IL30966A - Phenylpropiophenones and method of using them - Google Patents
Phenylpropiophenones and method of using themInfo
- Publication number
- IL30966A IL30966A IL30966A IL3096668A IL30966A IL 30966 A IL30966 A IL 30966A IL 30966 A IL30966 A IL 30966A IL 3096668 A IL3096668 A IL 3096668A IL 30966 A IL30966 A IL 30966A
- Authority
- IL
- Israel
- Prior art keywords
- phenylpropiophenone
- hydrochloride
- mice
- methylamino
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 9
- CQLXSFDDEBUZQZ-UHFFFAOYSA-N 1,2-diphenylpropan-1-one Chemical class C=1C=CC=CC=1C(C)C(=O)C1=CC=CC=C1 CQLXSFDDEBUZQZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 208000020401 Depressive disease Diseases 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 5-( 2-dimethylaminopropyl ) -10, ll-dihydro-5H-dibenz [b, f] -azepine hydrochloride Chemical compound 0.000 description 24
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 24
- 241000699670 Mus sp. Species 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 15
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 239000007787 solid Substances 0.000 description 11
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- 230000000694 effects Effects 0.000 description 10
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- 235000019359 magnesium stearate Nutrition 0.000 description 3
- KRIOVPPHQSLHCZ-UHFFFAOYSA-N propiophenone Chemical compound CCC(=O)C1=CC=CC=C1 KRIOVPPHQSLHCZ-UHFFFAOYSA-N 0.000 description 3
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- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 2
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- 231100000027 toxicology Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
- C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68381467A | 1967-11-17 | 1967-11-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL30966A0 IL30966A0 (en) | 1968-12-26 |
| IL30966A true IL30966A (en) | 1972-06-28 |
Family
ID=24745546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL30966A IL30966A (en) | 1967-11-17 | 1968-10-29 | Phenylpropiophenones and method of using them |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3495015A (fr) |
| BE (1) | BE723890A (fr) |
| ES (1) | ES360337A1 (fr) |
| FR (1) | FR7994M (fr) |
| GB (1) | GB1215966A (fr) |
| IL (1) | IL30966A (fr) |
| NL (1) | NL6816098A (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3979410A (en) * | 1974-01-21 | 1976-09-07 | Hoffmann-La Roche Inc. | Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes |
| JPS54125630A (en) * | 1978-02-22 | 1979-09-29 | Nippon Zoki Pharmaceutical Co | Novel propanone derivative*its manufacture and medical composition containing it as active component |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3203962A (en) * | 1962-10-11 | 1965-08-31 | Ciba Geigy Corp | Alpha-phenyl-beta pyrrolidino-propiophenones |
-
1967
- 1967-11-17 US US683814A patent/US3495015A/en not_active Expired - Lifetime
-
1968
- 1968-10-29 IL IL30966A patent/IL30966A/en unknown
- 1968-11-05 GB GB52349/68A patent/GB1215966A/en not_active Expired
- 1968-11-12 NL NL6816098A patent/NL6816098A/xx unknown
- 1968-11-13 FR FR173523A patent/FR7994M/fr not_active Expired
- 1968-11-14 BE BE723890D patent/BE723890A/xx unknown
- 1968-11-16 ES ES360337A patent/ES360337A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3495015A (en) | 1970-02-10 |
| NL6816098A (fr) | 1969-05-20 |
| BE723890A (fr) | 1969-05-14 |
| ES360337A1 (es) | 1970-10-16 |
| GB1215966A (en) | 1970-12-16 |
| IL30966A0 (en) | 1968-12-26 |
| FR7994M (fr) | 1970-06-08 |
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