IL312012A - Compositions and methods for the treatment of opioid overdose - Google Patents
Compositions and methods for the treatment of opioid overdoseInfo
- Publication number
- IL312012A IL312012A IL312012A IL31201224A IL312012A IL 312012 A IL312012 A IL 312012A IL 312012 A IL312012 A IL 312012A IL 31201224 A IL31201224 A IL 31201224A IL 312012 A IL312012 A IL 312012A
- Authority
- IL
- Israel
- Prior art keywords
- nalmefene
- opioid
- formulation
- administered
- therapeutically effective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Addiction (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662424378P | 2016-11-18 | 2016-11-18 | |
| PCT/US2017/060964 WO2018093666A1 (en) | 2016-11-18 | 2017-11-09 | Compositions and methods for the treatment of opioid overdose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL312012A true IL312012A (en) | 2024-06-01 |
Family
ID=62146061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL312012A IL312012A (en) | 2016-11-18 | 2017-11-09 | Compositions and methods for the treatment of opioid overdose |
| IL266674A IL266674B2 (en) | 2016-11-18 | 2017-11-09 | Compositions, devices and methods of using intranasal nalmefene and dodecyl maltoside for treatment of opioid overdose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL266674A IL266674B2 (en) | 2016-11-18 | 2017-11-09 | Compositions, devices and methods of using intranasal nalmefene and dodecyl maltoside for treatment of opioid overdose |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11458091B2 (enExample) |
| EP (1) | EP3541386A4 (enExample) |
| JP (2) | JP7312698B2 (enExample) |
| CN (1) | CN110139651A (enExample) |
| AU (2) | AU2017360910B2 (enExample) |
| CA (1) | CA3044221A1 (enExample) |
| IL (2) | IL312012A (enExample) |
| RU (1) | RU2769397C2 (enExample) |
| WO (1) | WO2018093666A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US11458091B2 (en) | 2016-11-18 | 2022-10-04 | Opiant Pharmaceuticals, Inc. | Compositions and methods for the treatment of opioid overdose |
| JP6941224B2 (ja) | 2018-02-06 | 2021-09-29 | イージス セラピューティクス，エルエルシー | 疾患の処置のための鼻腔内エピネフリン製剤及び方法 |
| WO2019222408A1 (en) * | 2018-05-17 | 2019-11-21 | Aegis Therapeutics Llc | Formulations and methods for the prevention of opioid overdose |
| US20210228570A1 (en) * | 2018-06-01 | 2021-07-29 | Purdue Pharma L.P. | Compositions and methods for opioid overdose rescue |
| JP7549576B2 (ja) * | 2018-11-06 | 2024-09-11 | パーデュー、ファーマ、リミテッド、パートナーシップ | オピオイドアンタゴニストを送達するための組成物及び方法 |
| US20210401827A1 (en) * | 2018-11-07 | 2021-12-30 | Opiant Pharmaceuticals, Inc. | Methods, parenteral pharmaceutical formulations, and devices for the prevention of opioid overdose |
| CN114144224B (zh) | 2019-03-26 | 2024-08-09 | 保科特纳洛克斯恩公司 | 药物合成物输送器械和方法 |
| US10653690B1 (en) * | 2019-07-09 | 2020-05-19 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US10729687B1 (en) | 2019-07-09 | 2020-08-04 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| CA3167312A1 (en) * | 2020-02-07 | 2021-08-12 | Stephen J. Lewis | Compositions and methods for attenuating opioid induced cardio and/or respiratory depression |
| JP2023525019A (ja) * | 2020-05-04 | 2023-06-14 | アンファスター・ファーマスーティカルズ・インコーポレイション | 薬剤の経鼻送達のための促進剤としての胆汁酸及びその塩の安全な使用 |
| IL297658A (en) | 2020-05-18 | 2022-12-01 | Orexo Ab | Pharmaceutical preparation for drug administration |
| CA3187753A1 (en) * | 2020-07-29 | 2022-02-03 | Lido Ventures Llc | Apparatus, system, and method for facilitating intranasal treatment of a patient |
| US20220387407A1 (en) * | 2021-02-08 | 2022-12-08 | Case Western Reserve University | Compositions and methods for attenuating opioid induced cardio and/or respiratory depression |
| US11278709B1 (en) | 2021-03-12 | 2022-03-22 | Pocket Naloxone Corp. | Drug delivery device and methods for using same |
| WO2023014906A1 (en) * | 2021-08-04 | 2023-02-09 | Opiant Pharmaceuticals, Inc. | Compositions and methods for the treatment of opioid overdose |
| GB202117016D0 (en) | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
| KR20240103005A (ko) | 2021-11-25 | 2024-07-03 | 오렉쏘 에이비 | 아드레날린을 포함하는 약학적 조성물 |
| WO2024222920A1 (zh) * | 2023-04-28 | 2024-10-31 | 成都苑东生物制药股份有限公司 | 一种用于鼻内给药的药物制剂及其制备方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4987136A (en) | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
| US4882335A (en) | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
| US4880813A (en) | 1988-07-22 | 1989-11-14 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for allergic rhinitis |
| US5069895A (en) | 1989-11-09 | 1991-12-03 | Diamond Ivan F | Methods for the treatment of alcohol intoxication and dependence |
| IL97075A0 (en) | 1990-02-14 | 1992-03-29 | Alcon Lab Inc | Topical pharmaceutical composition containing an alkyl saccharide |
| US5369095A (en) | 1990-02-14 | 1994-11-29 | Alcon Laboratories, Inc. | Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers |
| US6271240B1 (en) | 1996-05-06 | 2001-08-07 | David Lew Simon | Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals |
| JP2005508888A (ja) | 2001-08-14 | 2005-04-07 | バイオティ セラピーズ コーポレイション | アルコール依存症またはアルコール中毒を治療する方法 |
| US9114069B2 (en) | 2004-08-25 | 2015-08-25 | Aegis Therapeutics, Llc | Antibacterial compositions for drug administration |
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
| EP1789075A4 (en) | 2004-08-25 | 2009-07-01 | Uab Research Foundation | ABSORPTION ENHANCER FOR DRUG ADMINISTRATION |
| US8268791B2 (en) * | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| US20110257096A1 (en) | 2004-08-25 | 2011-10-20 | Aegis Therapeutics, Inc. | Compositions for drug administration |
| CN1305474C (zh) * | 2004-10-13 | 2007-03-21 | 北京国药龙立生物医药新技术有限公司 | 盐酸纳美芬鼻腔给药制剂 |
| US20070212307A1 (en) | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
| US20080090771A1 (en) | 2006-10-06 | 2008-04-17 | Shire Llc | Abuse-resistant hydrocodone compounds, compositions and methods of using the same |
| US20100076006A1 (en) | 2007-01-31 | 2010-03-25 | University Of Virginia Patent Foundation | Topiramate Plus Naltrexone for the Treatment of Addictive Disorders |
| IL187159A0 (en) | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
| US20110065628A1 (en) | 2007-08-27 | 2011-03-17 | University Of Virginia Patent Foundation | Medication Combinations for the Treatment of Alcoholism and Drug Addiction |
| JP5613657B2 (ja) | 2008-03-28 | 2014-10-29 | ヘイル バイオファーマ ベンチャーズ，エルエルシー | ベンゾジアゼピン組成物の投与 |
| WO2009128474A1 (ja) | 2008-04-16 | 2009-10-22 | 財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性シート製剤の製造方法 |
| JP5843873B2 (ja) | 2010-10-29 | 2016-01-13 | トロイカ ファーマスーティカルズ リミテッド | ビタミンｂ１２の鼻内用組成物 |
| EP2720699B1 (en) | 2011-06-14 | 2018-05-16 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine |
| US10485798B2 (en) | 2012-08-22 | 2019-11-26 | Aptapharma Inc. | Methylnaltrexone nasal formulations, methods of making, and use thereof |
| US20140171458A1 (en) | 2012-12-13 | 2014-06-19 | 3B Pharmaceuticals, Inc. | Intranasal naltrexone |
| DE202013105715U1 (de) | 2013-08-22 | 2014-02-19 | Sipnose Ltd. | Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers |
| US20160256472A1 (en) | 2013-10-14 | 2016-09-08 | Palmaya Pty Ltd | Compositions and methods of administering same |
| WO2015095389A1 (en) * | 2013-12-18 | 2015-06-25 | Aegis Therapeutics, Llc | Compositions for drug administration |
| WO2015095644A1 (en) | 2013-12-20 | 2015-06-25 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| US9561177B2 (en) | 2014-03-14 | 2017-02-07 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| US10085937B2 (en) | 2014-03-14 | 2018-10-02 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| DE112015001251T5 (de) * | 2014-03-14 | 2017-01-19 | Opiant Pharmaceuticals Inc. | Nasale Arzneimittelprodukte und Verfahren zu deren Verwendung |
| US20160008277A1 (en) | 2014-07-09 | 2016-01-14 | Lightlake Therapeutics Inc. | Co-packaged drug products |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| MX2018015985A (es) | 2016-06-24 | 2019-09-13 | Opiant Pharmaceuticals Inc | Composiciones, dispositivos y metodos para el tratamiento del trastorno relacionado con el consumo de alcohol. |
| US20190262263A1 (en) | 2016-11-09 | 2019-08-29 | Opiant Pharmaceuticals, Inc. | Compositions, devices and methods for the treatment of opioid-receptor-mediated conditions |
| US11458091B2 (en) | 2016-11-18 | 2022-10-04 | Opiant Pharmaceuticals, Inc. | Compositions and methods for the treatment of opioid overdose |
| CN106361700A (zh) | 2016-11-25 | 2017-02-01 | 威海恒基伟业信息科技发展有限公司 | 盐酸纳美芬鼻腔给药制剂 |
| WO2019222408A1 (en) | 2018-05-17 | 2019-11-21 | Aegis Therapeutics Llc | Formulations and methods for the prevention of opioid overdose |
| US20210401827A1 (en) | 2018-11-07 | 2021-12-30 | Opiant Pharmaceuticals, Inc. | Methods, parenteral pharmaceutical formulations, and devices for the prevention of opioid overdose |
| PH12021551465A1 (en) | 2018-12-20 | 2022-04-11 | Aegis Therapeutics Llc | Compositions, devices, and methods for the treatment of overdose and reward-based disorders |
| US20200390691A1 (en) | 2018-12-20 | 2020-12-17 | Aegis Therapeutics, Inc. | Compositions, devices, and methods for the treatment of overdose and reward-based disorders |
-
2017
- 2017-11-09 US US16/461,354 patent/US11458091B2/en active Active
- 2017-11-09 WO PCT/US2017/060964 patent/WO2018093666A1/en not_active Ceased
- 2017-11-09 RU RU2019118465A patent/RU2769397C2/ru active
- 2017-11-09 JP JP2019526565A patent/JP7312698B2/ja active Active
- 2017-11-09 CN CN201780081719.4A patent/CN110139651A/zh active Pending
- 2017-11-09 CA CA3044221A patent/CA3044221A1/en active Pending
- 2017-11-09 AU AU2017360910A patent/AU2017360910B2/en active Active
- 2017-11-09 EP EP17871739.3A patent/EP3541386A4/en active Pending
- 2017-11-09 IL IL312012A patent/IL312012A/en unknown
- 2017-11-09 IL IL266674A patent/IL266674B2/en unknown
-
2022
- 2022-08-04 US US17/881,191 patent/US20220387306A1/en not_active Abandoned
-
2023
- 2023-07-10 JP JP2023112864A patent/JP7730443B2/ja active Active
-
2024
- 2024-02-19 AU AU2024201047A patent/AU2024201047A1/en active Pending
- 2024-06-25 US US18/753,188 patent/US20250127712A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017360910B2 (en) | 2023-11-23 |
| AU2017360910A1 (en) | 2019-05-30 |
| CA3044221A1 (en) | 2018-05-24 |
| IL266674A (en) | 2019-07-31 |
| IL266674B2 (en) | 2024-09-01 |
| RU2769397C2 (ru) | 2022-03-31 |
| US20200060967A1 (en) | 2020-02-27 |
| EP3541386A4 (en) | 2020-05-27 |
| JP7730443B2 (ja) | 2025-08-28 |
| JP7312698B2 (ja) | 2023-07-21 |
| US20250127712A1 (en) | 2025-04-24 |
| IL266674B1 (en) | 2024-05-01 |
| JP2019534315A (ja) | 2019-11-28 |
| US20220387306A1 (en) | 2022-12-08 |
| US11458091B2 (en) | 2022-10-04 |
| AU2024201047A1 (en) | 2024-03-14 |
| RU2019118465A (ru) | 2020-12-18 |
| JP2023140359A (ja) | 2023-10-04 |
| RU2019118465A3 (enExample) | 2021-03-04 |
| EP3541386A1 (en) | 2019-09-25 |
| CN110139651A (zh) | 2019-08-16 |
| WO2018093666A1 (en) | 2018-05-24 |
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