RU2769397C2 - Композиции и способы лечения передозировки опиоидами - Google Patents

Композиции и способы лечения передозировки опиоидами Download PDF

Info

Publication number
RU2769397C2
RU2769397C2 RU2019118465A RU2019118465A RU2769397C2 RU 2769397 C2 RU2769397 C2 RU 2769397C2 RU 2019118465 A RU2019118465 A RU 2019118465A RU 2019118465 A RU2019118465 A RU 2019118465A RU 2769397 C2 RU2769397 C2 RU 2769397C2
Authority
RU
Russia
Prior art keywords
patient
pharmaceutical composition
nalmefene
opioid
nalmefene hydrochloride
Prior art date
Application number
RU2019118465A
Other languages
English (en)
Russian (ru)
Other versions
RU2019118465A3 (enExample
RU2019118465A (ru
Inventor
Роджер КРИСТАЛ
Эдвард Т. МАДЖО
Original Assignee
Опиант Фармасьютикалз, Инк.
ЭДЖИС ТЕРАПЬЮТИКС, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62146061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2769397(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Опиант Фармасьютикалз, Инк., ЭДЖИС ТЕРАПЬЮТИКС, ЭлЭлСи filed Critical Опиант Фармасьютикалз, Инк.
Publication of RU2019118465A publication Critical patent/RU2019118465A/ru
Publication of RU2019118465A3 publication Critical patent/RU2019118465A3/ru
Application granted granted Critical
Publication of RU2769397C2 publication Critical patent/RU2769397C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addiction (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2019118465A 2016-11-18 2017-11-09 Композиции и способы лечения передозировки опиоидами RU2769397C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424378P 2016-11-18 2016-11-18
US62/424,378 2016-11-18
PCT/US2017/060964 WO2018093666A1 (en) 2016-11-18 2017-11-09 Compositions and methods for the treatment of opioid overdose

Publications (3)

Publication Number Publication Date
RU2019118465A RU2019118465A (ru) 2020-12-18
RU2019118465A3 RU2019118465A3 (enExample) 2021-03-04
RU2769397C2 true RU2769397C2 (ru) 2022-03-31

Family

ID=62146061

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019118465A RU2769397C2 (ru) 2016-11-18 2017-11-09 Композиции и способы лечения передозировки опиоидами

Country Status (9)

Country Link
US (3) US11458091B2 (enExample)
EP (1) EP3541386A4 (enExample)
JP (2) JP7312698B2 (enExample)
CN (1) CN110139651A (enExample)
AU (2) AU2017360910B2 (enExample)
CA (1) CA3044221A1 (enExample)
IL (2) IL266674B2 (enExample)
RU (1) RU2769397C2 (enExample)
WO (1) WO2018093666A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
WO2018093666A1 (en) 2016-11-18 2018-05-24 Opiant Pharmaceuticals, Inc. Compositions and methods for the treatment of opioid overdose
WO2019157099A1 (en) 2018-02-06 2019-08-15 Aegis Therapeutics, Llc Intranasal epinephrine formulations and methods for the treatment of disease
US20210220346A1 (en) * 2018-05-17 2021-07-22 Aegis Therapeutics Llc Formulations and methods for the prevention of opioid overdose
US20210228570A1 (en) * 2018-06-01 2021-07-29 Purdue Pharma L.P. Compositions and methods for opioid overdose rescue
EP3876938A4 (en) 2018-11-06 2022-08-10 Purdue Pharma L.P. COMPOSITIONS AND METHODS OF ADMINISTRATION OF OPIOID ANTAGONISTS
EP3876937A4 (en) * 2018-11-07 2022-08-03 Opiant Pharmaceuticals, Inc. METHODS, PARENTERAL PHARMACEUTICAL FORMULATIONS AND DEVICES FOR OPIOID OVERDOSE PREVENTION
CN114144224B (zh) 2019-03-26 2024-08-09 保科特纳洛克斯恩公司 药物合成物输送器械和方法
US10729687B1 (en) 2019-07-09 2020-08-04 Orexo Ab Pharmaceutical composition for nasal delivery
US10653690B1 (en) 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
CA3167312A1 (en) * 2020-02-07 2021-08-12 Stephen J. Lewis Compositions and methods for attenuating opioid induced cardio and/or respiratory depression
CN115515621A (zh) * 2020-05-04 2022-12-23 安福星制药公司 胆汁酸及其盐作为药物的经鼻递送的增强剂的安全用途
PE20230382A1 (es) 2020-05-18 2023-03-06 Orexo Ab Nueva composicion farmaceutica para administracion de farmacos
US20220111162A1 (en) * 2020-07-29 2022-04-14 Lido Ventures Llc Apparatus, system, and method for facilitating intranasal treatment of a patient
US20220387407A1 (en) * 2021-02-08 2022-12-08 Case Western Reserve University Compositions and methods for attenuating opioid induced cardio and/or respiratory depression
US11278709B1 (en) 2021-03-12 2022-03-22 Pocket Naloxone Corp. Drug delivery device and methods for using same
IL310566A (en) * 2021-08-04 2024-03-01 Indivior Inc Preparations and methods for the treatment of opioid overdose
IL313016A (en) 2021-11-25 2024-07-01 Orexo Ab A pharmaceutical preparation that includes adrenaline
GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device
WO2024222920A1 (zh) * 2023-04-28 2024-10-31 成都苑东生物制药股份有限公司 一种用于鼻内给药的药物制剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095389A1 (en) * 2013-12-18 2015-06-25 Aegis Therapeutics, Llc Compositions for drug administration
RU2554814C2 (ru) * 2008-12-22 2015-06-27 ЭДЖИС ТЕРАПЬЮТИКС, ЭлЭлСи Композиции для введения лекарственных средств
US20150258019A1 (en) * 2014-03-14 2015-09-17 Lightlake Therapeutics, Inc. Nasal drug products and methods of their use
US20160166503A1 (en) * 2014-03-14 2016-06-16 Lightlake Therapeutics, Inc. Nasal drug products and methods of their use

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464378A (en) 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4987136A (en) 1982-03-16 1991-01-22 The Rockefeller University Method for controlling gastrointestinal dysmotility
US4882335A (en) 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
US4880813A (en) 1988-07-22 1989-11-14 Baker Cummins Pharmaceuticals, Inc. Method of treatment for allergic rhinitis
US5069895A (en) 1989-11-09 1991-12-03 Diamond Ivan F Methods for the treatment of alcohol intoxication and dependence
EP0444778A1 (en) 1990-02-14 1991-09-04 Alcon Laboratories, Inc. Use of alkyl saccharides to enhance the penetration of drugs
US5369095A (en) 1990-02-14 1994-11-29 Alcon Laboratories, Inc. Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers
US6271240B1 (en) 1996-05-06 2001-08-07 David Lew Simon Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals
RU2004107501A (ru) 2001-08-14 2005-02-20 Байотай Терапис Корпорейшн (Fi) Способ лечения алкоголизма или злоупотребления алкоголем
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US9114069B2 (en) 2004-08-25 2015-08-25 Aegis Therapeutics, Llc Antibacterial compositions for drug administration
EP2457580A1 (en) 2004-08-25 2012-05-30 The UAB Research Foundation Absorption enhancers for drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20110257096A1 (en) 2004-08-25 2011-10-20 Aegis Therapeutics, Inc. Compositions for drug administration
CN1305474C (zh) * 2004-10-13 2007-03-21 北京国药龙立生物医药新技术有限公司 盐酸纳美芬鼻腔给药制剂
US20070212307A1 (en) 2006-02-10 2007-09-13 Daniel Wermeling Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same
US20080090771A1 (en) 2006-10-06 2008-04-17 Shire Llc Abuse-resistant hydrocodone compounds, compositions and methods of using the same
CA2677205A1 (en) 2007-01-31 2008-08-07 University Of Virginia Patent Foundation Topiramate plus naltrexone for the treatment of addictive disorders
IL187159A0 (en) 2007-07-03 2009-02-11 Gur Megiddo Use of metadoxine in relief of alcohol intoxication
US20110065628A1 (en) 2007-08-27 2011-03-17 University Of Virginia Patent Foundation Medication Combinations for the Treatment of Alcoholism and Drug Addiction
EP2271347B1 (en) * 2008-03-28 2016-05-11 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
AU2009236960A1 (en) 2008-04-16 2009-10-22 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
EP2632430B1 (en) 2010-10-29 2018-06-06 Troikaa Pharmaceuticals Ltd Nasal compositions of vitamin b12
EP3415139B8 (en) * 2011-06-14 2022-05-18 Neurelis, Inc. Administration of benzodiazepine
US10485798B2 (en) 2012-08-22 2019-11-26 Aptapharma Inc. Methylnaltrexone nasal formulations, methods of making, and use thereof
US20140171458A1 (en) 2012-12-13 2014-06-19 3B Pharmaceuticals, Inc. Intranasal naltrexone
DE202013105715U1 (de) 2013-08-22 2014-02-19 Sipnose Ltd. Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers
EP3057596A4 (en) 2013-10-14 2017-03-29 Palmaya Pty Ltd Compositions and methods of administering same
US9192570B2 (en) 2013-12-20 2015-11-24 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US10085937B2 (en) 2014-03-14 2018-10-02 Adapt Pharma Limited Nasal drug products and methods of their use
US9561177B2 (en) 2014-03-14 2017-02-07 Adapt Pharma Limited Nasal drug products and methods of their use
CA2954637A1 (en) 2014-07-09 2016-01-14 Opiant Pharmaceuticals, Inc. Co-packaged drug products
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US20190209464A1 (en) * 2016-06-24 2019-07-11 Opiant Pharmaceuticals, Inc. Compositions, devices and methods for the treatment of alcohol use disorder
EP3538189A4 (en) 2016-11-09 2020-04-22 Opiant Pharmaceuticals, Inc. COMPOSITIONS, DEVICES AND METHODS FOR THE TREATMENT OF CONDITIONS MEDIATED BY AN OPIOID RECEPTOR
WO2018093666A1 (en) 2016-11-18 2018-05-24 Opiant Pharmaceuticals, Inc. Compositions and methods for the treatment of opioid overdose
CN106361700A (zh) 2016-11-25 2017-02-01 威海恒基伟业信息科技发展有限公司 盐酸纳美芬鼻腔给药制剂
US20210220346A1 (en) 2018-05-17 2021-07-22 Aegis Therapeutics Llc Formulations and methods for the prevention of opioid overdose
EP3876937A4 (en) 2018-11-07 2022-08-03 Opiant Pharmaceuticals, Inc. METHODS, PARENTERAL PHARMACEUTICAL FORMULATIONS AND DEVICES FOR OPIOID OVERDOSE PREVENTION
SG11202106531VA (en) 2018-12-20 2021-07-29 Aegis Therapeutics Llc Compositions, devices, and methods for the treatment of overdose and reward-based disorders
US20200390691A1 (en) 2018-12-20 2020-12-17 Aegis Therapeutics, Inc. Compositions, devices, and methods for the treatment of overdose and reward-based disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2554814C2 (ru) * 2008-12-22 2015-06-27 ЭДЖИС ТЕРАПЬЮТИКС, ЭлЭлСи Композиции для введения лекарственных средств
WO2015095389A1 (en) * 2013-12-18 2015-06-25 Aegis Therapeutics, Llc Compositions for drug administration
US20150258019A1 (en) * 2014-03-14 2015-09-17 Lightlake Therapeutics, Inc. Nasal drug products and methods of their use
US20160166503A1 (en) * 2014-03-14 2016-06-16 Lightlake Therapeutics, Inc. Nasal drug products and methods of their use

Also Published As

Publication number Publication date
WO2018093666A1 (en) 2018-05-24
US11458091B2 (en) 2022-10-04
AU2017360910A1 (en) 2019-05-30
EP3541386A1 (en) 2019-09-25
US20200060967A1 (en) 2020-02-27
US20250127712A1 (en) 2025-04-24
JP2019534315A (ja) 2019-11-28
JP7312698B2 (ja) 2023-07-21
RU2019118465A3 (enExample) 2021-03-04
IL266674B2 (en) 2024-09-01
JP7730443B2 (ja) 2025-08-28
JP2023140359A (ja) 2023-10-04
CA3044221A1 (en) 2018-05-24
AU2017360910B2 (en) 2023-11-23
EP3541386A4 (en) 2020-05-27
RU2019118465A (ru) 2020-12-18
CN110139651A (zh) 2019-08-16
IL266674B1 (en) 2024-05-01
IL312012A (en) 2024-06-01
AU2024201047A1 (en) 2024-03-14
IL266674A (en) 2019-07-31
US20220387306A1 (en) 2022-12-08

Similar Documents

Publication Publication Date Title
RU2769397C2 (ru) Композиции и способы лечения передозировки опиоидами
JP7492548B2 (ja) アルコール使用障害の処置のための組成物、装置、及び、方法
US20210077382A1 (en) Compositions, devices, and methods for the treatment of opioid-receptor-mediated conditions
US20240197719A1 (en) Formulations and methods for the prevention of opioid overdose
JP2024164155A (ja) 過剰摂取および報酬に基づく障害を処置するための、組成物、装置、および方法
US12290596B2 (en) Compositions and methods for the treatment of opioid overdose
US20240408004A1 (en) Compositions, devices, and methods for the treatment of overdose and reward-based disorders
US20200390691A1 (en) Compositions, devices, and methods for the treatment of overdose and reward-based disorders
US20240408003A1 (en) Compositions, devices and methods for the treatment of alcohol use disorder