IL314032A - Methods to improve resolution of heterodimeric proteins from impurities using affinity chromatography - Google Patents
Methods to improve resolution of heterodimeric proteins from impurities using affinity chromatographyInfo
- Publication number
- IL314032A IL314032A IL314032A IL31403224A IL314032A IL 314032 A IL314032 A IL 314032A IL 314032 A IL314032 A IL 314032A IL 31403224 A IL31403224 A IL 31403224A IL 314032 A IL314032 A IL 314032A
- Authority
- IL
- Israel
- Prior art keywords
- impurities
- methods
- affinity chromatography
- improving resolution
- heterodimeric proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263298745P | 2022-01-12 | 2022-01-12 | |
| US202263430477P | 2022-12-06 | 2022-12-06 | |
| PCT/US2023/010594 WO2023137062A1 (en) | 2022-01-12 | 2023-01-11 | Methods for improving resolution of heterodimeric proteins from impurities using affinity chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL314032A true IL314032A (en) | 2024-09-01 |
Family
ID=85382626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL314032A IL314032A (en) | 2022-01-12 | 2023-01-11 | Methods to improve resolution of heterodimeric proteins from impurities using affinity chromatography |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230242579A1 (enExample) |
| EP (1) | EP4463463A1 (enExample) |
| JP (1) | JP2025502157A (enExample) |
| KR (1) | KR20240132357A (enExample) |
| AU (1) | AU2023207604A1 (enExample) |
| CA (1) | CA3242938A1 (enExample) |
| IL (1) | IL314032A (enExample) |
| MX (1) | MX2024008637A (enExample) |
| TW (1) | TW202337900A (enExample) |
| WO (1) | WO2023137062A1 (enExample) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI507525B (zh) | 2009-06-26 | 2015-11-11 | Regeneron Pharma | 具天然免疫球蛋白形式之易分離的雙專一性抗體 |
| EP3041593B1 (en) * | 2013-09-05 | 2025-01-29 | F. Hoffmann-La Roche AG | Method of cleaning a chromatography material for its reuse |
| GB201711481D0 (en) * | 2017-07-17 | 2017-08-30 | Ucb Biopharma Sprl | Protein purification |
| EP3956046A1 (en) * | 2019-04-17 | 2022-02-23 | Bristol-Myers Squibb Company | Methods for regenerating chromatography resins |
-
2023
- 2023-01-10 TW TW112101014A patent/TW202337900A/zh unknown
- 2023-01-11 WO PCT/US2023/010594 patent/WO2023137062A1/en not_active Ceased
- 2023-01-11 AU AU2023207604A patent/AU2023207604A1/en active Pending
- 2023-01-11 CA CA3242938A patent/CA3242938A1/en active Pending
- 2023-01-11 IL IL314032A patent/IL314032A/en unknown
- 2023-01-11 JP JP2024541632A patent/JP2025502157A/ja active Pending
- 2023-01-11 US US18/095,839 patent/US20230242579A1/en active Pending
- 2023-01-11 MX MX2024008637A patent/MX2024008637A/es unknown
- 2023-01-11 EP EP23707515.5A patent/EP4463463A1/en active Pending
- 2023-01-11 KR KR1020247026326A patent/KR20240132357A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4463463A1 (en) | 2024-11-20 |
| WO2023137062A1 (en) | 2023-07-20 |
| CA3242938A1 (en) | 2023-07-20 |
| US20230242579A1 (en) | 2023-08-03 |
| MX2024008637A (es) | 2024-08-27 |
| AU2023207604A1 (en) | 2024-07-25 |
| JP2025502157A (ja) | 2025-01-24 |
| TW202337900A (zh) | 2023-10-01 |
| KR20240132357A (ko) | 2024-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ781138A (en) | Anti-vegf protein compositions and methods for producing the same | |
| Sandra et al. | The versatility of heart-cutting and comprehensive two-dimensional liquid chromatography in monoclonal antibody clone selection | |
| Dada et al. | Comparison of SEC and CE-SDS methods for monitoring hinge fragmentation in IgG1 monoclonal antibodies | |
| Boyd et al. | HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region | |
| RU2014136223A (ru) | Аффинная хроматография с применением fc-рецепторов | |
| TW200716674A (en) | Anti-GM-CSF antibodies and uses therefor | |
| EP4537536A4 (en) | INTER-COMPONENT PREDICTION OF CHROMA SAMPLES | |
| Liu et al. | Characterization of free thiol variants of an IgG1 by reversed phase ultra high pressure liquid chromatography coupled with mass spectrometry | |
| EA202090262A1 (ru) | Очистка белка | |
| WO2023009891A3 (en) | Materials and methods of making or using il-23r binding proteins | |
| HK40118894A (en) | Methods for improving resolution of heterodimeric proteins from impurities using affinity chromatography | |
| Chen et al. | Monitoring removal of hole-hole homodimer by analytical hydrophobic interaction chromatography in purifying a bispecific antibody | |
| Ren et al. | Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody | |
| Kröner et al. | Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development | |
| Nowak et al. | Characterization of succinimide stability during trypsin digestion for LC-MS analysis | |
| MY208186A (en) | Liquid chromatography-mass spectrometry (lc-ms) methods for analyzing ampholyte lot variation | |
| Nakata et al. | Alteration of intracellular secretory acute phase response proteins expressed in human hepatocyte induced by exposure with interleukin-6 | |
| EP4296287A4 (en) | METHODS FOR TREATING SJÖGREN'S SYNDROME WITH TACI-FC FUSION PROTEIN | |
| WO2018190677A3 (en) | METHOD OF PURIFYING ANALOGUE ANTIBODIES USING CATION EXCHANGE CHROMATOGRAPHY | |
| EP4142794A4 (en) | IMPROVED PROCESS FOR AFFINITY CHROMATOGRAPHY | |
| Wang et al. | Protein A and captureselect FcXP affinity resins possess the capability of differentiating hole-hole homodimer isoforms | |
| CA3113756A1 (en) | Antibody quantification in biological samples | |
| ATE457798T1 (de) | Verwendung von aminen, aminosäuren oder aminosäureestern als modifikatoren der mobilen phase bei der chromatographie | |
| ATE395360T1 (de) | Neues verfahren zur aufreinigung von humanem wachstumshormon | |
| KR20240159621A (ko) | 폴리펩티드를 단리하는 방법 |