TW202337900A - 改良使用親和層析的異二聚蛋白質自雜質之解析的方法 - Google Patents

改良使用親和層析的異二聚蛋白質自雜質之解析的方法 Download PDF

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Publication number
TW202337900A
TW202337900A TW112101014A TW112101014A TW202337900A TW 202337900 A TW202337900 A TW 202337900A TW 112101014 A TW112101014 A TW 112101014A TW 112101014 A TW112101014 A TW 112101014A TW 202337900 A TW202337900 A TW 202337900A
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TW
Taiwan
Prior art keywords
value
cycles
series
protein
cycle
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Application number
TW112101014A
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English (en)
Chinese (zh)
Inventor
辛蒂 陳
安德魯 巴瑪賽
馬克 芝波羅斯基
克里斯托弗 賽文斯基
尚恩 丁
Original Assignee
美商再生元醫藥公司
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Application filed by 美商再生元醫藥公司 filed Critical 美商再生元醫藥公司
Publication of TW202337900A publication Critical patent/TW202337900A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
TW112101014A 2022-01-12 2023-01-10 改良使用親和層析的異二聚蛋白質自雜質之解析的方法 TW202337900A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263298745P 2022-01-12 2022-01-12
US63/298,745 2022-01-12
US202263430477P 2022-12-06 2022-12-06
US63/430,477 2022-12-06

Publications (1)

Publication Number Publication Date
TW202337900A true TW202337900A (zh) 2023-10-01

Family

ID=85382626

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112101014A TW202337900A (zh) 2022-01-12 2023-01-10 改良使用親和層析的異二聚蛋白質自雜質之解析的方法

Country Status (10)

Country Link
US (1) US20230242579A1 (enExample)
EP (1) EP4463463A1 (enExample)
JP (1) JP2025502157A (enExample)
KR (1) KR20240132357A (enExample)
AU (1) AU2023207604A1 (enExample)
CA (1) CA3242938A1 (enExample)
IL (1) IL314032A (enExample)
MX (1) MX2024008637A (enExample)
TW (1) TW202337900A (enExample)
WO (1) WO2023137062A1 (enExample)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI507525B (zh) 2009-06-26 2015-11-11 Regeneron Pharma 具天然免疫球蛋白形式之易分離的雙專一性抗體
EP3041593B1 (en) * 2013-09-05 2025-01-29 F. Hoffmann-La Roche AG Method of cleaning a chromatography material for its reuse
GB201711481D0 (en) * 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
EP3956046A1 (en) * 2019-04-17 2022-02-23 Bristol-Myers Squibb Company Methods for regenerating chromatography resins

Also Published As

Publication number Publication date
EP4463463A1 (en) 2024-11-20
WO2023137062A1 (en) 2023-07-20
CA3242938A1 (en) 2023-07-20
US20230242579A1 (en) 2023-08-03
MX2024008637A (es) 2024-08-27
AU2023207604A1 (en) 2024-07-25
JP2025502157A (ja) 2025-01-24
IL314032A (en) 2024-09-01
KR20240132357A (ko) 2024-09-03

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