (en) * | 2010-04-29 | 2013-02-14 | Pär Johansson | Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof |
| WO2011153363A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
| CA2710725C (en) | 2010-07-22 | 2017-08-01 | Alphora Research Inc. | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation |
| EP2681204B1 (en) | 2011-03-02 | 2016-04-27 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| US9388154B2 (en) | 2011-09-12 | 2016-07-12 | Lund Biotechnology PBC | Process for preparing synthetic prostacyclins |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| PL2674413T3 (pl) | 2012-06-15 | 2018-05-30 | Scipharm Sàrl | Sposób wytwarzania treprostynilu i jego pochodnych |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
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| CN105407883A (zh) | 2013-04-30 | 2016-03-16 | 联合治疗学有限公司 | 控释药物制剂 |
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| WO2015138423A1 (en) * | 2014-03-11 | 2015-09-17 | Insmed Incorporated | Prostacylin compositions and methods for using the same |
| WO2015174197A1 (ja) | 2014-05-14 | 2015-11-19 | 富士電機株式会社 | 半導体装置および半導体装置の製造方法 |
| WO2016038532A1 (en) | 2014-09-09 | 2016-03-17 | Mylan Laboratories Limited | Amorphous treprostinil diethanolamine |
| HU231184B1 (hu) | 2014-10-08 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Treprostinil-nátrium-monohidrát és eljárás ennek előállítására |
| ES2778274T3 (es) | 2014-10-20 | 2020-08-10 | United Therapeutics Corp | Síntesis de productos intermedios para producir derivados de prostaciclina |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
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| EP3442062A4 (en) | 2016-04-08 | 2019-12-18 | Idemitsu Kosan Co., Ltd. | BINDING AGENT FOR ELECTROCHEMICAL ELEMENT |
| US10898494B2 (en) * | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| KR20260020212A (ko) * | 2016-11-10 | 2026-02-10 | 아레나 파마슈티칼스, 인크. | 라리네팍 및 다른 제제의 조합에 의한 pah의 치료 방법 |
| CA3102967A1 (en) | 2018-06-07 | 2019-12-12 | Mannkind Corporation | Composition and method for inhalation |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| AU2021255621A1 (en) | 2020-04-17 | 2022-10-20 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| JP7608480B2 (ja) | 2020-06-09 | 2025-01-06 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルのフマリルジケトピペリジンプロドラッグ |
-
2023
- 2023-02-07 US US18/106,782 patent/US20230263807A1/en active Pending
- 2023-02-07 IL IL314791A patent/IL314791A/en unknown
- 2023-02-07 WO PCT/US2023/062136 patent/WO2023154705A1/en not_active Ceased
- 2023-02-07 KR KR1020247029669A patent/KR20240141319A/ko active Pending
- 2023-02-07 AU AU2023219692A patent/AU2023219692A1/en active Pending
- 2023-02-07 CA CA3243453A patent/CA3243453A1/en active Pending
- 2023-02-07 CN CN202380032526.5A patent/CN118984697A/zh active Pending
- 2023-02-07 JP JP2024547152A patent/JP2025506019A/ja active Pending
- 2023-02-07 EP EP23709893.4A patent/EP4475819A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023154705A1 (en) | 2023-08-17 |
| CN118984697A (zh) | 2024-11-19 |
| KR20240141319A (ko) | 2024-09-26 |
| AU2023219692A1 (en) | 2024-08-01 |
| EP4475819A1 (en) | 2024-12-18 |
| CA3243453A1 (en) | 2023-08-17 |
| US20230263807A1 (en) | 2023-08-24 |
| JP2025506019A (ja) | 2025-03-05 |
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