IL308589A - Serpin-fused polypeptides and methods of using them - Google Patents
Serpin-fused polypeptides and methods of using themInfo
- Publication number
- IL308589A IL308589A IL308589A IL30858923A IL308589A IL 308589 A IL308589 A IL 308589A IL 308589 A IL308589 A IL 308589A IL 30858923 A IL30858923 A IL 30858923A IL 308589 A IL308589 A IL 308589A
- Authority
- IL
- Israel
- Prior art keywords
- polypeptide
- fusion protein
- aat
- seq
- amino acid
- Prior art date
Links
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Endocrinology (AREA)
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- Cardiology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| PCT/US2015/057533 WO2016069574A1 (en) | 2014-10-27 | 2015-10-27 | Serpin fusion polypeptides and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL308589A true IL308589A (en) | 2024-01-01 |
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| IL251799A IL251799B2 (en) | 2014-10-27 | 2015-10-27 | Serpin-fused polypeptides and methods of using them |
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| EP (1) | EP3212290A4 (zh) |
| JP (2) | JP6737781B2 (zh) |
| KR (2) | KR20240005109A (zh) |
| CN (2) | CN114316068A (zh) |
| AU (2) | AU2015339507B2 (zh) |
| BR (1) | BR112017008525A2 (zh) |
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| UA (1) | UA127305C2 (zh) |
| WO (1) | WO2016069574A1 (zh) |
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| CN113286816A (zh) * | 2018-10-29 | 2021-08-20 | 斯宾疗法有限责任公司 | 用于α-1-抗胰蛋白酶病症的组合物和方法 |
| WO2020097946A1 (zh) * | 2018-11-18 | 2020-05-22 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素10融合蛋白及其应用 |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| WO2022133521A1 (en) * | 2020-12-21 | 2022-06-30 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| WO2022184854A2 (en) * | 2021-03-03 | 2022-09-09 | Formycon Ag | Formulations of ace2 fc fusion proteins |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| TW202409072A (zh) | 2022-05-16 | 2024-03-01 | 美商英伊布里克斯公司 | 用於治療個體的α－１抗胰蛋白酶（ＡＡＴ）缺乏症之方法的重組絲胺酸蛋白酶抑制劑（ｓｅｒｐｉｎ）－Ｆｃ融合蛋白之有效劑量 |
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| WO2000052160A1 (en) * | 1999-03-01 | 2000-09-08 | Human Genome Sciences, Inc. | Human serpin proteins |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| EP2368900A3 (en) * | 2003-07-18 | 2012-07-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| CA2536918A1 (en) * | 2003-08-26 | 2005-03-03 | Leland Shapiro | Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| DK2325207T3 (en) * | 2004-11-12 | 2017-06-06 | Xencor Inc | Fc variants with altered binding to FcRn |
| EP2083081A1 (en) * | 2005-07-22 | 2009-07-29 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| CA2618951A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | Mcp1 fusions |
| AU2009262199B2 (en) * | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| SI2786762T1 (sl) * | 2008-12-19 | 2019-07-31 | Macrogenics, Inc. | Kovalentna diatelesa in njihove uporabe |
| NZ612379A (en) * | 2010-12-23 | 2014-10-31 | Janssen Biotech Inc | Active protease-resistant antibody fc mutants |
| EP3590965A1 (en) * | 2011-03-29 | 2020-01-08 | Roche Glycart AG | Antibody fc variants |
| US8986688B2 (en) * | 2011-06-28 | 2015-03-24 | Inhibrx, Llc | WAP domain fusion polypeptides and methods of use thereof |
| RS59368B1 (sr) * | 2011-06-28 | 2019-11-29 | Inhibrx Lp | Fuzioni polipeptidi na bazi serpina i postupci za njihovu upotrebu |
| AU2013202648B2 (en) * | 2012-01-10 | 2016-05-19 | Konkuk University | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| EP2863954A1 (en) * | 2012-06-21 | 2015-04-29 | Indiana University Research and Technology Corporation | Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function |
| WO2014001325A1 (en) * | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| SI2880170T1 (sl) * | 2012-08-02 | 2016-12-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo topnega FCR kot FC-fuzije z inertno imunoglobulinsko FC-regijo in uporabe le-tega |
| WO2014089375A1 (en) * | 2012-12-05 | 2014-06-12 | Boston Strategics Corporation | Protein expression enhancing polypeptides |
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2015
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| AU2015339507A1 (en) | 2017-05-11 |
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| IL251799A0 (en) | 2017-06-29 |
| CA2965151A1 (en) | 2016-05-06 |
| RU2017118325A3 (zh) | 2019-03-21 |
| SG11201703390SA (en) | 2017-05-30 |
| AU2021240153A1 (en) | 2021-10-28 |
| HK1244460A1 (zh) | 2018-08-10 |
| WO2016069574A1 (en) | 2016-05-06 |
| SG10201903142RA (en) | 2019-05-30 |
| MX2021012047A (es) | 2021-11-03 |
| EP3212290A1 (en) | 2017-09-06 |
| KR20240005109A (ko) | 2024-01-11 |
| CN114316068A (zh) | 2022-04-12 |
| EP3212290A4 (en) | 2019-01-23 |
| UA127305C2 (uk) | 2023-07-19 |
| KR20170091096A (ko) | 2017-08-08 |
| MX2017005467A (es) | 2017-11-30 |
| JP2020180157A (ja) | 2020-11-05 |
| RU2746550C2 (ru) | 2021-04-15 |
| JP2017537888A (ja) | 2017-12-21 |
| RU2017118325A (ru) | 2018-11-29 |
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