GB1215966A - Pharmaceutical antidepressant compositions - Google Patents

Pharmaceutical antidepressant compositions

Info

Publication number
GB1215966A
GB1215966A GB52349/68A GB5234968A GB1215966A GB 1215966 A GB1215966 A GB 1215966A GB 52349/68 A GB52349/68 A GB 52349/68A GB 5234968 A GB5234968 A GB 5234968A GB 1215966 A GB1215966 A GB 1215966A
Authority
GB
United Kingdom
Prior art keywords
phenylpropiophenones
nov
amino
alkyl
desoxybenzoin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52349/68A
Inventor
Corris Mabelle Hofmann
Sidney Robert Safir
Eugene Newton Greenblatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1215966A publication Critical patent/GB1215966A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,215,966. Substituted-3-amino-2 phenylpropiophenones. AMERICAN CYANAMID CO. 5 Nov., 1968 [17 Nov., 1967], No. 52349/68. Heading C2C. [Also in Division A5] 3 - Amino - 2 - phenylpropiophenones of the general formula wherein R and R 1 are H, C 1-6 alkyl or cycloalkyl of 3 to 6 C atoms and X and Y may each be H, halogen, C 1-6 alkyl or C 1-6 alkoxy and acid addition salts thereof are prepared by reacting a suitably substituted desoxybenzoin with formaldehyde in a polar solvent in the presence of a catalytic amount of a base such as piperidine and adding the resulting methylene desoxybenzoin to a liquid amine with or without a solvent being present and optionally followed by salt formation.
GB52349/68A 1967-11-17 1968-11-05 Pharmaceutical antidepressant compositions Expired GB1215966A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68381467A 1967-11-17 1967-11-17

Publications (1)

Publication Number Publication Date
GB1215966A true GB1215966A (en) 1970-12-16

Family

ID=24745546

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52349/68A Expired GB1215966A (en) 1967-11-17 1968-11-05 Pharmaceutical antidepressant compositions

Country Status (7)

Country Link
US (1) US3495015A (en)
BE (1) BE723890A (en)
ES (1) ES360337A1 (en)
FR (1) FR7994M (en)
GB (1) GB1215966A (en)
IL (1) IL30966A (en)
NL (1) NL6816098A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004000A1 (en) * 1978-02-22 1979-09-19 Nippon Zoki Pharmaceutical Co. Ltd. New propanone derivatives, process for producing thereof and pharmaceutical compositions containing these derivatives as active ingredients

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979410A (en) * 1974-01-21 1976-09-07 Hoffmann-La Roche Inc. Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3203962A (en) * 1962-10-11 1965-08-31 Ciba Geigy Corp Alpha-phenyl-beta pyrrolidino-propiophenones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004000A1 (en) * 1978-02-22 1979-09-19 Nippon Zoki Pharmaceutical Co. Ltd. New propanone derivatives, process for producing thereof and pharmaceutical compositions containing these derivatives as active ingredients

Also Published As

Publication number Publication date
NL6816098A (en) 1969-05-20
BE723890A (en) 1969-05-14
US3495015A (en) 1970-02-10
IL30966A (en) 1972-06-28
IL30966A0 (en) 1968-12-26
ES360337A1 (en) 1970-10-16
FR7994M (en) 1970-06-08

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